CuS nanoparticles anchored to g-C<sub>3</sub>N<sub>4</sub> nanosheets for photothermal ablation of bacteria

Liu, Xiaoyu; Li, Xiaoyan; Yan, Shan; Yin, Yuqing; Liu, Congrui; Lin, Ziyi; Kumar, Supriya Soraiya

doi:10.1039/d0ra00566e

Cited by 21 publications

(8 citation statements)

References 42 publications

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“…And the PXRD pattern of the NPs can be assigned to the crystal phase of CuS (JCPDS: 79-2321) (Figure S4). Energy dispersive spectroscopy of Cu 9 S 5 demonstrates distinguished signals of Cu, S, C, and O (Figure S5), which is consistent with the corresponding elemental mapping. Subsequently, the chemical states and composition of the as-synthesized Cu 9 S 5 NSs were explored by an X-ray photoelectron spectrometer.…”

Section: Resultssupporting

confidence: 82%

Ultrathin Cu₉S₅ Nanosheets with Sulfur Vacancy for Multimodal Tumor Therapy

Xu,

Liu,

Wei

et al. 2024

ACS Appl. Mater. Interfaces

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Multimodal tumor therapy with nanotechnology is an effective and integrative strategy to overcome the limitations of therapeutic efficacy and possible side effects associated with monotherapy. However, the construction of multimodal treatment nanoplatforms often involves various functional components, leading to certain challenges, such as time-consuming synthesis processes, low product yield, and inadequate biocompatibility. To address these issues, we have developed a straightforward method for preparing ultrathin Cu 9 S 5 nanosheets (NSs) with surface defects for photothermal/ photodynamic/chemodynamic therapy. The ultrathin morphology of the Cu 9 S 5 NSs (with 2−3 nm) not only confers excellent biocompatibility but also enables broad-spectrum absorption with a remarkable photothermal conversion efficiency (58.96%) under 1064 nm laser irradiation. Moreover, due to the presence of a S vacancy, these Cu 9 S 5 NSs exhibit favorable enzyme-like properties, including reactive oxygen species generation and glutathione consumption, particularly under laser irradiation. The efficacy of related tumor therapy and antibacterial treatment is significantly enhanced by the synergistic activation of photothermal/photodynamic/ chemodynamic therapy through 1064 nm laser irradiation, as demonstrated by both in vitro and in vivo experiments. This study presents a novel strategy for multimodal tumor therapy with the prepared ultrathin Cu 9 S 5 NSs, which holds promising pathways for photodynamic therapy in the NIR-II region.

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Section: Resultssupporting

confidence: 82%

Ultrathin Cu₉S₅ Nanosheets with Sulfur Vacancy for Multimodal Tumor Therapy

Xu,

Liu,

Wei

et al. 2024

ACS Appl. Mater. Interfaces

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“…During the PTT process, bacterial cell walls become wrinkled and damaged due to the high local temperature followed by the disruption of the cell membrane. Finally, the leakage of intracellular material leads to cell death [103,107,108].…”

Section: Synergistic Contribution Between Photothermal and Photodynamic Processesmentioning

confidence: 99%

Shining light on transition metal sulfides: New choices as highly efficient antibacterial agents

Han

Yang

et al. 2021

Nano Res.

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Globally, millions of people die of microbial infection-related diseases every year. The more terrible situation is that due to the overuse of antibiotics, especially in developing countries, people are struggling to fight with the bacteria variation. The emergence of super-bacteria will be an intractable environmental and health hazard in the future unless novel bactericidal weapons are mounted. Consequently, it is critical to develop viable antibacterial approaches to sustain the prosperous development of human society. Recent researches indicate that transition metal sulfides (TMSs) represent prominent bactericidal application potential owing to the meritorious antibacterial performance, acceptable biocompatibility, high solar energy utilization efficiency, and excellent photo-to-thermal conversion characteristics, and thus, a comprehensive review on the recent advances in this area would be beneficial for the future development. In this review article, we start with the antibacterial mechanisms of TMSs to provide a preliminary understanding. Thereafter, the state-of-the-art research progresses on the strategies for TMSs materials engineering so as to promote their antibacterial properties are systematically surveyed and summarized, followed by a summary of the practical application scenarios of TMSs-based antibacterial platforms. Finally, based on the thorough survey and analysis, we emphasize the challenges and future development trends in this area.

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“…45,46 The other peak observed around 48°corresponds to the (110) diffraction peak of CuS. 47 These results indicate that the structural phases of CuS nanocrystals are partially maintained even following the silica coating process. ζ-Potential analysis (Figure 2F) revealed that the ζ-potential of CuS nanoparticles was −10.4 ± 2.3 mV.…”

Section: Resultsmentioning

confidence: 86%

Sulfated Chitosan-Modified CuS Nanocluster: A Versatile Nanoformulation for Simultaneous Antibacterial and Bone Regenerative Therapy in Periodontitis

Chen,

Huang,

Wang

et al. 2024

ACS Nano

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Periodontitis, a prevalent chronic inflammatory disease worldwide, is triggered by periodontopathogenic bacteria, resulting in the progressive destruction of periodontal tissue, particularly the alveolar bone. To effectively address periodontitis, this study proposed a nanoformulation known as CuS@MSN-SCS. This formulation involves coating citrate-grafted copper sulfide (CuS) nanoparticles with mesoporous silica (MSNs), followed by surface modification using amino groups and sulfated chitosan (SCS) through electrostatic interactions. The objective of this formulation is to achieve efficient bacteria removal by inducing ROS signaling pathways mediated by Cu 2+ ions. Additionally, it aims to promote alveolar bone regeneration through Cu 2+ -induced pro-angiogenesis and SCS-mediated bone regeneration. As anticipated, by regulating the surface charges, the negatively charged CuS nanoparticles capped with sodium citrate were successfully coated with MSNs, and the subsequent introduction of amine groups using (3-aminopropyl)triethoxysilane was followed by the incorporation of SCS through electrostatic interactions, resulting in the formation of CuS@MSN-SCS. The developed nanoformulation was verified to not only significantly exacerbate the oxidative stress of Fusobacterium nucleatum, thereby suppressing bacteria growth and biofilm formation in vitro, but also effectively alleviate the inflammatory response and promote alveolar bone regeneration without evident biotoxicity in an in vivo rat periodontitis model. These findings contribute to the therapeutic effect on periodontitis. Overall, this study successfully developed a nanoformulation for combating bacteria and facilitating alveolar bone regeneration, demonstrating the promising potential for clinical treatment of periodontitis.

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CuS nanoparticles anchored to g-C₃N₄ nanosheets for photothermal ablation of bacteria

Abstract: CuS nanoparticles anchored to g-C3N4 nanosheets could be applied for photothermal ablation of bacteria.

Cited by 21 publications

References 42 publications

Ultrathin Cu₉S₅ Nanosheets with Sulfur Vacancy for Multimodal Tumor Therapy

Ultrathin Cu₉S₅ Nanosheets with Sulfur Vacancy for Multimodal Tumor Therapy

Shining light on transition metal sulfides: New choices as highly efficient antibacterial agents

Sulfated Chitosan-Modified CuS Nanocluster: A Versatile Nanoformulation for Simultaneous Antibacterial and Bone Regenerative Therapy in Periodontitis

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CuS nanoparticles anchored to g-C3N4 nanosheets for photothermal ablation of bacteria

Abstract: CuS nanoparticles anchored to g-C3N4 nanosheets could be applied for photothermal ablation of bacteria.

Cited by 21 publications

References 42 publications

Ultrathin Cu9S5 Nanosheets with Sulfur Vacancy for Multimodal Tumor Therapy

Ultrathin Cu9S5 Nanosheets with Sulfur Vacancy for Multimodal Tumor Therapy

Shining light on transition metal sulfides: New choices as highly efficient antibacterial agents

Sulfated Chitosan-Modified CuS Nanocluster: A Versatile Nanoformulation for Simultaneous Antibacterial and Bone Regenerative Therapy in Periodontitis

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Product

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CuS nanoparticles anchored to g-C₃N₄ nanosheets for photothermal ablation of bacteria

Ultrathin Cu₉S₅ Nanosheets with Sulfur Vacancy for Multimodal Tumor Therapy

Ultrathin Cu₉S₅ Nanosheets with Sulfur Vacancy for Multimodal Tumor Therapy