Autofluorescence imaging for recurrence detection in skin cancer postoperative scars

Abstract

This clinical study is a first attempt to use autofluorescence for recurrence diagnosis of skin cancer in postoperative scars. The proposed diagnostic parameter is based on a reduction in scar autofluorescence, evaluated in the green spectral channel. The validity of the method has been tested on 110 postoperative scars from 56 patients suspected of non‐melanoma skin cancer, with eight patients (13 scars) available for the repeated examination. The recurrence diagnosis within a scar has been made after two subsequent autofluorescence check‐ups, representing the temporal difference between the scar autofluorescence amplitudes as a vector. The recognition of recurrence has been discussed to represent the significant deviations from the value of vector angle θ. This new autofluorescence‐based method can be easily integrated into the postoperative monitoring of surgical scars and can help diagnose the recurrence of skin cancer from the early stage of scar development.

Metabolic heterogeneity protects metastatic mucosal melanomas cells from ferroptosis

“…Increased NAdH and NAdPH accumulation not only functions as an antioxidant, but also increases autofluorescence (72,73). High levels of autofluorescence were confirmed in cOMM-SUS cells in the present study.…”

Quantitative Multispectral Imaging Differentiates Melanoma from Seborrheic Keratosis

“…The use of MSI in the field of dermatology has been emerging in the last two decades. An LED-based MSI device was recently successfully introduced for the detection of recurring skin cancers [43,44] and proved to be applicable in the differentiation of different tumor types from benign lesions based on their mean intensity of autofluorescence (AF) [45]. In addition, MSI has been also utilized for the detection of rare skin disorders [46,47].…”

Skin's green autofluorescence at dorsal centremetacarpus may become a novel biomarker for diagnosis of lung cancer

“…The AF of the tissues may also be used for diagnosis of several diseases, including oral cancer [20] and macular dystrophy [21]. It has been reported that the AF of the skin cancer postoperative scars could be used for predicting recurrence of the cancer [22]. However, there has been no study that has shown that the AF of certain positions of the skin may be used for diagnosis of the disease of certain organs such as lung cancer.…”