Cutaneous candidiasis caused by Candida albicans in a young non-immunosuppressed patient: an unusual presentation

Abstract

Candidiasis is a fungal infection caused by yeasts that belong to the genus Candida. There are over 20 species of Candida yeasts that can cause infection in humans, the most common of which is Candida albicans. Candida yeasts normally reside in the intestinal tract and can be found on mucous membranes and skin without causing infection. However, under immunocompromised conditions, Candida can cause significant infections in susceptible patients. Herein, we report a peculiar presentation of a C. albicans cutaneous infection in an immunocompetent young subject. This case widens our knowledge on the C. albicans infections both in terms of host susceptibility and cutaneous manifestations.

Antifungal susceptibility pattern of Candida isolated from cutaneous candidiasis patients in eastern Guangdong region: A retrospective study of the past 10 years

“…More than 200 Candida species have been identified, of which over 15 are known for human pathogenicity, among which the C. albicans are highly reported (Palese et al, 2018). Similarly, in our study, 95.68% of cutaneous candidiasis was caused by C. albicans.…”

“…The high infection rate of C. albicans is due to its ability to grow in different morphological forms like true hyphae, pseudo-hyphae, and unicellular budding yeast, which enhance its virulence and invading host cell activity (Nam et al, 2022). Moreover, underlying diseases, immunosuppressive states, antibiotic therapy, and skin environment variation are the factors due to which the commensal C. albicans switched into a true pathogen (Palese et al, 2018). In the present study, the C. glabrata was detected in 18 cases, the highest among non-C. albicans species.…”

Radiological Significance of Symmetric Central Tegmental Tract Hyperintensity in Pediatric Patients

“…The patient with autoimmune hemolytic anemia (AIHA) also had widespread cutaneous candidiasis. While cutaneous candidiasis is a different entity than systemic candidiasis (16), widespread manifestations could be related to immunologic disorders (17). Therefore, in this patient it is still possible that CTTH could be related to unknown factors at that time, rather than AIHA.…”

Development of a Topical Amphotericin B and Bursera graveolens Essential Oil-Loaded Gel for the Treatment of Dermal Candidiasis

“…[2,3]. This type of mycosis mainly affects intertriginous areas and produces dryness, erythema, edema, erosions and pustules [4]. Topical treatments for cutaneous candidiasis include the application of azoles and polyenes such as clotrimazole, miconazole, fluconazole, itraconazole and nystatin [5][6][7].…”