Current Understanding of Virus Etiology in Leukemia

Hehlmann, Rüdiger; Schetters, H.; Leib-Mösch, Christine; Erfle, Volker

doi:10.1007/978-3-642-82249-0_1

Cited by 2 publications

(2 citation statements)

References 162 publications

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“…A comparison should be made between the retrovirusrelated human placental p30 protein and the predicted protein product of the human endogenous retrovirus p30 gag gene (14,15), the SSAV p28 cross-reactive protein found in some patients with leukemia (35,45,46) or system lupus erythematosus (27,34,43), and the p24 core protein of the exogenous human T-cell leukemia virus (44).…”

Section: Discussionmentioning

confidence: 99%

“…The antibody dilution titers of antiretrovirus p30 serums were determined by indirect enzymoimmunoassay as described (34). Competition enzymoimmunoassays were developed as described (35) for SSAV/GaLV p28 by using GaLV target and goat IgG anti-SSAV p28 and for BEV/RD-114 p28 by using BEV target and goat IgG anti-RD-114 p28. 1-4), anti-RD-114 p28 serum (lanes 5-7), and normal goat serum (lanes 8-10) against 50 ng of SSAV (lanes 1,6, and 8), 50 ng of GaLV (lane 2), 50 ng of RD-114 (lanes 3, 5, and 9), and 200 ng of MuLV (lanes 4, 7, and 10).…”

Section: Methodsmentioning

confidence: 99%

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Detection and immunochemical characterization of a primate type C retrovirus-related p30 protein in normal human placentas.

Jerabek¹,

Mellors²,

Elkon³

et al. 1984

Proc. Natl. Acad. Sci. U.S.A.

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We find that 12 of 14 specimens of normal human term placentas analyzed by one-or two-dimensional electrophoresis and immunoblotting contain a protein or polypeptide of -30,000 daltons that is antigenically cross-reactive with p30 core protein of the simian sarcoma-associated virus/gibbon ape leukemia virus primate retrovirus group and is physicochemically similar to reference murine and primate type C retrovirus p30s. This finding may lead to an understanding of endogenous type C retrovirus gene expression in humans.Endogenous type C retroviruses are present in many mammalian species, including subhuman primates (1-4) among which the baboon (1, 5) has the closest evolutionary relation to man. These endogenous viruses exist as stable DNA proviruses that are integrated into the chromosomal DNA and are transmitted along with cellular genes in a Mendelian manner.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Detection and immunochemical characterization of a primate type C retrovirus-related p30 protein in normal human placentas.

Jerabek¹,

Mellors²,

Elkon³

et al. 1984

Proc. Natl. Acad. Sci. U.S.A.

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Comparative research on leukemia and related diseases: An introduction to a scientific approach

Hehlmann

Essex

1997

Journal of Molecular Medicine

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Publication in this journal of the abstracts of the Nineteenth Symposium of the International Association for Comparative Research on Leukemia and Related Diseases in Mannheim/Heidelberg led editor and publisher to suggest an article introducing comparative research in leukemia and related diseases. Our survey briefly summarizes the history of this symposium, as it evolved from a meeting on animal leukemia virus into one dealing with viral and genetic aspects of human and animal leukemia and related diseases. The scientific evolution of the Abelson murine leukemia virus with its abl oncogene in the 1970s to what currently appears as the most reliable marker for human chronic myeloid leukemia is merely one example.

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Current Understanding of Virus Etiology in Leukemia

Cited by 2 publications

References 162 publications

Detection and immunochemical characterization of a primate type C retrovirus-related p30 protein in normal human placentas.

Detection and immunochemical characterization of a primate type C retrovirus-related p30 protein in normal human placentas.

Comparative research on leukemia and related diseases: An introduction to a scientific approach

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