1995
DOI: 10.1016/0190-9622(95)91480-3
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Cutaneous extramedullary hematopoiesis

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Cited by 30 publications
(27 citation statements)
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“…9 It is believed that hematopoiesis can continue to occur in the skin after birth. 9-12 Cutaneous EMH has been occasionally described, primarily in association with chronic idiopathic myelofibrosis, [13][14][15] but it has not been reported in the setting of MDS with myelofibrosis. Compared with MDS without myelofibrosis, MDS with myelofibrosis is characterized by the following hematologic features 3-5,16-18 : (1) marked fibrosis of the bone marrow; (2) increased numbers of small hypolobulated megakaryocytes in the bone marrow; (3) modest or absent visceral enlargement; and (4) poor prognosis as a result of high incidence of bone-marrow failure.…”
Section: Discussionmentioning
confidence: 98%
“…9 It is believed that hematopoiesis can continue to occur in the skin after birth. 9-12 Cutaneous EMH has been occasionally described, primarily in association with chronic idiopathic myelofibrosis, [13][14][15] but it has not been reported in the setting of MDS with myelofibrosis. Compared with MDS without myelofibrosis, MDS with myelofibrosis is characterized by the following hematologic features 3-5,16-18 : (1) marked fibrosis of the bone marrow; (2) increased numbers of small hypolobulated megakaryocytes in the bone marrow; (3) modest or absent visceral enlargement; and (4) poor prognosis as a result of high incidence of bone-marrow failure.…”
Section: Discussionmentioning
confidence: 98%
“…Skin involvement is an extremely rare manifestation. In our case, atypical megakaryocytes were predominant, which play an important role in the pathogenesis of myelofibrosis 1 …”
Section: Discussionmentioning
confidence: 46%
“…We have found published reports of only 28 cases. [1][2][3] Although the most common underlying condition in EMH (at all sites) is CIMF, 4 only one patient with cutaneous EMH was found in three large series of 220 patients with CIMF. 5-7 A recent review of 510 patients with EMH revealed 27 patients with non-hepatosplenic EMH, and 18 out of these 27 had underlying CIMF.…”
Section: Discussionmentioning
confidence: 99%