Cutaneous Basosquamous Carcinoma of the Head and Neck: A Comparative Analysis

Schuller, David E.; Berg, John W.; Sherman, Gary M.; Krause, Charles J.

doi:10.1177/019459987908700405

Cited by 70 publications

(58 citation statements)

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“…1912] regarded this tumor as an intermediate form with basal cell and squamous cell car cinoma at each end of the spectrum. This was supported by Borel [1973] and Schuller et al [1979], In the opinion of Montgomery [1928], metatypical carcinoma is a fully dis tinct neoplasm with a morphology and be havior differing from that of basal cell or squamous cell carcinoma. However, Len nox and Wells [1951] as well as Nodi [1954] believe that metatypical carcinoma is simply a form ofbasal cell carcinoma.…”

Section: Discussionmentioning

confidence: 82%

Metatypical Carcinoma of the Lower Eyelid

Konrad

Wolburg

1983

Ophthalmologica

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Section: Discussionmentioning

confidence: 82%

Metatypical Carcinoma of the Lower Eyelid

Konrad

Wolburg

1983

Ophthalmologica

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“…Na revisão da literatura, apesar da raridade, algumas séries demonstraram modelos histológicos compatíveis com as teorias propostas à histogênese do carcinoma basoescamoso. Borel 6 relatou 35 casos dentre 1706 tumores malignos de pele não melanomas e Schüller et al 12 , demonstraram 71 relatos em 2603 também tumores malignos de pele não melanomas.…”

Section: Discussão Discussão Discussão Discussão Discussãounclassified

“…A incidência de metastatização do carcinoma basocelular é extremamente rara, atingindo ín-dices de 0,002% em grandes centros terciários 16 . Os índi-ces de metastatização regional dos carcinomas epidermóide, basocelular e do basoescamoso variam de 4% a 7,9%, 0,09% a 0,4% e 6,1% a 8,6%, respectivamente 6,12 . Podemos observar que as taxas de metástases foram baixas nos dois estudos.…”

Section: Discussão Discussão Discussão Discussão Discussãounclassified

“…Em razão da maior recidiva local, o tratamento ideal é a cirurgia com margens amplas de segurança. Todavia, os maiores índices de recidiva local foram observados nas cirurgias com ressecções e margens amplas 2,6,12 . Algumas séries demonstraram taxas de controle locais superior com a cirurgia de Mohs versus a ressecção cirúrgica tradicional, com 4% a 5% de recidiva local em cinco anos, especialmente nos casos de segunda recidiva 12,22 .…”

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“…Todavia, os maiores índices de recidiva local foram observados nas cirurgias com ressecções e margens amplas 2,6,12 . Algumas séries demonstraram taxas de controle locais superior com a cirurgia de Mohs versus a ressecção cirúrgica tradicional, com 4% a 5% de recidiva local em cinco anos, especialmente nos casos de segunda recidiva 12,22 . A radioterapia frequentemente tem indicação no pós-operatótio e nos casos de infiltração perineural presente, não tendo eficácia comprovada após a cirurgia de Mohs 17 .…”

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Tumor de colisão de pele do pescoço

Chedid

Menezes

Aikawa

et al. 2011

Rev. Col. Bras. Cir.

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ABSTRACT ABSTRACT ABSTRACTThe collision or mixed tumor is a malignant neoplasm of the skin related to sun exposure and incidence rates of up to 1.5%. It displays a distinctive clinical behavior in relation to other malignancies of the skin and the histological diagnosis, characterized by the collision between a basal cell carcinoma and squamous cell carcinoma, i.e., two malignancies with distinct histologies and sharp interface between them. The case reported was of a male, 73-year-old patient, with two cervical lesions progressively growing in recent months. The chosen treatment was surgery. Histological examination showed the presence of squamous cell carcinoma adjacent to basal cell carcinoma. These tumors preferentially occur in light-skinned men in the fifth or sixth decades of life. Their most common location is in the head and neck, especially in the central part of the face. The differential diagnosis of basal-squamous carcinoma is defined by distinct histological criteria, since both tumors have similar clinical behavior. Local recurrence rates vary from 12% to 45%, whereas regional ones are of approximately 7.5%. The main prognostic factors are gender, surgical margins, perineural infiltration and lymph node status. The treatment of choice is resection, radiotherapy being indicated as adjuvant or to inoperable lesions. Local recurrence is the main limiting factor in disease-free survival, with poor results.

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Basosquamous carcinoma

Martin

Edwards

Cawte

et al. 2000

Cancer

132

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BACKGROUND Basosquamous carcinoma is a rare malignancy, with features of both basal cell carcinoma and squamous cell carcinoma. Some authors believe that basosquamous carcinoma merely is a variant of basal cell carcinoma, whereas others have suggested that basosquamous carcinoma may behave more aggressively. To the authors' knowledge the largest published series to date, comprised of 35 cases, was reported > 20 years ago. The authors reviewed their recent experience with basosquamous carcinoma to identify prognostic factors influencing recurrence. METHODS The medical records of all patients with the diagnosis of basosquamous carcinoma treated at the University of Louisville‐affiliated hospitals between 1985–1988 were reviewed by a senior pathologist. Prognostic factors were analyzed using Cox regression analysis and the log rank test. RESULTS Thirty‐one cases of basosquamous carcinoma were identified in 28 patients. The median age at diagnosis was 68 years (range, 10–94 years). The median follow‐up was 60 months (range, 12–312 months). Seventy‐five percent of cases were located on the face, neck, and scalp. One patient had regional lymph node metastasis synchronous with the primary tumor. Patterns of recurrence were: local recurrence only (five patients), local recurrence plus regional lymph nodes (three patients), and pulmonary plus regional lymph nodes (one patient). One patient died of pulmonary metastasis. Significant factors predictive of recurrence (P < 0.01) were male gender, positive surgical resection margin, lymphatic invasion, and perineural invasion. Although tumor size was not a statistically significant factor overall (P = 0.076), the 3 patients with lymph node metastases had large tumors (measuring 2 cm, 5 cm, and 5 cm, respectively). CONCLUSIONS Basosquamous carcinoma is an aggressive epithelial neoplasm with a propensity for local recurrence and potential for distant metastatic spread. This behavior differs substantially from basal cell carcinoma. Complete resection with negative surgical margins is essential. Long term follow‐up for the detection of local recurrence and distant metastatic spread is recommended. Cancer 2000;88:1365–9. © 2000 American Cancer Society.

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Cutaneous Basosquamous Carcinoma of the Head and Neck: A Comparative Analysis

Cited by 70 publications

References 3 publications

Metatypical Carcinoma of the Lower Eyelid

Metatypical Carcinoma of the Lower Eyelid

Tumor de colisão de pele do pescoço

Basosquamous carcinoma

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