Custom Measurement of Retinal Nerve Fiber Layer Thickness Using STRATUS OCT in Normal Eyes

Carpineto, Paolo; Ciancaglini, Marco; Aharrh-Gnama, Agbéanda; Cirone, Daniele; Mastropasqua, L.

doi:10.1177/112067210501500308

Cited by 32 publications

(47 citation statements)

References 18 publications

(31 reference statements)

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“…Similar results have been already reported, even if in a much smaller sample of eyes [14,21]. Other technology-based studies were conducted [6,28] with Stratus OCT in healthy eyes using RNFL thickness 3.4 and optic disc protocols and it was found that, differently from our findings, thickness increases significantly for increasing OD area [28] and diameter [6]. This discrepancy of results may be interpreted on the basis of differences in ).…”

Section: Discussioncontrasting

confidence: 48%

Correlation between optic disc area and retinal nerve fiber layer thickness: a study on scanning laser polarimetry with variable corneal compensation

Pozzo

Iacono

Michelone

et al. 2006

Graefe's Arch Clin Exp Ophthalmol

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Section: Discussioncontrasting

confidence: 48%

Correlation between optic disc area and retinal nerve fiber layer thickness: a study on scanning laser polarimetry with variable corneal compensation

Pozzo

Iacono

Michelone

et al. 2006

Graefe's Arch Clin Exp Ophthalmol

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“…Another way to adjust for this would be to measure RNFL at a fixed relative distance from the optic disc margin. Carpineto et al 23 performed Stratus OCT measurements using the fixed 3.46-mm-diameter circle and a variable scan circle diameter designed to measure the RNFL 0.85 mm from the edge of the optic disc in the same group of 30 normal eyes. They confirmed the findings of the current studynamely, that eyes with larger optic nerves had thicker RNFL measurements-but also showed that RNFL thickness is unrelated to vertical optic disc diameter if one measures RNFL thickness a fixed distance from the disc margin.…”

Section: Discussionmentioning

confidence: 99%

Determinants of Normal Retinal Nerve Fiber Layer Thickness Measured by Stratus OCT

et al. 2007

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Purpose-To determine the effects of age, optic disc area, ethnicity, eye, gender, and axial length on the retinal nerve fiber layer (RNFL) in the normal human eye as measured by Stratus OCT (optical coherence tomography).Design-Cross-sectional observational study.Participants-Three hundred twenty-eight normal subjects 18 to 85 years old. Methods-PeripapillaryFast RNFL scans performed by Stratus OCT with a nominal diameter of 3.46 mm centered on the optic disc were performed on one randomly selected eye of each subject.Main Outcome Measures-Linear regression analysis of the effects of age, ethnicity, gender, eye, axial length, and optic disc area on peripapillary RNFL thickness.Results-The mean RNFL thickness for the entire population was 100.1 μm (standard deviation, 11.6). Thinner RNFL measurements were associated with older age (P<0.001); being Caucasian, versus being either Hispanic or Asian (P = 0.006); greater axial length (P<0.001); or smaller optic disc area (P = 0.010). For every decade of increased age, mean RNFL thickness measured thinner by approximately 2.0 μm (95% confidence interval [CI], 1.2-2.8). For every 1-mm-greater axial length, mean RNFL thickness measured thinner by approximately 2.2 μm (95% CI, 1.1-3.4). For every increase in square millimeter of optic disc area, mean RNFL thickness increased by approximately 3.3 μm (95% CI, 0.6-5.6). Comparisons between ethnic groups revealed that Caucasians had mean RNFL values (98.1±10.9 μm) slightly thinner than those of Hispanics (103.7±11.6 μm; P = 0.022) or Asians (105.8±9.2 μm; P = 0.043). There was no relationship between RNFL thickness and eye or gender.Correspondence to Donald L. Budenz, MD, MPH, Bascom Palmer Eye Institute, 900 NW 17th Street, Miami, FL 33136. dbudenz@med.miami.edu. Dr Schuman is currently at the Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. Dr Schuman is a co-patent holder of the optical coherence tomography technology. Dr Patella is an employee of Carl Zeiss Meditec. Dr Quigley is a consultant for Carl Zeiss Meditec. NIH Public Access Author ManuscriptOphthalmology. Author manuscript; available in PMC 2010 August 5. Conclusions-Retinal nerve fiber layer thickness, as measured by Stratus OCT, varies significantly with age, ethnicity, axial length, and optic disc area. These variables may need to be taken into account when evaluating patients for diagnosis and follow-up of glaucoma, particularly at the lower boundary of the normal range. Due to the relatively small numbers of subjects of Asian and African descent in the normative database, conclusions regarding the effect of ethnicity should be interpreted with caution.Glaucoma is an optic neuropathy associated with accelerated apoptosis of retinal ganglion cells (RGCs) that manifests as increased cupping of the optic disc and thinning of the retinal nerve fiber layer (RNFL). The diagnosis of glaucoma is currently based on the appearance of the optic disc, RNFL, and standard achromatic perimetry. 1 The optic disc is ...

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“…RNFL thickness reproducibility using OCT has been studied in recent years, and authors have reported good reproducibility (Budenz et al 2005;Carpineto et al 2005). Some authors have studied RNFL measurements reproducibility obtained using the fast RNFL thickness protocol of the Stra- tus 3000 OCT system in healthy (Carpineto et al 2005) and glaucomatous eyes (Blumenthal et al 2000;Budenz et al 2005).…”

Section: Discussionmentioning

confidence: 99%

“…Some authors have studied RNFL measurements reproducibility obtained using the fast RNFL thickness protocol of the Stra- tus 3000 OCT system in healthy (Carpineto et al 2005) and glaucomatous eyes (Blumenthal et al 2000;Budenz et al 2005). Some of these studies reported that nasal RNFL was the less variable sector (Budenz et al 2005).…”

Section: Discussionmentioning

confidence: 99%

Intra and interoperator reproducibility of retinal nerve fibre and macular thickness measurements using Cirrus Fourier-domain OCT

García‐Martín

Pinilla

Idoipe

et al. 2010

Acta Ophthalmologica

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ABSTRACT.Purpose: To test intrasession, intersession, intervisit and interoperator reproducibility of retinal nerve fibre (RNFL) measurements and retinal thickness in healthy subjects using Cirrus Fourier-domain optical coherence tomography (OCT) (Carl Zeiss Meditec, Inc). Methods: Seventy-two eyes of 72 healthy subjects were included in the study. All the eyes underwent three 512 · 128 volume cube centred on the fovea and three 360°circular scans centred on the optic disc by one observer. This sequence was redone by another observer on a second visit within a 2-week period. Descriptive statistics, analysis of variance, intraclass correlation coefficients (ICCs) and coefficients of variation (COVs) were calculated for the nine areas corresponding to the Early Treatment Diabetic Retinopathy Study and for quadrants and RNFL clock hr sectors. Results: Retinal thickness and RNFL measurements were highly reproducible. Mean total retinal thickness was 285.2 ± 15.3 lm by observer 1 and 284.2 ± 12.9 lm by observer 2. Mean COV was 1.2%. Mean RNFL average thicknesses were 96.0 ± 7.7 and 95.7 ± 7.9 lm by observer 1 and 2, respectively. Mean COV was 4.4%. The ICCs ranged from 0.823 to 0.992. Mean differences between both operators were lower than 3 lm, and no significant differences were found. Conclusions: Retinal and RNFL thickness measurements obtained using Cirrus OCT show good repeatability for healthy eyes and few differences between intra-and interobserver evaluations. It can be considered a valid device for measuring retinal and optic nerve parameters in normal eyes.

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Custom Measurement of Retinal Nerve Fiber Layer Thickness Using STRATUS OCT in Normal Eyes

Cited by 32 publications

References 18 publications

Correlation between optic disc area and retinal nerve fiber layer thickness: a study on scanning laser polarimetry with variable corneal compensation

Correlation between optic disc area and retinal nerve fiber layer thickness: a study on scanning laser polarimetry with variable corneal compensation

Determinants of Normal Retinal Nerve Fiber Layer Thickness Measured by Stratus OCT

Intra and interoperator reproducibility of retinal nerve fibre and macular thickness measurements using Cirrus Fourier-domain OCT

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