2018
DOI: 10.1001/jamafacial.2017.1567
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Current Trends in Management of Submental Liposis

Abstract: IMPORTANCE Since its approval by the US Food and Drug Administration for treatment of moderate to severe submental liposis in April 2015, deoxycholic acid (Kybella) has received significant media attention as a novel aesthetic treatment. Four phase 3 clinical trials have published data demonstrating the safety and efficacy of the drug compared with placebo; however, no study has juxtaposed the product with submental liposuction. OBJECTIVE To evaluate the efficacy of injectable deoxycholic acid in the treatment… Show more

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Cited by 9 publications
(4 citation statements)
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“…Although multiple clinical trials have been conducted, a pooled analysis showed that 70.2% of patients experience >1-point improvement in the 5-point clinician-reported submental fat rating scale after a mean of 4.1 treatments. 37 The most common side effects are minor and include pain, bruising, edema, and numbness; however, transient marginal mandibular nerve weakness has been reported as high as 4.3%. 38 In addition, in a survey of members of the Academy of Facial Plastic and Reconstructive Surgery, the average cost of a complete treatment of submental fat using deoxycholic acid was US$6426.35, compared with traditional submental liposuction which would cost an average of US$2976.56.…”
Section: Discussionmentioning
confidence: 99%
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“…Although multiple clinical trials have been conducted, a pooled analysis showed that 70.2% of patients experience >1-point improvement in the 5-point clinician-reported submental fat rating scale after a mean of 4.1 treatments. 37 The most common side effects are minor and include pain, bruising, edema, and numbness; however, transient marginal mandibular nerve weakness has been reported as high as 4.3%. 38 In addition, in a survey of members of the Academy of Facial Plastic and Reconstructive Surgery, the average cost of a complete treatment of submental fat using deoxycholic acid was US$6426.35, compared with traditional submental liposuction which would cost an average of US$2976.56.…”
Section: Discussionmentioning
confidence: 99%
“…38 In addition, in a survey of members of the Academy of Facial Plastic and Reconstructive Surgery, the average cost of a complete treatment of submental fat using deoxycholic acid was US$6426.35, compared with traditional submental liposuction which would cost an average of US$2976.56. 37…”
Section: Discussionmentioning
confidence: 99%
“…Due to these characteristics, it is used in mesotherapy injections to produce lipolysis and has been used as an alternative to surgical excision of adipose tissue. It has been approved by the Food and Drug Administration (FDA) for the reduction of submental fullness [9].…”
Section: Introductionmentioning
confidence: 99%
“…Treatment resolution improves the adjacent tissues' apposition, reduces the risk of ventilatory complications, and refines skin color. 6,10,11…”
Section: Introductionmentioning
confidence: 99%