Cutaneous angiomyolipoma: report of two cases with emphasis on HMB‐45 utility

Büyükbabanı, Nesimi; Tetikkurt, Seza; Ozturk, As

doi:10.1111/j.1468-3083.1998.tb00769.x

Cited by 18 publications

(6 citation statements)

References 9 publications

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“…Our tumor was HMB‐45 negative which is consistent with other reported cutaneous angiomyolipomas 8,9 . The reason for this discrepancy is still unclear but has been speculated to be related to a relative lack of epithelioid components within the tissue of cutaneous angiomyolipomas 9 …”

Section: Discussionsupporting

confidence: 86%

“…Pathological diagnosis of cutaneous angiomyolipomas often spurs the physician to hunt for tuberous sclerosis stigmata on the patient. Review of the published work revealed only 17 reported cases of cutaneous angiomyolipoma, including our own, and none have been associated with tuberous sclerosis to date 3–10 . Other extra‐renal angiomyolipomas have been described in locations such as the liver, spleen, lymph nodes, penis, vagina, fallopian tube, oral and nasal cavities, lung, heart, colon and mediastinum 8 .…”

Section: Introductionmentioning

confidence: 94%

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Management of cutaneous angiomyolipoma and its association with tuberous sclerosis

DeBloom

Friedrichs

Swick

et al. 2006

The Journal of Dermatology

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Although typically presenting renally, angiomyolipomas can rarely present in the skin. The tumors are composed of an admixture of blood vessels, smooth muscle and adipose tissue and are often seen in the setting of tuberous sclerosis. We describe a case of angiomyolipoma presenting on the thigh of a 50-year-old white female. This is the 17th reported case of cutaneous angiomyolipoma. As with all previously described cases, our patient did not present with the stigmata of tuberous sclerosis. Angiomyolipoma should be considered within the differential for subcutaneous nodules and work-up for tuberous sclerosis should not be pursued when presenting in the skin.

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Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 94%

Management of cutaneous angiomyolipoma and its association with tuberous sclerosis

DeBloom

Friedrichs

Swick

et al. 2006

The Journal of Dermatology

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“…HMB-45 reactivity, reported for renal angiomyolipomas, has been suggested as a useful tool in differential diagnosis. Buyukbabani et al conclude that, unlike renal angiomyolipomas, HMB-45 reactivity is not helpful in differentiating cutaneous angiomyolipomas [8].…”

Section: Discussionmentioning

confidence: 99%

“…Extrarenal sites of angiomyolipoma include the liver [3,4], spleen [5], retroperitoneum [6], lymph nodes [3] and spermatic cord [7]. The subcutaneous angiomyolipoma is very rare [8,9,10,11]. In 1990, Fitzpatrick et al described eight cases of cutaneous angiolipoleiomyoma ("angiomyolipoma").…”

Section: Discussionmentioning

confidence: 99%

Angiomyolipoma in the Knee-A Case Report

Hatori

Watanabe

Kokubun

2005

Upsala Journal of Medical Sciences

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Extrarenal angiomyolipoma is an uncommon disease and this may be the first report of angiomyolipoma in the knee, mimicking a malignant sarcoma. A 38-year-old man without tuberous sclerosis presented with a history of increased mass in the knee joint. Computerized tomography and magnetic resonance imaging demonstrated a ÇS x ÇS x ÇR cm subcutaneous tumor in the knee joint. The tumor was widely excised. Histologically, the tumor was, well circumscribed, and composed of smooth muscle, vascular spaces, connective tissue, and mature fat. There were no signs of recurrence at one year and eight months after surgery.

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“…The ear has been reported to be the commonest site of cutaneous AML on the head and neck region followed by eye, lip, glabella, pre-auricular and post-auricular region and less commonly, the nose [4]. There are only 2 reported cases of cutaneous AML of the external nasal pyramid in literature till date (Buyukbabani et al and Obata et al) [5] [6]. Cutaneous AML unlike renal type predominantly affects male; is solitary, non-invasive, and negative for human melanoma black (HMB)-45 antibody and is not associated with tuberous sclerosis.…”

Section: Introductionmentioning

confidence: 99%