Customizable engineered blood vessels using 3D printed inserts

Pinnock, Cameron B.; Meier, Elizabeth M.; Joshi, Neeraj; Wu, Bin; Lam, Mai T.

doi:10.1016/j.ymeth.2015.12.015

Cited by 44 publications

(37 citation statements)

References 18 publications

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“…More recently experimental comparisons have been presented by Gleadall et al [22], who employ a new computationallyefficient method based on conservation of volume to predict the geometry of a 3D lattice, and Comminal et al [23], who employ a full (isothermal) computational fluid dynamics (CFD) model of a single deposited filament. Extrusion of single polymer filaments has many applications including antenna manufacture with conductive filaments [24], custom polymer vascular inserts [25] as well as scaffolding structures [26] for the initial layers of the FFF process.…”

mentioning

confidence: 99%

A method for predicting geometric characteristics of polymer deposition during fused-filament-fabrication

Hebda

McIlroy

Whiteside

et al. 2019

Additive Manufacturing

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In recent years 3D printing has gained popularity amongst industry professionals and hobbyists alike, with many new types of Fused Filament Fabrication (FFF) apparatus types becoming available on the market. A massively overlooked component of FFF is the requirement for a simple method to calculate the geometries of polymer depositions extruded during the FFF process. Manufacturers have so far achieved adequate methods to calculate tool-paths through so called slicer software packages which calculate the required velocities of extrusion from prior knowledge and data. Presented here is a method for obtaining a series of equations for predicting height, width and cross-sectional area values for given processing parameters within the FFF process for initial laydown on to a glass surface.

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mentioning

confidence: 99%

A method for predicting geometric characteristics of polymer deposition during fused-filament-fabrication

Hebda

McIlroy

Whiteside

et al. 2019

Additive Manufacturing

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“…Such matrices can be worked into desired shapes using micromolding, microfluidics, electrostatic droplet extrusion, or bioprinting (Kim et al, 2019). MSC based scaffolds systems have been used for bone and cartilage regeneration (Kim et al, 2019), as well as for the reproduction of blood vessels (Pinnock et al, 2016), cardiac tissue (Rashedi et al, 2017;Ichihara et al, 2018;Joshi et al, 2018), and skeletal muscle (Witt et al, 2017). Optimal tissue replacement efficiency relies on the physical characteristics of the scaffolds (Alakpa et al, 2017;Jeon et al, 2017;Mouser et al, 2018), as each mechanical property can modify the fate of the transplanted cells.…”

Section: Alternative Approaches To Msc Administrationmentioning

confidence: 99%

Five Decades Later, Are Mesenchymal Stem Cells Still Relevant?

Gomez-Salazar

Gonzalez-Galofre

Casamitjana

et al. 2020

Front. Bioeng. Biotechnol.

117

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Mesenchymal stem cells are culture-derived mesodermal progenitors isolatable from all vascularized tissues. In spite of multiple fundamental, pre-clinical and clinical studies, the native identity and role in tissue repair of MSCs have long remained elusive, with MSC selection in vitro from total cell suspensions essentially unchanged as a mere primary culture for half a century. Recent investigations have helped understand the tissue origin of these progenitor cells, and uncover alternative effects of MSCs on tissue healing via growth factor secretion and interaction with the immune system. In this review, we describe current trends in MSC biology and discuss how these may improve the use of these therapeutic cells in tissue engineering and regenerative medicine.

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“…[53,59]. Human aortic smooth muscle cells (HASMCs) were seeded on fibrin hydrogel to self-organize into a tubular form resembling a natural artery ring [60]. The gel, aided by the innate contractile properties of the SMCs, migrated towards the center post insert, creating a tissue ring of SMCs.…”

Section: Fibrin Collagen and Gelatinmentioning

confidence: 99%

3D Printing Applied to Tissue Engineered Blood Grafts

Wenger¹,

Giraud²

2018

Preprint

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The broad clinical use of synthetic vascular grafts for vascular diseases is limited by their thrombogenicity and low patency rate, especially for vessels with a diameter inferior to 6 mm. Alternatives such as tissue-engineered blood grafts (TEBGs) have gained increasing interest. Among the different manufacturing approaches, 3D bioprinting presents numerous advantages and enables the fabrication of multi-scale, multi-material, and multicellular tissues with heterogeneous and functional intrinsic structures. Extrusion-, inkjet- and light-based 3D printing techniques have been used for the fabrication of TEBG out of hydrogels, cells, and/or solid polymers. This review discusses the state-of-the-art research on the use of 3D printing for TEBG with a focus on the biomaterials and deposition methods.

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Customizable engineered blood vessels using 3D printed inserts

Cited by 44 publications

References 18 publications

A method for predicting geometric characteristics of polymer deposition during fused-filament-fabrication

A method for predicting geometric characteristics of polymer deposition during fused-filament-fabrication

Five Decades Later, Are Mesenchymal Stem Cells Still Relevant?

3D Printing Applied to Tissue Engineered Blood Grafts

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