Customized trapping of magnetic particles

Ramadan, Qasem; Poenar, Daniel Puiu; Chen, Yu

doi:10.1007/s10404-008-0296-2

Cited by 48 publications

(44 citation statements)

References 24 publications

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“…Photolithographic techniques enable fabrication of almost any desired MET geometry; as a result the geometry of an MET can be tuned for a specific application. Ramadan et al [18,[21][22][23][24][25][26][27] and Lee et al [20,28] have demonstrated customized MP traps which emphasize the effects of different MET geometries. Simulations of magnetic fields produced by different MET geometries have magnetic field profiles attributed to the shape of the MET and magnetic coupling between conductors or loops.…”

Section: Geometrymentioning

confidence: 95%

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Applications of microelectromagnetic traps

Basore

Baker

2012

Anal Bioanal Chem

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Microelectromagnetic traps (METs) have been used for almost two decades to manipulate magnetic fields. Different trap geometries have been shown to produce distinct magnetic fields and field gradients. Initially, microelectromagnetic traps were used mainly to separate and concentrate magnetic material at small scales. Recently such traps have been implemented for unique applications, for example filterless bioseparations, inductive heat generation, and biological detection. In this review, we describe recent reports in which MET geometry, current density, or external fields have been used. Descriptions of recent applications in which METs have been used to develop sensors, manipulate DNA, or block ion current are also provided.

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Section: Geometrymentioning

confidence: 95%

“…1) are discussed to illustrate the effect of MET geometry on magnetic field and magnetic gradient [21]. Additional MET configurations exist, but are not described beyond these basic designs.…”

Section: Geometrymentioning

confidence: 97%

Applications of microelectromagnetic traps

Basore

Baker

2012

Anal Bioanal Chem

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“…13 This approach enables dynamic reconfiguration of the magnetic field patterns, but has the drawback of generating Joule heating, which limits considerably the maximum value of generated magnetic field, and thus field gradient, and may have adverse effects on cell viability.…”

Section: B)mentioning

confidence: 99%

Microfluidic immunomagnetic cell separation using integrated permanent micromagnets

et al. 2013

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In this paper, we demonstrate the possibility to trap and sort labeled cells under flow conditions using a microfluidic device with an integrated flat micro-patterned hard magnetic film. The proposed technique is illustrated using a cell suspension containing a mixture of Jurkat cells and HEK (Human Embryonic Kidney) 293 cells. Prior to sorting experiments, the Jurkat cells were specifically labeled with immunomagnetic nanoparticles, while the HEK 293 cells were unlabeled. Droplet-based experiments demonstrated that the Jurkat cells were attracted to regions of maximum stray field flux density while the HEK 293 cells settled in random positions. When the mixture was passed through a polydimethylsiloxane (PDMS) microfluidic channel containing integrated micromagnets, the labeled Jurkat cells were selectively trapped under fluid flow, while the HEK cells were eluted towards the device outlet. Increasing the flow rate produced a second eluate much enriched in Jurkat cells, as revealed by flow cytometry. The separation efficiency of this biocompatible, compact micro-fluidic separation chamber was compared with that obtained using two commercial magnetic cell separation kits.

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“…8,9 However, these techniques make use of external magnets that are difficult to integrate in lab-on-a-chip approaches. Alternatively, current carrying microwires [10][11][12][13][14][15][16][17] or on-chip magnetic patterns in combination with switching external fields [18][19][20] have been employed for localized particle actuation. A very flexible approach to control the position of magnetic particles on a chip without external magnets is given by microwire crossbar arrays as introduced by the group of Westervelt.…”

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confidence: 99%

Actuation and tracking of a single magnetic particle on a chip

Rinklin

Krause

Wolfrum

2012

Applied Physics Letters

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We present the defined actuation of a single magnetic particle on a crossbar array chip. Two orthogonal layers of parallel microwires are used to generate highly localized magnetic field gradients for particle trapping and movement. We introduce an analytical model to simulate the actuation of the particle, which is in precise agreement with the experimentally observed trajectory. The single-particle approach allows us to resolve subtle features of the induced magnetic field distribution. We demonstrate that the actuation strongly depends on the applied current sequence and introduce switching patterns for reliable control of an individual particle.

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Customized trapping of magnetic particles

Cited by 48 publications

References 24 publications

Applications of microelectromagnetic traps

Applications of microelectromagnetic traps

Microfluidic immunomagnetic cell separation using integrated permanent micromagnets

Actuation and tracking of a single magnetic particle on a chip

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