Current views in chronic obstructive pulmonary disease pathogenesis and management

Alfahad, Ahmed J.; Alzaydi, Mai M.; Aldossary, Ahmad M.; Alshehri, Abdullah A.; Almughem, Fahad A.; Zaidan, Nada; Tawfik, Essam A.

doi:10.1016/j.jsps.2021.10.008

Cited by 25 publications

(17 citation statements)

References 164 publications

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“…The former leads to airway wall thickness, mucus hypersecretion, and narrowed bronchioles, while the latter induces the destruction of alveoli structure. [ 36 ] Herein, we observed that a higher portion of COVID-19 patients with COPD presented with dyspnea at disease onset compared with their non-COPD counterparts. One reason is that a small proportion of the 78 COPD patients were at acute attack phase.…”

Section: Discussionmentioning

confidence: 80%

Clinical course and outcomes of COVID-19 patients with chronic obstructive pulmonary disease

et al. 2022

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Information about coronavirus disease 2019 (COVID-19) patients with pre-existing chronic obstructive pulmonary disease (COPD) is still lacking. The aim of this study is to describe the clinical course and the outcome of COVID-19 patients with comorbid COPD.This retrospective study was performed at Wuhan Huoshenshan Hospital in China. Patients with a clear diagnosis of COVID-19 who had comorbid COPD (N = 78) were identified. COVID-19 patients without COPD were randomly selected and matched by age and sex to those with COPD. Clinical data were analyzed and compared between the two groups. The composite outcome was the onset of intensive care unit admission, use of mechanical ventilation, or death during hospitalization. Multivariable Cox regression analyses controlling for comorbidities were performed to explore the relationship between comorbid COPD and clinical outcome of COVID-19.Compared to age-and sex-matched COVID-19 patients without pre-existing COPD, patients with pre-existing COPD were more likely to present with dyspnea, necessitate expectorants, sedatives, and mechanical ventilation, suggesting the existence of acute exacerbations of COPD (AECOPD). Greater proportions of patients with COPD developed respiratory failure and yielded poor clinical outcomes. However, laboratory tests did not show severer infection, over-activated inflammatory responses, and multiorgan injury in patients with COPD. Kaplan-Meier analyses showed patients with COPD exhibited longer viral clearance time in the respiratory tract. Multifactor regression analysis showed COPD was independently correlated with poor clinical outcomes.COVID-19 patients with pre-existing COPD are more vulnerable to AECOPD and subsequent respiratory failure, which is the main culprit for unfavorable clinical outcomes. However, COPD pathophysiology itself is not associated with over-activated inflammation status seen in severe COVID-19. Abbreviations: ACE2 = angiotensin-converting enzyme 2, AECOPD = acute exacerbations of COPD, AKI = acute kidney injury, ALT = alanine transaminase, ARDS = acute respiratory distress syndrome, AST = aspartate aminotransferase, BNP = brain natriuretic peptide, CHD = coronary heart disease, COPD = chronic obstructive pulmonary disease, COVID-19 = Coronavirus disease 2019, CT = computerized tomography, cTnI = cardiac troponin I, DIC = disseminated intravascular coagulation, ICU = intensive care unit, MODS = multiple organ dysfunction syndrome, SARS-CoV-2 = severe acute respiratory syndromecoronavirus-2, SIC = sepsis-induced coagulopathy; TBIL = total bilirubin, ULN = upper limit unit.

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Section: Discussionmentioning

confidence: 80%

Clinical course and outcomes of COVID-19 patients with chronic obstructive pulmonary disease

et al. 2022

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“…COPD often occurs due to chronic exposure to irritants, specifically in the lungs and airways. Cigarette smoke (CS) is recognized as an important risk factor in the development of COPD [5,7,14]. Exposure to CS or nicotine causes, exacerbates, and prolongs the symptoms and features of COPD and associated PH, where up to 90% of COPD cases can be attributed to cigarette or e-cigarette smoke [15][16][17][18].…”

Section: Causes and Risk Factorsmentioning

confidence: 99%

The Potential Important Role of Mitochondrial Rieske Iron–Sulfur Protein as a Novel Therapeutic Target for Pulmonary Hypertension in Chronic Obstructive Pulmonary Disease

2022

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Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide, which is often due to pulmonary hypertension (PH). The underlying molecular mechanisms are poorly understood, and current medications are neither specific nor always effective. In this review, we highlight the recent findings on the roles of altered mitochondrial bioenergetics in PH in COPD. We also discuss the central role of mitochondrial reactive oxygen species (ROS) generation mediated by Rieske iron–sulfur protein (RISP) and review the contributions of RISP-dependent DNA damage and NF-κB-associated inflammatory signaling. Finally, the potential importance of mitochondrial RISP and its associated molecules as novel therapeutic targets for PH in COPD are meticulously discussed.

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“…Extracellular vesicles (EVs) are membranous structures containing many biomolecules that are released from a variety of biological fluids and can be transferred from their source cells to recipient cells; thus, EVs play an essential role in cargo transfer and intracellular communication and participate in physiology and pathology [1]. According to the Minimal Information for Studies of Extracellular Vesicles 2018 (MISEV2018) held by the International Society for Extracellular Vesicles (ISEV), EVs include exosomes and microvesicles.…”

Section: Introductionmentioning

confidence: 99%

“…Yaojie Wang, Ying Zhang and Zhi Li are contributed equally to this manuscript. thus, EVs play an essential role in cargo transfer and intracellular communication and participate in physiology and pathology [1]. According to the Minimal Information for Studies of Extracellular Vesicles 2018 (MISEV2018) held by the International Society for Extracellular Vesicles (ISEV), EVs include exosomes and microvesicles.…”

Section: Introductionmentioning

confidence: 99%

Combination of size‐exclusion chromatography and ion exchange adsorption for improving the proteomic analysis of plasma‐derived extracellular vesicles

Wang

Zhang

et al. 2023

Proteomics

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Extracellular vesicles (EVs) are lipid membrane vesicles released by live cells that carry a variety of biomolecules, including nucleic acids, lipids, and proteins. Recently, proteins in plasma-derived EVs have emerged as novel biomarkers with essential functions in the diagnosis and prognosis of human diseases. However, the current methods of isolating EVs from plasma often lead to coisolated impurities in biological fluids.Therefore, before performing any research protocol, the process of extracting EVs from plasma for proteomic analysis must be optimized. In this study, two EV isolation strategies, size exclusion chromatography (SEC) and SEC combined with ion exchange adsorption (SEC + IEA), were compared in terms of the purity and quantity of protein in EVs. Our results demonstrated that, compared to single-step SEC, SEC combined with IEA could produce plasma-derived EVs with a higher purity by decreasing the abundance of lipoprotein. Additionally, with MS analysis, we demonstrated that the combination approach maintained the stability and improved the purity of EVs in many plasma samples. Furthermore, by combining SEC with IEA, more cancer-associated proteins were detected in the plasma of various cancer samples.

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Current views in chronic obstructive pulmonary disease pathogenesis and management

Cited by 25 publications

References 164 publications

Clinical course and outcomes of COVID-19 patients with chronic obstructive pulmonary disease

Clinical course and outcomes of COVID-19 patients with chronic obstructive pulmonary disease

The Potential Important Role of Mitochondrial Rieske Iron–Sulfur Protein as a Novel Therapeutic Target for Pulmonary Hypertension in Chronic Obstructive Pulmonary Disease

Combination of size‐exclusion chromatography and ion exchange adsorption for improving the proteomic analysis of plasma‐derived extracellular vesicles

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