Current trends and hotspots in drug-resistant epilepsy research: Insights from a bibliometric analysis

Abstract

BackgroundDrug-resistance is a significant clinical issue in persons with epilepsy. In the past few years, many studies have been published investigating the management of drug-resistant epilepsy (DRE); however, no systematic and quantitative evaluation of this research has been performed. Therefore, a bibliometric analysis was conducted to demonstrate the current status of DRE research and to reflect the trends and hotspots within the field.MethodsWe retrieved publications on DRE published between 2011 and 2021 from the Science Citation Index Expanded of the Web of Science Core Collection. All articles related to DRE were included in this study. VOSviewer, R software, and CiteSpace were used to perform bibliometric research.ResultsA total of 3,088 original articles were included in this study. The number of publications on DRE has continued to increase over the past 11 years. The USA published the most papers with the highest number of citations and H-index. The National Institutes of Health and the University of Toronto were the most prolific funding agency and affiliation, respectively. Epilepsy & Behavior and Epilepsia ranked first as the most prolific and co-cited journals, respectively. The keywords “cannabidiol”, “neuromodulation”, “seeg” and “perampanel” revealed recent research hotspots. The top 100 most cited papers were classified into eight main topics, of which pharmacotherapy, disease mechanisms/pathophysiology, and neuromodulation were the three most important topics.ConclusionsThis analysis of bibliometric data demonstrated that DRE has always been a topical area of research. The mechanisms of epilepsy and therapies have been the focus of DRE research, and innovative antiseizure medications and surgical approaches are fast-developing research trends.

Tracing topics and trends in drug‐resistant epilepsy research using a natural language processing–based topic modeling approach

“…The recent bibliometric analysis by Ni et al. provided a broad overview of DRE research, but limitations existed compared to our current study 54 . Unlike our study, their analysis did not leverage NLP for topic modeling.…”

“…The recent bibliometric analysis by Ni et al provided a broad overview of DRE research, but limitations existed compared to our current study. 54 Unlike our study, their analysis did not leverage NLP for topic modeling. Instead, they manually categorized only the top 100 highly cited articles into eight topics, whereas our NLP approach automatically classified all 11 743 documents into 18 distinct topics.…”

Top 100 cited research on COVID-19 vaccines: A bibliometric analysis and evidence mapping

“…Journal impact factors (IF) and journal category quartiles (Q) are from the 2022 Journal Citation Report (JCR). 20 In addition, it is used to construct evidence maps and this study is presented in the form of bubble charts, pie charts, and histograms. 21 We use VOSviewer1.6.18 (Van Eck and Waltman, Leiden University, Netherlands) for bibliometric analysis and mapping processes, and to construct and visualize bibliometric networks.…”

“… 25 In the visual network diagram generated by VOSviewer1.6.18, each node represents a different element (author, country, organization, and keyword), the size of the node represents the frequency of occurrence of the element or the number of publications, the lines between the nodes represents cooperative or co-occurrence relationships, and the thickness of the lines between the nodes indicates the degree of connection. 16 , 20 , 26 The node colors indicate different clusters.…”

Bibliometric Analysis of the Published Studies on the Kindling Model between 1980 and 2023

“…Bibliometric analysis is the quantitative analysis of publications to better understand research outputs using mathematical and statistical methods (10). Bibliometric data analysis sets provide important data on determining the scientific effect and course of research through performance analyses and bibliometric networks (11). Examinations made through online databases provide a great convenience for us to see the current state of academic studies, their scientific volumes, and their effects, including citations (12).…”