Current Use of Probiotics and Prebiotics in Allergy

Fiocchi, Alessandro; Cabana, Michael D.; Mennini, Maurizio

doi:10.1016/j.jaip.2022.06.038

Cited by 36 publications

(23 citation statements)

References 141 publications

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“…However, viral confirmation is not usually conducted for routine URIs, and the finding of fever is not typically seen with allergic symptoms. Furthermore, although there have been some prior studies to suggest probiotics may decrease symptoms of atopic diseases, 19 there were no overlapping effects in our study. An additional limitation of our study is that we do not have data regarding the number or duration of hospitalizations that may have occurred due to these viral respiratory infections.…”

Section: Discussioncontrasting

confidence: 55%

Effect of Early Infant Lactobacillus rhamnosus GG Supplementation in Preventing Viral Respiratory Illness

Conrad

LeCroy

Rothschild

et al. 2022

Clin Pediatr (Phila)

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The role of early probiotic supplementation in infants for the prevention of respiratory viral illnesses is unclear. We examined the association of Lactobacillus rhamnosus GG (LGG) supplementation during the first 6 months of life with the frequency and severity of viral illnesses during the first 24 months of life. We conducted a secondary analysis of data from the randomized controlled Trial of Infant Probiotic Supplementation ( n = 184). Parents reported the number of respiratory viral illnesses, and a composite severity score was created based on symptoms. A negative binomial regression model and a mixed-effects linear regression model assessed for differences in the number of episodes and severity of episodes between treatment groups, respectively. There was no significant difference in the incidence rate of viral illness episodes or symptom severity between treatment groups. Daily supplementation with LGG in early infancy does not decrease the number or severity of viral illnesses during the first 2 years of life.

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Section: Discussioncontrasting

confidence: 55%

Effect of Early Infant Lactobacillus rhamnosus GG Supplementation in Preventing Viral Respiratory Illness

Conrad

LeCroy

Rothschild

et al. 2022

Clin Pediatr (Phila)

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“…This notion is corroborated by the finding that probiotic intervention showed a protective effect on atopic eczema. This result, published from the three original studies, 16–18 has since been repeated in several clinical probiotic trials 28 …”

Section: Discussionmentioning

confidence: 69%

“…This result, published from the three original studies, [16][17][18] has since been repeated in several clinical probiotic trials. 28 When assessing the allergy risk factors, not all hypotheses can be evaluated by intervention studies for ethical reasons, whereas, a case-control study is a safe method for epidemiological research.…”

Section: F I G U R E 1 Allergic Manifestations In Childrenmentioning

confidence: 99%

Early life exposures and development of allergic disease in infants with familial risk: Results from ongoing probiotic intervention trials

et al. 2022

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Aim We search revision of risk determinants of the ongoing allergy epidemic. Methods Children numbering 433 born to mothers with allergic disease or sensitisation were selected from the three ongoing probiotic intervention trials for this case–control study. Children who developed atopic eczema or food allergy, had positive skinprick test results or had been prescribed inhaled corticosteroids by the age of 2 years were identified as cases (n = 231), while children without allergic manifestations were the healthy controls (n = 202). The data on early environmental exposures were collected from prospectively documented study records. The statistical analyses were adjusted for potential confounders. Results Determinants associated with the increased risk of atopic eczema were lower maternal prepregnancy BMI (aOR 0.15, 95% CI: 0.037–0.54) and maternal intrapartum antibiotic treatment (aOR 2.21, 95% CI 1.20–4.10), the latter also linked to obstructive respiratory symptoms (aOR 3.87, 95% CI 1.07–14.06). The risk of allergic sensitisation was associated with lower maternal prepegnancy BMI (aOR 0.18, 95% CI 0.43–0.79) and intrapartum antibiotic treatment (aOR 2.13, 95% CI 1.07–4.22). Conclusion Based on our demonstrations, interventions such as personalised diets, can be optimised for specific subgroups and definite risk periods.

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“…The mixture of strains Bifidobacterium animalis subsp lactis CECT 8145, Bifidobacterium longum CECT 7347, and Lactobacillus casei CECT 9104 was associated with the best results in the pediatric population, and the mixture of Lactobacillus salivarius LS01 and Bifidobacterium breve BR03 has the best results in adults [ 158 , 159 , 160 ]. Similar to AD, some probiotics may be effective in the prevention and treatment of allergies [ 161 , 162 ].…”

Section: Future Perspectivesmentioning

confidence: 99%

Bacterial Metabolites: A Link between Gut Microbiota and Dermatological Diseases

Stec

Sikora

Maciejewska

et al. 2023

IJMS

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Dysbiosis has been identified in many dermatological conditions (e.g., psoriasis, atopic dermatitis, systemic lupus erythematosus). One of the ways by which the microbiota affect homeostasis is through microbiota-derived molecules (metabolites). There are three main groups of metabolites: short-chain fatty acids (SCFAs), tryptophan metabolites, and amine derivatives including trimethylamine N-oxide (TMAO). Each group has its own uptake and specific receptors through which these metabolites can exert their systemic function. This review provides up-to-date knowledge about the impact that these groups of gut microbiota metabolites may have in dermatological conditions. Special attention is paid to the effect of microbial metabolites on the immune system, including changes in the profile of the immune cells and cytokine disbalance, which are characteristic of several dermatological diseases, especially psoriasis and atopic dermatitis. Targeting the production of microbiota metabolites may serve as a novel therapeutic approach in several immune-mediated dermatological diseases.

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Current Use of Probiotics and Prebiotics in Allergy

Cited by 36 publications

References 141 publications

Effect of Early Infant Lactobacillus rhamnosus GG Supplementation in Preventing Viral Respiratory Illness

Effect of Early Infant Lactobacillus rhamnosus GG Supplementation in Preventing Viral Respiratory Illness

Early life exposures and development of allergic disease in infants with familial risk: Results from ongoing probiotic intervention trials

Bacterial Metabolites: A Link between Gut Microbiota and Dermatological Diseases

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