Cutaneous adverse drug reactions with fixed-dose combinations: Special reference to self-medication and preventability

Tripathy, Ratikanta; Pattnaik, Kali Prasad; Dehury, Suhasini; Patro, Sibasis; Mohanty, Prasanjeet; Sahoo, Satyabrata; Mohanty, Srikanta

doi:10.4103/ijp.ijp_760_16

Cited by 5 publications

(1 citation statement)

References 7 publications

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“…and Kornmehl et al . [ 5 6 ] According to studies done by Mahboob et al . and others, 16% of patients had a single plaque, 36% had two to five plaques, and 47% had more than five plaques on initial presentation.…”

Section: Discussionmentioning

confidence: 99%

A Clinico-Epidemiological Study of Fixed Drug Eruption with a Special Focus on the Causative Agent and the Clinical Patterns

Halder,

Das,

2024

Indian Dermatology Online Journal

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Background: Fixed drug reaction (FDE) is characterized by the development of well-circumscribed, round, erythematous macules and plaques on cutaneous or mucosal surface following ingestion of the offending drug. Aim and Objectives: To study the etiological agents responsible for FDE and to study the clinical patterns of FDE due to different drugs. Materials and Methods: It was a hospital-based observational cross-sectional clinical study. The study period was 24 months. Fifty patients were included. The study was done after a literature search, hypothesis generation, protocol write-up, ethical submission, ethical clearance, patient enrollment, data collection, data analysis, and research. The patients were selected on the basis of the Naranjo scoring system. The patients with a history of combination drug intake were not included in the study. Results: A total of 0.11% patients presented with FDE in the study period. Out of them, 52% of the patients belonged to 20–39 years age group, having sex ratio of 1.6:1. About 64% of the patients presented with multiple lesions, whereas 36% had a single lesion. A total of 46% patients presented with first episode and 54% had recurrent episodes. The mean time intervals of first and subsequent episodes were 6.5 days and 4.3 hours, respectively. Also, 16% patients had a history of herpes infection. Extremities were more affected followed by trunk and mucosa. Fluoroquinolones were the most common etiological agent found in 56% patients having cutaneous (48%) and mucosal lesions (14%). The most common drug was norfloxacin (36%) followed by both paracetamol (12%) and metronidazole (12%). Fluoroquinolones were the most common drugs implicated in bullous lesions and generalized bullous FDE. Limitations: The study population was small and the study was for a limited period of time. Conclusion: The patient should be aware of the offending drug and opt for any alternative agent after visiting the physician.

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Section: Discussionmentioning

confidence: 99%