Background: During COVID-19, academic nursing students face many challenges as a result of online learning. During the COVID-19 pandemic, the greatest disruption of learning in history and had a global impact on learners and teachers. The study aimed to recognize perception, satisfaction, and obstacle of online learning faced by academic nursing students during COVID-19 pandemic. Subjects and Methods: Design: A descriptive research design was used in this study. Setting: The study was applied in the Faculty of Nursing, Sohag University. Sample: A convenient sample of 230 including all the third academic nursing students' years in the previously mentioned setting. Four tools of data collection: (I) an online questionnaire was used. It consisted of two parts; (1) demographic characteristics of academic nursing students, (2) educational platforms were used, (II) online learning obstacles faced by academic students, (III) learner satisfaction with online learning, (IV) students' perception toward online learning assessment sheet. Results: The revealed that the most used platform among academic nursing students was the Microsoft platform for online learning. The most obstacles faced by the students during online learning concern the Learners' characteristics dimension, as well as less than two-thirds of the studied academic nursing students, face a high level of obstacles. Also, about two-thirds of students were unsatisfied with their online learning experience. There is a positive statistically significant correlation between total perception and obstacles for online learning. Conclusion: It was found that academic nursing students were unsatisfied with continuing online learning during COVID-19 and faced many obstacles that interfere with their education. Recommendations: Educating the younger generation of academic nursing students about how to use online learning platforms to transform them into the future through various media and faculties to help academic them become more knowledgeable and skilled