Cutaneous and subcutaneous leiomyosarcoma: a clinicopathological review of 14 cases with reference to antidesmin staining and nuclear DNA patterns studied by flow cytometry

Oliver, G. Fergus; Reiman, Herbert M.; Gonchoroff, Nick J.; Muller, Sigfrid A.; Umbert, Ignacio J.

doi:10.1111/j.1365-2133.1991.tb00569.x

Cited by 59 publications

(28 citation statements)

References 23 publications

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“…Similarly, in humans, 68-100% and 43-100% of dermal leiomyosarcomas have been reported to label for ␣-SMA and desmin, respectively. 10,18,20,24,29 The absence of labeling for these two markers does not definitively rule out a diagnosis of leiomyosarcoma. Also, other canine spindle cell tumors, such as hemangiopericytomas 14,19 and a variety of tumors in humans (including primitive neuroectodermal tumors, neuroblastomas, giant cell tumors of tendon sheaths, mesotheliomas, tumors of myofibroblast origin, and osteosarcomas), have been reported to express ␣-SMA and/or desmin.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Smooth Muscle Tumors in the Dog and Cat

Liu

Mikaelian

2003

Vet Pathol

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Abstract. Cutaneous smooth muscle tumors may arise from arrector pili muscles and from smooth muscles of the dermal vasculature. This report describes histologic and immunohistochemical features of eight arrector pili hamartomas in 8 dogs, 15 piloleiomyomas in 10 dogs and 3 cats, 10 piloleiomyosarcomas in 9 dogs and 1 cat, 1 angioleiomyoma in 1 cat, and 9 angioleiomyosarcomas in 6 dogs and 3 cats. Hamartomas and tumors arising from arrector pili muscles preferentially originated from the dorsal trunk. 5/5 (100%) arrector pili hamartomas, 10/12 (83%) piloleiomyomas, 4/5 (80%) piloleiomyosarcomas, 1/1 (100%) angioleiomyoma, and 6/7 (86%) angioleiomyosarcomas were positive for smooth muscle actin. 5/5 (100%) arrector pili hamartomas, 10/12 (83%) piloleiomyomas, 4/5 (80%) piloleiomyosarcomas, 1/1 (100%) angioleiomyoma, and 1/7 (14%) angioleiomyosarcomas were positive for desmin. Two incompletely excised canine angioleiomyosarcomas recurred locally. Metastases were not reported.

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Section: Discussionmentioning

confidence: 99%

Cutaneous Smooth Muscle Tumors in the Dog and Cat

Liu

Mikaelian

2003

Vet Pathol

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“…In humans, females are affected more often than males, with a sex ratio of 1.7 11 to 3.7. 10 The cause of this difference is unknown.…”

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“…Similarly, well-differentiated piloleiomyosarcomas in humans have a low potential for local recurrence and metastasis. 10 Longterm survival was compromised by the development of an adrenocortical tumor in 3 of 5 ferrets. The development of an adrenal tumor in these animals is considered a coincidental finding, because adrenal tumors are the second most common type of tumor in aging ferrets.…”

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confidence: 99%

Solitary Dermal Leiomyosarcomas in 12 Ferrets

Mikaelian

Garner

2002

J VET Diagn Invest

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Twelve 3–6-year-old ferrets (8 males, 3 females, 1 unknown) were presented with single cutaneous nodules. These dermal tumors were characterized histologically by nodular proliferation of neoplastic smooth muscle fibers with marked anisokaryosis and a mitotic rate of >2 mitoses per 10 high-power fields. Neoplastic cells stained strongly for vimentin in all tumors and for smooth muscle actin and desmin in all but 1 tumor. Histologic and immunohistochemical findings suggested a diagnosis of piloleiomyosarcoma for these tumors. Excision was curative in all animals available for follow-up. However, 3 of 5 animals developed adrenal disease within 7 months after removal of the dermal leiomyosarcoma.

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“…Only a few LMS studies 4,[8][9][10][11][12][13] of any significant size included clinical and follow-up data, and several others [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] analyzed limited numbers of patients with primary LMS at these sites. In addition, many of the previous studies are difficult to interpret, because heterogeneous tumor groups were studied without specifying the localization relative to skin or fascia or the anatomic site.…”

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confidence: 99%

Clinical course of nonvisceral soft tissue leiomyosarcoma in 225 patients from the Scandinavian Sarcoma Group

Svarvar¹,

Böhling²,

Berlin³

et al. 2007

Cancer

124

132

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BACKGROUND.Leiomyosarcoma of nonvisceral soft tissues is an uncommon malignant tumor; thus, only small numbers of cases have been reported. This study was based on a large series of patients from the Scandinavian Sarcoma Group Register acquired during a 15‐year period (from 1986 to 2001). Follow‐up information was available for all patients.METHODS.The authors analyzed the clinical features of 225 patients with cutaneous, subcutaneous, or deep‐seated leiomyosarcoma of the extremities, trunk wall, and superficial parts of the head and neck region to determine the natural course of the disease. Only patients who received their treatment at a specialist sarcoma center were included. Re‐evaluation of histopathology was performed.RESULTS.The age of the patients (121 women and 104 men) ranged from 20 years to 98 years (median, 70 years), and the tumors ranged in size from 0.6 cm to 35 cm (median, 4.0 cm). Eighty‐two percent of the tumors were classified as high grade. The median follow‐up for survivors was 5.5 years. The local treatment was adequate in 154 of 206 patients (75%) who were without metastasis at presentation. At 10 years, 84% of the 206 patients with localized disease at presentation were free from local recurrence, 66% remained metastasis free, and 49% were alive. Multivariate analysis showed that higher malignancy grade (P = .006), larger tumor size (P = .003), and deeper tumor location (P = .002) were correlated significantly with decreased metastasis‐free survival, inadequate local treatment was correlated with local recurrence (P = .007), and high malignancy grade was correlated with decreased overall survival (P = .007).CONCLUSIONS.The long‐term prognosis for patients with subcutaneous and deep‐seated soft tissue leiomyosarcoma remains poor despite the ability to achieve adequate local control through nonmutilating surgery with or without radiotherapy. Cancer 2007. © 2006 American Cancer Society.

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Cutaneous and subcutaneous leiomyosarcoma: a clinicopathological review of 14 cases with reference to antidesmin staining and nuclear DNA patterns studied by flow cytometry

Cited by 59 publications

References 23 publications

Cutaneous Smooth Muscle Tumors in the Dog and Cat

Cutaneous Smooth Muscle Tumors in the Dog and Cat

Solitary Dermal Leiomyosarcomas in 12 Ferrets

Clinical course of nonvisceral soft tissue leiomyosarcoma in 225 patients from the Scandinavian Sarcoma Group

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