Background: Double chin treatment options often encompass a blend of exercises and mesotherapy. This study aimed to assess treatment of double chin with exercises and mesotherapy. Methods: Thirty female patients, aged 22 to 55 years (mean age: 44.5 years ± 5.6 SD), were treated with a cocktail comprising Phosphatidyle choline, 20% Caffeine, and 0.5% organic Silicium. The treatment protocol involved up to six sessions spaced a week apart, injecting 0.3 ml of the cocktail per site using a pointby-point technique. Post-injection, patients received instructions for home care and were prescribed daily double chin reduction exercises. The evaluation encompassed physician assessments through blinded photograph evaluation, patient self-assessment questionnaires, and monitoring of adverse effects. Results: Among 30 female participants (mean age 44.5 ± 5.6 years) with moderate to significant sub-mental fat deposits, 90% reported improvement post-treatment. Specifically, 16.7% experienced moderate improvement, while 26.7% reported significant and very significant improvements each. Rater agreement in assessing patient improvement was substantial (k=0.84). Adverse events included edema (23.3%), pain (23.3%), erythema (16.7%) resolving within two weeks, and subcutaneous nodules in 2 patients. Conclusions: The combination therapy demonstrated a high rate of patient-perceived improvement in double chin reduction. Clinician assessments aligned with patient-reported outcomes, affirming the treatment's efficacy. Adverse events, while present, were mostly transient and manageable.