2002
DOI: 10.1046/j.1365-4362.2002.01635.x
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Cutaneous extramedullary hematopoiesis in idiopathic myelofibrosis

Abstract: A 67‐year‐old German woman presented with a 2‐month history of indolent erythematous macules and livid papulonodules of 0.5–1.5 cm in diameter scattered on her abdomen (Fig. 1). On physical examination, the patient was alert, the liver was palpable 3 cm below the right costal margin, and the spleen was enlarged 3 cm below the left costal margin. There was no lymphadenopathy. 1 Clinical lesions with extramedullary hematopoiesis on the abdomen Laboratory findings disclosed the following abnormalities: hemoglo… Show more

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Cited by 14 publications
(9 citation statements)
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“…By 2005, there had been 29 cases (eight females and 21 males) of CEH reported worldwide (Table 1). Eighteen cases had been reported by 1990 2–18 and 10 new cases were reported in the proceeding 15 years 19–25 . The average age of the patient was 60 years old.…”
Section: Discussionmentioning
confidence: 99%
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“…By 2005, there had been 29 cases (eight females and 21 males) of CEH reported worldwide (Table 1). Eighteen cases had been reported by 1990 2–18 and 10 new cases were reported in the proceeding 15 years 19–25 . The average age of the patient was 60 years old.…”
Section: Discussionmentioning
confidence: 99%
“…Eighteen cases had been reported by 1990 2-18 and 10 new cases were reported in the proceeding 15 years. [19][20][21][22][23][24][25] The average age of the patient was 60 years old. The youngest patient was a 45-year-old Japanese man 11 and the oldest was an 84-year-old man.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…There seems to be no association between timing of skin manifestations and time to disease progression in the reported cases. Yet, there are reports of patients with blastic transformation shortly after development of skin manifestations, which may indicate that skin involvement may serve as a sign of disease acceleration or development of blastic crisis [13,14]. In almost half of the cases, splenectomy preceded the occurrence of skin lesions but whether splenectomy has an effect on the development or progression of EMH is not clear.…”
Section: Discussionmentioning
confidence: 99%
“…Literature documentation of CEMH comprises a total of about 30 cases and appears to be most frequently associated with myelofi brosis or myeloproliferative disorders (Patel et al 1995 ;Revenga et al 2000 ;Fernandez Acenero et al 2003 ). Increased levels of transforming growth factor-beta appear to be associated with CEMH in patients with idiopathic myelofi brosis ( Collie et al 2013 ;Corella et al 2008 ;Haniffa et al 2006 ;Kawakami et al 2008 ;Kwon et al 1999 ;Lane et al 2002 ;Miyata et al 2008 ;Mizoguchi et al 1990 ;Pagerols et al 1998 ;Rodriguez et al 1991 ;Rogalski et al 2002 ;Ruberto et al 1995 ).…”
Section: Pyoderma Gangrenosum Associated With G-csfmentioning
confidence: 99%