Cutaneous basal cell carcinoma arising within a keloid scar: a case report

Goder, Maya; Kornhaber, Rachel; Bordoni, Daniele; Winkler, Eyal; Haik, Josef; Tessone, Ariel

doi:10.2147/ott.s113724

Cited by 14 publications

(2 citation statements)

References 22 publications

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“…It was found that inhibition of mTOR can reduce extracellular matrix deposition [ 20 , 21 ]. In addition, the expression of mTOR and its upstream molecules PI3K and Akt were significantly increased in keloid tissues [ 3 , 4 ].…”

Section: Discussionmentioning

confidence: 99%

Wubeizi Ointment Suppresses Keloid Formation through Modulation of the mTOR Pathway

Tang

Cao

Ding

et al. 2020

BioMed Research International

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Background. Wubeizi (Rhus chinensis Mill.) ointment has been shown as an effective treatment for keloids. However, the protective mechanisms of Wubeizi ointment are not fully understood. The mammalian target of rapamycin (mTOR) has been demonstrated to be associated with keloid pathogenesis. In the present study, we investigated if Wubeizi ointment suppressed keloid formation through the modulation of key molecules of the rapamycin (mTOR) pathway including phosphatase and tensin homolog (PTEN), phosphatidylinositol 3-kinase (PI3K), and protein kinase B (Akt). Methods. A keloid mouse model and human keloid-derived fibroblasts were developed and treated with Galla chinensis. Immunohistochemistry, western blot, and reverse transcription-PCR were used to detect PI3K, PTEN, Akt, and mTOR in keloid tissues and keloid fibroblasts. The apoptosis and proliferation rate of keloid fibroblasts was, respectively, analyzed by flow cytometry according to the MTT assay. Statistical analysis was done using SPSS version 20.0. For two variable comparisons, a two independent samples t-test was used. For multiple variable comparisons, data were analyzed by one-way analysis of variance (ANOVA) followed by pairwise q-tests. Results. Our in vivo and in vitro studies showed that Wubeizi ointment suppressed keloid formation through inhibition of fibroblast proliferation and promotion of fibroblast apoptosis. The underlying basis involves downregulation of p-Akt and p-mTOR as well as upregulation of PTEN. Conclusion. These findings may contribute to a better understanding of the mechanisms of Wubeizi ointment for treating keloids.

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Section: Discussionmentioning

confidence: 99%

Wubeizi Ointment Suppresses Keloid Formation through Modulation of the mTOR Pathway

Tang

Cao

Ding

et al. 2020

BioMed Research International

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“…The observations are consistent with disturbance being a fundamental factor [93] in tumour initiation. Further, an association between keloids and cancer has been reported [112, 113]. There are, of course, many occasions where scars are not sites of subsequent tumour growth, probably reflecting that for cancerous behaviour to occur, the disturbance of ECM must be accompanied by a loaded tissue-specific oncogene that has potential to elicit uncontrolled proliferation in that tissue (Fig.…”

Section: Disrupted Ecm and Cancermentioning

confidence: 99%

Tumour Initiation: a Discussion on Evidence for a “Load-Trigger” Mechanism

Evans

Alkaisi

Sykes

2019

Cell Biochem Biophys

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Appropriate mechanical forces on cells are vital for normal cell behaviour and this review discusses the possibility that tumour initiation depends partly on the disruption of the normal physical architecture of the extracellular matrix (ECM) around a cell. The alterations that occur thence promote oncogene expression. Some questions, that are not answered with certainty by current consensus mechanisms of tumourigenesis, are elegantly explained by the triggering of tumours being a property of the physical characteristics of the ECM, which is operative following loading of the tumour initiation process with a relevant gene variant. Clinical observations are consistent with this alternative hypothesis which is derived from studies that have, together, accumulated an extensive variety of data incorporating biochemical, genetic and clinical findings. Thus, this review provides support for the view that the ECM may have an executive function in induction of a tumour. Overall, reported observations suggest that either restoring an ECM associated with homeostasis or targeting the related signal transduction mechanisms may possibly be utilised to modify or control the early progression of cancers. The review provides a coherent template for discussing the notion, in the context of contemporary knowledge, that tumourigenesis is an alliance of biochemistry, genetics and biophysics, in which the physical architecture of the ECM may be a fundamental component. For more definitive clarification of the concept there needs to be a phalanx of experiments conceived around direct questions that are raised by this paper.

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Autofluorescence imaging for recurrence detection in skin cancer postoperative scars

Tamošiūnas

Plorina

Lange

et al. 2020

Journal of Biophotonics

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This clinical study is a first attempt to use autofluorescence for recurrence diagnosis of skin cancer in postoperative scars. The proposed diagnostic parameter is based on a reduction in scar autofluorescence, evaluated in the green spectral channel. The validity of the method has been tested on 110 postoperative scars from 56 patients suspected of non‐melanoma skin cancer, with eight patients (13 scars) available for the repeated examination. The recurrence diagnosis within a scar has been made after two subsequent autofluorescence check‐ups, representing the temporal difference between the scar autofluorescence amplitudes as a vector. The recognition of recurrence has been discussed to represent the significant deviations from the value of vector angle θ. This new autofluorescence‐based method can be easily integrated into the postoperative monitoring of surgical scars and can help diagnose the recurrence of skin cancer from the early stage of scar development.

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Cutaneous basal cell carcinoma arising within a keloid scar: a case report

Cited by 14 publications

References 22 publications

Wubeizi Ointment Suppresses Keloid Formation through Modulation of the mTOR Pathway

Wubeizi Ointment Suppresses Keloid Formation through Modulation of the mTOR Pathway

Tumour Initiation: a Discussion on Evidence for a “Load-Trigger” Mechanism

Autofluorescence imaging for recurrence detection in skin cancer postoperative scars

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