Cutaneous collagenous vasculopathy: papular form

Conde-Ferreirós, Alberto; Roncero-Riesco, Mónica; Cañueto, Javier; Román-Curto, Concépción; Santos‐Briz, Ángel

doi:10.5070/d3258045128

Cited by 5 publications

(6 citation statements)

References 4 publications

(7 reference statements)

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“…However, her rash had distinct papules, a finding only described in 2 other reports. 23,24 In summary, we conducted a comprehensive literature review of all previously documented CCV cases in the literature and provided a brief summary of the data, finding novel associations between CCV and visceral malignancies as well as between CCV and hypothyroidism. We also presented 2 new cases of CCV, contributing to the body of literature reporting on this rare disease.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Collagenous Vasculopathy: A Short Case Series and Literature Review

Kodali,

Agni,

Marka

et al. 2024

The American Journal of Dermatopathology

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Cutaneous collagenous vasculopathy (CCV) is a rare and idiopathic microangiopathy of superficial dermal blood vessels. There have been 75 cases described in the literature to date, not including the current report; however, given its clinical similarity to other primary telangiectasias, it is likely to be underreported and underdiagnosed. Here, we describe the clinical and histological features of 2 patients we newly diagnosed with CCV. Both generally fit the profile of prior cases and confirm previously described associations—they both are older White women, have rashes on their lower extremities, and have conditions and medications that are common among other reported cases. However, both are also somewhat atypical, as Patient 1 had symptomatic CCV and Patient 2 had a papular rash. As such, both cases broaden the spectrum of our current understanding of CCV. We also provide a comprehensive review of all published reports of CCV to date and uncover 2 previously unreported associations: one with visceral malignancy, and the other with hypothyroidism. Whether these association are coincidental is worth investigating in future studies.

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Section: Discussionmentioning

confidence: 99%

Cutaneous Collagenous Vasculopathy: A Short Case Series and Literature Review

Kodali,

Agni,

Marka

et al. 2024

The American Journal of Dermatopathology

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“…It has been suggested that endothelial cell injury, regardless of the mechanism, leading to endothelial cell denudement is a stimulus to microvascular basement membrane zone thickening 7 . The multiple laminations of the reduplicated basement membrane zones can be highlighted by Type IV collagen and PAS stains 7–11 …”

Section: Discussionmentioning

confidence: 99%

“…7 The multiple laminations of the reduplicated basement membrane zones can be highlighted by Type IV collagen and PAS stains. [7][8][9][10][11] Lipoid proteinosis exhibits a similar pattern of thickened vessel walls; however, its basis is not one of basement membrane zone reduplication as a sequela of antecedent endothelial cell injury.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous collagenous vasculopathy: A report of three cases

et al. 2022

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Cutaneous collagenous vasculopathy is a rare pauci‐inflammatory, superficial, cutaneous vasculopathy characterized by progressive fine‐branching telangiectasias clinically, while light microscopically one observes dilated venules and capillaries within the superficial dermis exhibiting excessive Type IV collagen within the vessel wall. We present three cases of collagenous vasculopathy. Two cases were associated with certain autoimmune stigmata, including a positive serologic anti‐endothelial cell antibody assay and positive lupus anticoagulant in one, while the third case had positive anti‐ribonucleoprotein (RNP) antibodies. The latter case was associated with chronic hydroxyurea therapy for an underlying myeloproliferative disorder. We explore the role of immune‐ and non‐immune‐based endothelial cell injury in the pathogenesis of collagenous vasculopathy.

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“…Annular variant and papular variant with non-blanchable minute lesions were reported. 5,6 Facial involvement is very rare. 7,8 A case of hypothermic CCV with initial breast involvement and with subsequent spread to the trunk and lower extremities in a 58-year-old woman was described.…”

Section: Discussionmentioning

confidence: 99%

“…Annular variant and papular variant with non‐blanchable minute lesions were reported 5,6 . Facial involvement is very rare 7,8 .…”

Section: Discussionmentioning

confidence: 99%

A case of cutaneous collagenous vasculopathy associated with multiple myeloma and with a pathogenic variant of the glucocerebrosidase gene

et al. 2022

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Cutaneous collagenous vasculopathy (CCV) is an extremely rare acquired microangiopathy of unknown etiology. The authors describe a case of a 68‐year‐old man, a carrier of a heterozygous pathogenic variant of the glucocerebrosidase (GBA) gene, who was diagnosed with CCV, revealing uncommon fibrinogen positivity in direct immunofluorescence. The patient was subsequently diagnosed with multiple myeloma. Treatment of the myeloma with combined chemotherapy including bortezomib, followed by autologous stem cell transplantation, led to significant reduction of cutaneous lesions. To the best of the authors' knowledge, this is the first published case of CCV in a carrier of a pathogenic variant of the GBA gene, associated with multiple myeloma and with significant regression of CCV after myeloma treatment. Direct immunofluorescence examination revealed an unusual fibrinogen deposition. Hypothetical causative role of bortezomib treatment was proposed regarding significant regression of CCV.

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Cutaneous collagenous vasculopathy: papular form

Cited by 5 publications

References 4 publications

Cutaneous Collagenous Vasculopathy: A Short Case Series and Literature Review

Cutaneous Collagenous Vasculopathy: A Short Case Series and Literature Review

Cutaneous collagenous vasculopathy: A report of three cases

A case of cutaneous collagenous vasculopathy associated with multiple myeloma and with a pathogenic variant of the glucocerebrosidase gene

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