Cutaneous and Systemic Porcine Mastocytosis

Bundza, A.; Dukes, Thomas W.

doi:10.1177/030098588201900412

Cited by 17 publications

(14 citation statements)

References 7 publications

(5 reference statements)

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“…This finding corresponds with data from reports about mast cell tumors, respectively, mastocytosis in other species, that is, dog (8,13,22), horse (20), pig (6), and cow (2). In the cat, eosinophil accumulation has been described in association with the so-called histiocytic type mastocytoma (28 Gastroduodenal ulceration associated with the release of histamine, produced by neoplastic mast cells, which can result in increased secretion of gastric acid and possibly local mucosal ischemia, is reported in dog, cat, and humans (8).…”

supporting

confidence: 90%

Brief Communication

1996

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supporting

confidence: 90%

Brief Communication

1996

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Section: Pig (Sus Scrofa Domesticus)mentioning

confidence: 99%

“…Mast cell neoplasia in pigs is rarely reported and can range from well differentiated, benign lesions to malignant and metastatic cancer (Bundza & Dukes, 1982;Newman & Rohrbach, 2012). In one study, multiple cutaneous and visceral MCTs were reported in three pigs, two of which were simultaneously diagnosed with eperythrozoonosis (Bundza & Dukes, 1982). In a recent case report, staining with Toluidine Blue or Giemsa was inconclusive and the diagnosis of MCT was based on positive Kit and tryptase immunohistochemistry (Williams, Annetti, & Nagy, 2018).…”

Section: Pig (Sus Scrofa Domesticus)mentioning

confidence: 99%

Comparative aspects of mast cell neoplasia in animals and the role of KIT in prognosis and treatment

Tamlin

Bottema

Peaston

2019

Veterinary Medicine & Sci

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Mast cell neoplasia clinical presentation and biological behaviour vary considerably across mammalian species, ranging from a solitary benign mass to an aggressive systemic malignancy. Mutations in the KIT Proto‐Oncogene Receptor Tyrosine Kinase (KIT) gene are common molecular abnormalities involved in mast cell tumorigenesis. KIT mutations often occur in dog, cat and human neoplastic mast cells and result in altered Kit protein structure and function. In dogs, certain KIT mutations are associated with more malignant and lethal disease. In contrast, KIT mutations in feline and human mast cell neoplasms are not correlated with prognosis, but are of value in diagnosis and treatment planning in humans. KIT genetic abnormalities have not been well investigated in other species, although aberrant cytoplasmic Kit protein staining detected in neoplasms of the ferret, horse and cow resembles aberrant Kit staining patterns detected in neoplastic mast cells of dogs, cats and humans. Mutations within KIT are classified as either regulatory‐type or enzymatic pocket‐type mutations according to their location within the KIT Proto‐Oncogene. Mutations within the enzymatic pocket domain confer tumour resistance to tyrosine kinase inhibitors (TKIs). Hence, knowledge of tumour KIT mutation status adds valuable information for optimizing patient treatment strategies. The use of TKIs in combination with conventional chemotherapeutics has opened a new treatment avenue for patients unresponsive to existing drugs. This review highlights the similarities and differences of mast cell neoplasia in mammals with a special focus on the involvement of KIT in the canine and feline forms in comparison to human mast cell neoplasia.

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“…Five 2-to 2.4-year-old Japanese Black steers (case Nos. [1][2][3][4][5] were brought to an abattoir from 5 different feedlots. Each animal was conventionally slaughtered on separate days over a 9-month period.…”

mentioning

confidence: 99%

Hepatic Mastocytosis in Japanese Black Cattle

Ohfuji¹

2017

Vet Pathol

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In 5 Japanese Black steers (2-2.4 years old) that originated from 5 different feedlots, the livers were found at slaughter to have multiple nodular or cordlike lesions (5 steers) and an extensive fibrotic area (1 steer). Microscopic changes included extensive fibroplasia in the portal tracts and chronic proliferative endophlebitis-like lesions confined to the portal vein branches. Fibroplasia was much more prominent in the macroscopic fibrotic lesion of 1 steer. Portal vein branches presented irregular variciform dilation of the vascular lumen and fibroplastic changes in the subendothelial areas that showed occasional hemorrhage and were simultaneously infiltrated with large numbers of mast cells and moderate to large numbers of eosinophils. Within these subendothelial regions, not only did mast cells exhibit cytologically atypical features, but they also formed multifocal nodules. The venous lesions may represent a variant of mastocytosis with specific involvement of the hepatic portal vein branches in cattle.

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Cutaneous and Systemic Porcine Mastocytosis

Cited by 17 publications

References 7 publications

Brief Communication

Brief Communication

Comparative aspects of mast cell neoplasia in animals and the role of KIT in prognosis and treatment

Hepatic Mastocytosis in Japanese Black Cattle

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