Cutaneous hyperpigmentation and megaloblastic anemia as manifestations of gastric syphilis

Lacerda, Priscila Neri; Campos, Luana Moraes; Ré, Mariana Righetto de; Miot, Hélio Amante

doi:10.1111/ijd.15535

Cited by 2 publications

(1 citation statement)

References 4 publications

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“…Complications such as gastric obstruction or perforation were reported infrequently. Furthermore, rare associations such as hepatomegaly mimicking liver disease [3], membranous glomerulonephritis [43], and megaloblastic anemia [44,45] were found in our literature search; finally, the HIV co-infection rate among GS cases reviewed was relatively low, as shown in the previous systematic review performed on this topic by Mylona and co-workers [3].…”

Section: Discussionmentioning

confidence: 59%

Gastric Syphilis Presenting as a Nodal Inflammatory Pseudotumor Mimicking a Neoplasm: Don’t Forget the Treponema! Case Report and Scoping Review of the Literature of the Last 65 Years

Sinagra

Macaione

Stella

et al. 2023

Gastroenterology Insights

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Despite the fact that gastric syphilis is considered rare, it is reported as a type of organic involvement that is present in a large proportion of secondary syphilis cases, even though gastritis presenting with symptoms is extremely rare. Clinical, radiological, and endoscopic findings are non-specific and frequently mimic the symptoms of gastric adenocarcinoma or lymphoma, making diagnosis difficult. Immunostaining is required for this diagnosis. We would like to emphasize the importance of being suspicious of GS when a gastric mass exhibits the histologic features of an inflammatory pseudotumor (IPT), as previously reported for nodal IPT caused by luetic infection. We described a 56-year-old man who presented to the oncology department with a 3-month history of anorexia, epigastric pain, nausea, vomiting, and weight loss, as well as an initial radiological and endoscopic suspicion of gastric adenocarcinoma, in which immune staining allowed us to diagnose GS. In addition, we conducted an updated scoping review of the scientific literature to show the clinical, laboratory, and therapeutic findings in GS patients over the last 65 years.

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Section: Discussionmentioning

confidence: 59%

Gastric Syphilis Presenting as a Nodal Inflammatory Pseudotumor Mimicking a Neoplasm: Don’t Forget the Treponema! Case Report and Scoping Review of the Literature of the Last 65 Years

Sinagra

Macaione

Stella

et al. 2023

Gastroenterology Insights

View full text Add to dashboard Cite

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Infectious Gastric Diseases Other than Helicobacter

Jo,

Shin

2023

Korean J Gastroenterol

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In addition to Helicobacter pylori, the acute bacterial causes of infectious gastritis, include phlegmonous gastritis, gastric tuberculosis, and gastric syphilis. Bacterial gastritis often improves with appropriate broad-spectrum antibiotics, emphasizing the need for prompt diagnosis and treatment based on the clinical and endoscopic findings. Among viral gastritis, cytomegalovirus gastritis, primarily occurring in immunocompromised patients, necessitates antiviral intervention, while immunocompetent individuals typically achieve amelioration by administering proton pump inhibitors. In contrast, most gastric infections caused by the Epstein-Barr virus (EBV) are asymptomatic, but an EBV infection is a cause of stomach cancer. EBV-associated gastric cancer exhibits distinct clinical, pathological, genetic, and post-genetic mutation features, making it clinically significant. The colonization of Candida albicans in the stomach is uncommon, and typical antifungal treatment is unnecessary. Candida infections in gastric ulcers can be treated with anti-ulcer treatment alone. Lastly, anisakidosis in the stomach, which occurs when consuming raw seafood, can manifest in various clinical presentations and is typically treated through endoscopic removal of the nematode. This article aims to contribute to the rapid diagnosis and treatment of rare stomach infections beyond Helicobacter pylori in real clinical situations.

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Cutaneous hyperpigmentation and megaloblastic anemia as manifestations of gastric syphilis

Cited by 2 publications

References 4 publications

Gastric Syphilis Presenting as a Nodal Inflammatory Pseudotumor Mimicking a Neoplasm: Don’t Forget the Treponema! Case Report and Scoping Review of the Literature of the Last 65 Years

Gastric Syphilis Presenting as a Nodal Inflammatory Pseudotumor Mimicking a Neoplasm: Don’t Forget the Treponema! Case Report and Scoping Review of the Literature of the Last 65 Years

Infectious Gastric Diseases Other than Helicobacter

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