Cutaneous extramedullary hematopoiesis

Patel, B. M.; Su, Wei; Perniciaro, Charles; Gertz, Morie A.

doi:10.1016/0190-9622(95)91480-3

Cited by 30 publications

(27 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…9 It is believed that hematopoiesis can continue to occur in the skin after birth. 9-12 Cutaneous EMH has been occasionally described, primarily in association with chronic idiopathic myelofibrosis, [13][14][15] but it has not been reported in the setting of MDS with myelofibrosis. Compared with MDS without myelofibrosis, MDS with myelofibrosis is characterized by the following hematologic features 3-5,16-18 : (1) marked fibrosis of the bone marrow; (2) increased numbers of small hypolobulated megakaryocytes in the bone marrow; (3) modest or absent visceral enlargement; and (4) poor prognosis as a result of high incidence of bone-marrow failure.…”

Section: Discussionmentioning

confidence: 98%

Transforming growth factor–β overexpression in cutaneous extramedullary hematopoiesis of a patient with myelodysplastic syndrome associated with myelofibrosis

Kawakami

Kimura

Kato

et al. 2008

Journal of the American Academy of Dermatology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 98%

Transforming growth factor–β overexpression in cutaneous extramedullary hematopoiesis of a patient with myelodysplastic syndrome associated with myelofibrosis

Kawakami

Kimura

Kato

et al. 2008

Journal of the American Academy of Dermatology

View full text Add to dashboard Cite

“…Skin involvement is an extremely rare manifestation. In our case, atypical megakaryocytes were predominant, which play an important role in the pathogenesis of myelofibrosis 1 …”

Section: Discussionmentioning

confidence: 46%

Cutaneous extramedullary hematopoiesis in idiopathic myelofibrosis

Rogalski¹,

Paasch²,

Friedrich³

et al. 2002

Int J Dermatology

View full text Add to dashboard Cite

A 67‐year‐old German woman presented with a 2‐month history of indolent erythematous macules and livid papulonodules of 0.5–1.5 cm in diameter scattered on her abdomen (Fig. 1). On physical examination, the patient was alert, the liver was palpable 3 cm below the right costal margin, and the spleen was enlarged 3 cm below the left costal margin. There was no lymphadenopathy. 1 Clinical lesions with extramedullary hematopoiesis on the abdomen Laboratory findings disclosed the following abnormalities: hemoglobin, 10.6 g/dL; hematocrit, 32.4%; white blood cell count, 4.600/mm3 myelocytes, with 15.2% lymphocytes, 74.1% neutrophils, 6.7% monocytes, and 3.6% eosinophils. Repeated bone marrow biopsy specimens showed severe myelofibrosis and osteosclerosis. Histologic examination of an incisional skin biopsy specimen revealed a mixed dermal infiltrate containing numerous histiocytic and myelocytic cells that resembled atypical megakaryocytes. Cells of the erythroid series were absent. The giant cells were labeled with CD61, thereby supporting the megakaryocytic lineage. The naphthol As‐D chloracetate reaction was positive on myelocytic cells of the infiltrate indicating granulocytopoiesis (Fig. 2). 2 Mixed dermal infiltrate composed of histiocytic, myelocytic, and multinuclear cells. Multinuclear cells were labeled with CD61 (upper right inset) and were negative for naphthol As‐D chloracetate reaction, which detected myelocytic cells (lower left inset) The patient had received electron‐beam irradiation 8 months previously, and had been treated with hydroxyurea (Litalir®, 500 mg/day) for 8 months before the manifestation of myelofibrosis on the skin. Two months after her first visit to our out‐patient clinic, the eruptions expanded, and electron‐beam irradiation was considered, but not performed, because of the progress of the disease. The patient's course was complicated by severe bone pain, the development of anemia (2.6 g/dL), a blast crisis with 80% undifferentiated, myelocytic blasts, and thrombocytopenia (26 × 109/L). Symptomatic treatment, such as several blood transfusions and analgesic agents, did not stabilize the situation. During this stage of the illness, the skin alterations remained unchanged. Sixteen months after the first diagnosis of myelofibrosis, the patient died due to conversion into chronic myelogenous leukemia, as shown by repetition of the bone marrow aspiration and the peripheral blood count.

show abstract

“…We have found published reports of only 28 cases. [1][2][3] Although the most common underlying condition in EMH (at all sites) is CIMF, 4 only one patient with cutaneous EMH was found in three large series of 220 patients with CIMF. 5-7 A recent review of 510 patients with EMH revealed 27 patients with non-hepatosplenic EMH, and 18 out of these 27 had underlying CIMF.…”

Section: Discussionmentioning

confidence: 99%