Cutaneous collagenous vasculopathy successfully treated with pulsed dye laser

Echeverría, Begoña; Sanmartín, O.; Botella‐Estrada, Rafael; Vitiello, Magalys

doi:10.1111/j.1365-4632.2011.05237.x

Cited by 34 publications

(40 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The characteristic finding is dilation and marked thickening of the walls of superficial dermal blood vessels, due to deposition of eosinophilic hyaline material around the endothelial basal lamina 9. This material stains with PAS, is diastase resistant,9 and is also highlighted with iron colloidal stain7 and by immunohistochemistry for type IV collagen, fibronectin and laminin antibodies 1 6. It stains blue with Masson trichrome and often contains mucinous material 8.…”

Section: Discussionmentioning

confidence: 99%

“…There is no cure for this chronic and progressive condition,7 and in most reported cases, treatment was not performed or this was not specified 8. Laser therapy with 585 nm pulsed dye laser was reported in one patient, with important aesthetical improvement 7…”

Section: Discussionmentioning

confidence: 99%

“…Since the initial report, only 26 cases have been reported which, together with our case, gives a total of 28 patients 2–5. CCV is characterised by progressive development of generalised cutaneous telangiectases with unique but subtle histological features, consisting of dilated blood vessels of the superficial dermal plexus with marked wall thickening due to collagen deposition 6 7. Because it is clinically indistinguishable from generalised essential telangiectasia (GET), differing in its histology, it is possible that some cases clinically suspected to be GET may actually represent CCV 8.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cutaneous collagenous vasculopathy: a rare cause of generalised cutaneous telangiectasia

et al. 2015

View full text Add to dashboard Cite

Cutaneous collagenous vasculopathy is a rare cutaneous microangiopathy of unknown aetiology with only 27 cases reported to date. It is characterised clinically by generalised cutaneous telangiectasias and microscopically by dilation and marked thickening of the walls of superficial dermal blood vessels. Differential diagnosis should be performed with other causes of disseminated telangiectasias, including generalised essential telangiectasia, from which it is clinically indistinguishable. We report a new case of cutaneous collagenous vasculopathy in a 61-year-old woman presenting with a 5-year history of asymptomatic telangiectasias distributed symmetrically on her upper and lower limbs and highlight the importance of clinicopathological correlation for the diagnosis of this disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cutaneous collagenous vasculopathy: a rare cause of generalised cutaneous telangiectasia

et al. 2015

View full text Add to dashboard Cite

show abstract

“…When treating vascular lesions, the primary target is oxyhemoglobin [13]. Two cases of CCV have been treated by a pulsed dye laser [14]. We opted for a combination of Multiplex PDL/YAG laser on thicker, purple lesions, together with an OPL on the flatter, redder ones.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Collagenous Vasculopathy: A Rare Form of Microangiopathy Successfully Treated with a Combination of Multiplex Laser and Optimized Pulsed Light with a Review of the Literature

et al. 2015

View full text Add to dashboard Cite

Cutaneous collagenous vasculopathy (CCV) is a rare idiopathic microangiopathy of the cutaneous vasculature characterized histologically by the presence of dilated small blood vessels with flat endothelial cells and thickened walls containing hyaline material in the upper dermis. We report an elderly patient presenting with an extensive form of CCV involving the trunk, upper and lower limbs. She was treated with Multiplex PDL 595-nm/Nd:YAG 1,064-nm laser and optimized pulsed light. This approach, which has never been reported for CCV so far, resulted in a striking and almost complete clearance of the widespread lesions. We here review our knowledge about CCV and therapeutic options available with a survey of the literature.

show abstract

“…1 This entity is very rare with only 18 cases reported so far in the literature, [1][2][3][4][5][6][7][8][9][10][11] although it is likely to be underrecognized. 1 This entity is very rare with only 18 cases reported so far in the literature, [1][2][3][4][5][6][7][8][9][10][11] although it is likely to be underrecognized.…”

Section: Introductionmentioning

confidence: 99%

Cutaneous Collagenous Vasculopathy

Salama¹

2015

The American Journal of Dermatopathology

View full text Add to dashboard Cite

Cutaneous collagenous vasculopathy (CCV) is a rare distinct idiopathic microangiopathy of the superficial cutaneous vasculature. Seven new cases are reported (6 females and 1 male) ranging in age from 42 to 85 years, with some showing unusual clinical and histopathological findings. All presented with macular telangiectases starting on the lower extremities and spreading progressively in 5 cases and were suspected to have generalized essential telangiectasia. Two cases had a history of over 20 years. One case had lesions in the abdominal striae, and 1 was markedly ecchymotic. All skin biopsies showed the characteristic features of CCV with dilatation and marked thickening of the walls of superficial dermal blood vessels displaying reduplication of the basement membrane on periodic acid-Schiff-diastase stain and deposition of hyaline collagenous material immunostaining as collagen type IV, and showing decreased or absent actin staining. However, the changes were subtle and only seen focally in some biopsies. Few lymphoid cells were present around occasional vessels. Electron microscopy showed increased basement membrane lamellae with marked deposition of normal and some abnormal collagen (Luse-like bodies) and focal endothelial damage, suggesting reparative perivascular fibrosis resulting from repeated endothelial injury. These cases (and all 18 previously reported ones) are of a wide age range and no gender predilection. This disorder is underdiagnosed, and it is likely that some cases clinically suspected to be generalized essential telangiectasia may actually represent CCV. Better recognition by dermatologists may lead to more biopsies from patients with generalized telangiectasia and a further understanding of the pathogenesis of CCV and its relationship to other cutaneous vascular disorders.

show abstract

Cutaneous collagenous vasculopathy successfully treated with pulsed dye laser

Cited by 34 publications

References 10 publications

Cutaneous collagenous vasculopathy: a rare cause of generalised cutaneous telangiectasia

Cutaneous collagenous vasculopathy: a rare cause of generalised cutaneous telangiectasia

Cutaneous Collagenous Vasculopathy: A Rare Form of Microangiopathy Successfully Treated with a Combination of Multiplex Laser and Optimized Pulsed Light with a Review of the Literature

Cutaneous Collagenous Vasculopathy

Contact Info

Product

Resources

About