Cushing's Disease and Cutaneous Alternariosis

Guerin, V.; Barbaud, A.; Duquenne, M.; Contet‐Audonneau, N.; Amiot, Fabienne; Ortega, Françoise; Hartemann, Pierre

doi:10.1001/archinte.1991.00400090137024

Cited by 17 publications

(2 citation statements)

References 19 publications

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“…Infections in patients with underlying immunosuppressive disease, such as diabetes mellitus, Cushing's syndrome, or haematological cancers have also been reported. 8,10,13 Among the Alternaria species responsible for opportunistic infections in organ recipient patients, A. infectoria accounts for only a minority of cases reported over the past decade. 2,3,5,6,9,11,12,14,16,18 Figure 3.…”

Section: Discussionmentioning

confidence: 99%

“…2,3,5,6,9,11,12,14,16,18 Members of this genus are generally found in aerosols, in soil, or on plants, and are typically pathogenic only to immunocompromised hosts. 2,3,5,6,[8][9][10][11][12][13][14][15][16]18 Nevertheless, a few reports describing cutaneous infections among immunocompetent individuals have also been described. 17 The development and refinement of modern molecular biologic techniques have lead to a better genotypic characterization of dematiaceous species associated with phaeohyphomycosis, resulting in a better understanding of these infections over the past decade.…”

Section: Feohifomicosis Producida Por Alternaria Infectoria Con Presementioning

confidence: 99%

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Phaeohyphomycosis caused by Alternaria infectoria presenting as multiple vegetating lesions in a renal transplant patient

Cunha

Amaro

Vieira

et al. 2012

Revista Iberoamericana de Micología

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a b s t r a c tThe genus Alternaria is one of the most common black moulds and appears to be increasing as a causative agent of subcutaneous phaeohyphomycosis, particularly among immunosuppressed patients.A 53-year-old patient who had received a kidney transplant presented with multiple verrucous lesions on the distal extremities. Positive histopathology and cultures, in addition to rDNA ITS region sequencing, identified the fungal isolate as Alternaria infectoria. Oral itraconazole was administered for 10 months. A follow-up at 15 months demonstrated no signs of infection.Clinical manifestations of cutaneous alternariosis vary significantly and only a few cases have been described in the literature. Although optimal treatment options remain controversial, this case of phaeohyphomycosis was successfully treated with itraconazole monotherapy.© 2010 Revista Iberoamericana de Micología. Published by Elsevier España, S.L. All rights reserved.Feohifomicosis producida por Alternaria infectoria con presentación clínica de múltiples lesiones vegetantes en un paciente sometido a un trasplante renal r e s u m e n Las especies del género Alternaria son mohos ubicuos que se caracterizan por presentar colonias de color gris; parecen ser cada vez más frecuentes como agente causal de las feohifomicosis subcutáneas, en especial entre pacientes inmunocomprometidos. Un paciente de 53 años de edad, que se había sometido a un trasplante renal, consultó por presentar tumores verrugosos en el tercio distal de las extremidades. La histopatología y cultivo positivos, además de la secuenciación de la región de transcripción interna ITS del rDNA, permitieron la identificación del aislamiento fúngico como Alternaria infectoria. Se instauró tratamiento con itraconazol oral durante 10 meses y, a los 15 meses de seguimiento, se demostró la ausencia de signos de infección.Las manifestaciones clínicas de la alternariosis cutánea son muy variables y tan sólo se han descrito unos pocos casos en los que se presenta en forma de tumoraciones verrugosas. Aunque el tratamiento de elección sigue siendo motivo de controversia, el paciente presentado en este estudio fue tratado satisfactoriamente con itraconazol.

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