Cutaneous Anthrax

A Short Course of Antibiotic Treatment Is Effective in Preventing Death from Experimental Inhalational Anthrax after Discontinuing Antibiotics

“…However, as reported previously and as expected, a serological response develops in individuals who are treated and recover from established clinical anthrax [11][12][13]. Furthermore, repeated cutaneous B. anthracis infections have rarely been reported and tend to be much milder [14]. This suggests that the initial B. anthracis infection induces some degree of immunity that protects against the development of subsequent disease.…”

Anthrax

“…How¬ ever, Hodgson has reported such cases. 11 Experimentally, only protection tests can be used to measure immunity, and this method has been employed by Wright and his associates 12 to determine in animals the value of an alum-precipitated protective anti¬ gen which they have prepared by growing a nonproteolytic mutant strain of anthrax ba¬ cillus in a chemically-defined nonprotein medium. At present, we are engaged in a field study to determine the value of this anti¬ gen in the prevention of anthrax among workers exposed to this disease.…”

Passive protection against anthrax in mice with plasma derived from horses hyper-immunized againstBacillus anthracisSterne strain

“…The first report of successful treatment using Sclavo’s anti-serum appeared in the British Medical Journal in 1905 describing the treatment and recovery of a man with cutaneous anthrax ( Mitchell, 1905 ). Reports of the observational success of anti- serum in the treatment of cutaneous and systemic anthrax continued up until 1954 ( Hodgson, 1941 ; Canright, 1928 ; Santee, 1923 ; Sclavo, 1954 ). Equine-based hyperimmune products continue to be important therapeutic modalities for toxin based diseases such tetanus, botulism, and snake envenomation, as well as some viral disease such rabies ( Arnon, 2007 ; CDC, 2010 ; CDC, 2011 ).…”