Current Zinc Intake and Risk of Diabetes and Coronary Artery Disease and Factors Associated with Insulin Resistance in Rural and Urban Populations of North India

Singh, Ram B.; Niaz, Mohammad A.; Rastogi, Shishir; Bajaj, Sarita; Zhang, Gaoli; Zhu, Shu

doi:10.1080/07315724.1998.10718804

Cited by 185 publications

(131 citation statements)

References 19 publications

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“…Low circulating zinc (in plasma or white blood cells) is common among hospitalized elderly patients and has been associated with many diseases including DM and AD (Walter et al 1991;Prasad et al 1993;Singh et al 1998;Pepersack et al 2001;Kazi et al 2008;Brewer et al 2010). However, in some cases (e.g.…”

Section: Risk Of Zinc Deficiency In the Elderlymentioning

confidence: 99%

“…For example, dietary zinc deficiency is known to decrease food intake in animal models and zinc supplementation improves taste acuity in elderly subjects (Pepersack et al 2001;Stewart-Knox et al 2008;Amani et al 2010). Inadequate zinc intake certainly contributes to deficiency in many elderly patients (Singh et al 1998;Pepersack et al 2001) but effects of chronic inflammation and age-related decline in zinc transport mechanisms may also contribute to a functional zinc deficiency (Turnlund et al 1986;Wong et al 2012). For example, senescence of rat vascular smooth muscle cells involves decreased ZnT expression (Patrushev et al 2012) and an age-related decline in plasma zinc was associated with increased methylation of the ZIP6 promoter and an exaggerated inflammatory response in mice (Wong et al 2012).…”

Section: Risk Of Zinc Deficiency In the Elderlymentioning

confidence: 99%

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Zinc and the aging brain

Nuttall

Oteiza

2013

Genes Nutr

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Alterations in trace element homeostasis could be involved in the pathology of dementia, and in particular of Alzheimer's disease (AD). Zinc is a structural or functional component of many proteins, being involved in numerous and relevant physiological functions. Zinc homeostasis is affected in the elderly, and current evidence points to alterations in the cellular and systemic distribution of zinc in AD. Although the association of zinc and other metals with AD pathology remains unclear, therapeutic approaches designed to restore trace element homeostasis are being tested in clinical trials. Not only could zinc supplementation potentially benefit individuals with AD, but zinc supplementation also improves glycemic control in the elderly suffering from diabetes mellitus. However, the findings that select genetic polymorphisms may alter an individual's zinc intake requirements should be taken into consideration when planning zinc supplementation. This review will focus on current knowledge regarding pathological and protective mechanisms involving brain zinc in AD to highlight areas where future research may enable development of new and improved therapies.

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Section: Risk Of Zinc Deficiency In the Elderlymentioning

confidence: 99%

Section: Risk Of Zinc Deficiency In the Elderlymentioning

confidence: 99%

Zinc and the aging brain

Nuttall

Oteiza

2013

Genes Nutr

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“…The first three nutrients ameliorate CVD risk, while iron may promote CVD progression. A study of 3,500 individuals established that those consuming <7 mg of dietary zinc/day were more likely to suffer from CAD, diabetes and glucose intolerance [52]. There was a higher incidence of hypertension, high plasma TAG, and lower plasma HDL in the group.…”

Section: Other Meat Nutrients As Risk Factors For Cvdmentioning

confidence: 99%

Role of animal meats in cardiovascular diseases with reference to Sub-Saharan Africa: A review

Lokuruka¹

2010

African Journal of Food, Agriculture, Nutrition and Development

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Although animal food products are important sources of dietary protein in the diets of many African communities, questions are being raised concerning the role of animal meats and other animal products in chronic diseases including cardiovascular diseases. This review of the literature was, therefore, conducted to provide information on the role of animal meats and their nutrients in cardiovascular diseases, with reference to sub-Saharan Africa. In sub-Saharan Africa, infectious diseases are the current commonest cause of death, but cardiovascular diseases are set to surpass them as the major cause of mortality and morbidity. Although rare in the past, there are indications that coronary heart disease will become a burden to the health care system in sub-Saharan Africa. Diet is an important part of the control and management of cardiovascular diseases as most risk factors including diabetes mellitus, obesity, low-density lipoprotein and triacylglycerol levels, alcohol and blood pressure are all connected to diet. Animal meats can be significant sources of dietary saturated fatty acids and cholesterol due to their considerable lipid content. Dietary saturated fatty acids and cholesterol are significant influences on the development and progression of atherosclerosis, a major type of cardiovascular disease. Heart disease and high serum cholesterol also increase the risk of stroke. Although dietary protein is considered to be of minor importance in the aetiology of cardiovascular disease, epidemiological studies have shown the consumption of animal protein to be positively correlated with cardiovascular disease incidence, while that of vegetable protein is negatively correlated with cardiovascular disease mortality rates. Also, due to the higher content of cholesterol in organ meats compared to skeletal muscles, it is recommended that their dietary consumption be limited. It, therefore, seems beneficial to reduce the dietary intake of saturated fatty acids and cholesterol from meats and other high-fat, high-cholesterol animal foods, except fatty fish, since it is established on the basis of documented scientific evidence that reduction in serum cholesterol results in reduction of coronary morbidity and mortality. This review, therefore, recommends reduction in the intake of fatty red animal meat, while promoting consumption of portion-controlled lean white meats such as poultry, wild game and fatty fish. This can be achieved by integrating these recommendations into food and nutritional policy practice in Africa.

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“…Dietary Zn deficiency causes increased susceptibility to oxidative damage of membrane fractions from some tissues. Thus, increased oxidative stress may be a small, but significant, component of pathologies observed in elderly, in particular, cardiovascular diseases (Singh et al, 1998). At least two mechanisms have been elucidated: the protection of sulphhydryl groups against oxidation, and the inhibition of the production of reactive oxygen by transition metals (Bettger, 1993).…”

Section: Zn and Oxidative Stressmentioning

confidence: 99%

Importance of zinc in the elderly: the ZENITH study

Meunier

O’Connor

Maiani³

et al. 2005

Eur J Clin Nutr

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The elderly are at nutritional risk as a result of multiple physiological, social, psychological, and economic factors. Physiological functions naturally decline with age, which may influence absorption and metabolism. Social and economic conditions can adversely affect dietary choices and eating patterns. However, at the same time, the nutrient needs of the elderly for certain nutrient (such as vitamins, minerals, proteins) is higher than for younger adults. This article reviews the importance of zinc (Zn) in elderly people, particularly for behavioural and mental function, micronutrient status, immune and antioxidant system, and bone metabolism.

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Current Zinc Intake and Risk of Diabetes and Coronary Artery Disease and Factors Associated with Insulin Resistance in Rural and Urban Populations of North India

Abstract: Lower consumption of dietary zinc and low serum zinc levels were associated with an increased prevalence of CAD and diabetes and several of their associated risk factors including hypertension, hypertriglyceridemia and other factors suggestive of mild insulin resistance in urban subjects.

Cited by 185 publications

References 19 publications

Zinc and the aging brain

Zinc and the aging brain

Role of animal meats in cardiovascular diseases with reference to Sub-Saharan Africa: A review

Importance of zinc in the elderly: the ZENITH study

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