Current Trends of Treatment

Maximum androgen blockade: a case study report

“…There is extensive evidence to suggest that¯are protection should be used in all metastatic prostate cancer patients when beginning LHRHa therapy. 37,38 Case six. Case six is a 62-y-old man, otherwise healthy, who was referred with lower urinary tract symptoms (LUTS) which had increased in severity during the last 6 months.…”

Recent Advances in the Medical Management of Prostate Cancer

“…Huggins and Scott recognised the transient nature of the response obtained with testicular androgen ablation as long ago as 1945, and attempted to treat relapsing patients by bilateral adrenalectomy 27 . Later, attempts were made with aminoglutethimide and high‐dose ketoconazole, but neither drug is currently in widespread use in this indication 28 . Removing the stimulus of androgens of both testicular and adrenal origin can now be achieved with the use of anti‐androgens that antagonise the action of androgens at the nuclear receptor (Figure 1).…”

“…Advances in screening and early detection are also pointing to the need for studies designed to determine the best time for starting treatment, and the subsequent treat-REVIEW ment intervals, in patients with advanced disease. The question of treatment timing is currently under investigation in two trials conducted by the EORTC 28 and one by the Medical Research Council. 56 Intermittent treatment of prostate cancer is an interesting concept that may have benefits in terms of improved survival, reduced costs, improved quality of life, and recovery of sexual function.…”