Current trend in antimicrobial susceptibility pattern of &lt;i&gt;Clostridium tetani&lt;/i&gt; isolated from soil samples in Kano

Bukar, A.; Mukhtar,; Adam, S.E.I.

doi:10.4314/bajopas.v1i1.57539

Cited by 3 publications

(4 citation statements)

References 2 publications

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“…However, 100% failed with 17-20 mm against C. tetani when isolated from soil. This does not agree with the data of Bukar et al [9], who reported a value of 26 mm for C. tetani.…”

Section: Discussioncontrasting

confidence: 99%

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Evaluating the Potency of Selected Antibiotic Medications Dispensed in Community Pharmacies in Gwale, Kano, Nigeria

Mukhtar,

Rufa’i,

Yola

et al. 2023

Antibiotics

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The worsening of antibiotic resistance is a multifactorial process. One aspect of this is the counterfeiting of antibiotic medications. This is supposed to be particularly high in developing countries, including Nigeria. Therefore, the potency of some antibiotic drugs dispensed in community pharmacies in Gwale, Kano, Nigeria, was investigated in this case study. Three products, each from different manufacturers, with the active ingredients of ceftriaxone, gentamicin, ciprofloxacin, and metronidazole, respectively, were included in this study. By means of a disc-diffusion assay, the effect against the typed strains Staphylococcus aureus (ATCC 25923) and Escherichia coli (ATCC 25922) as well as Clostridium tetani isolated from soil was tested. Clinical isolates of S. aureus and E. coli were also used. While antibiotics, with the exception of ciprofloxacin-containing preparations against C. tetani, showed acceptable efficacy against the typed strains by comparison with the clinical science laboratory references, a predominant failure was observed with the clinical isolates. Thus, the investigated drug preparations can be considered of acceptable quality for the treatment of susceptible bacterial infections. This excludes counterfeits in the sampled preparations. However, the insufficient efficacy against clinical isolates further documents the severity of nosocomial bacteria.

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“…However, 100% failed with 17-20 mm against C. tetani when isolated from soil. This does not agree with the data of Bukar et al [9], who reported a value of 26 mm for C. tetani.…”

Section: Discussioncontrasting

confidence: 99%

“…At the international level, the present results are also comparable with the reports of Gashe et al [11] from Ethiopia and Wu et al [12] from China. The full activity of metronidazole-containing preparations against C. tetani in wild soil is also consistent with reports from a study by Bukar et al [9].…”

Section: Discussionsupporting

confidence: 91%

Evaluating the Potency of Selected Antibiotic Medications Dispensed in Community Pharmacies in Gwale, Kano, Nigeria

Mukhtar,

Rufa’i,

Yola

et al. 2023

Antibiotics

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“…The collected samples were stored in sterile plastic tubes and frozen at −70 °C within 6 to 12 h for later analysis [16,17,18,19].…”

Section: Methodsmentioning

confidence: 99%

The First Identification and Antibiogram of Clostridium perfringens Type C Isolated from Soil and The Feces of Dead Foals in South Korea

Park

Hwang

Cho

2019

Animals

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Clostridium (C.) perfringens was isolated from 25 (11.1%) of 225 sampled horses and from 16 (35.56%) of 45 farms. All of the samples were negative for cpe, etx, itx, NetF genes and cpa gene were detected in 100% (25 of 25) of the samples that were positive for C. perfringens. cpb and cpb2 were detected in 40.0% (10 of 25) and 60.0% (15 of 25) of the samples that were positive for C. perfringens, respectively. Of the 25 C. perfringens isolates, 15 (60%) were type A and 10 (40%) were type C. Type C was observed on all the farms where the foals’ deaths occurred. None of the isolates were positive for type B, type D, or type E. The MIC Evaluator strips antimicrobial susceptibility test showed meropenem (96%), ampicillin (92%), amoxicillin/clavulanic acid (84%), and tetracycline (8%) sensitivity.

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“…Previously, the isolation of the C. tetani from the different soil samples was carried out by Bukar and his colleagues using an anaerobic culturing technique. 25 In this study, the isolation of the clinical bacterial isolates of C. tetani was performed from clinically diagnosed tetanus patients. 26 As a site of infection was obvious in our patients, this increased the isolation rate of C. tetani by inoculating the primary media with C. tetani isolates.…”

Section: Discussionmentioning

confidence: 99%

Isolation and Antibiogram of Clostridium tetani from Clinically Diagnosed Tetanus Patients

Hanif¹,

Anjum²,

Ali³

et al. 2015

The American Society of Tropical Medicine and Hygiene

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Abstract. Clostridium tetani, the etiologic agent of tetanus, produces a toxin that causes spastic paralysis in humans and other vertebrates. This study was aimed for isolation, identification, and determination of antimicrobial susceptibility of C. tetani from clinically diagnosed tetanus patients. Isolation was done from deep-punctured tissues of the foot and arm injuries of 80 clinically diagnosed tetanus patients from the Pakistan Institute of Medical Sciences hospital. We successfully screened out five C. tetani isolates out of 80 samples based on the strain-specific characteristics confirmed through biochemical testing and toxin production. A disc diffusion method was used for antimicrobial susceptibilities and C. tetani isolates showed susceptibility to cefoperazone, chloramphenicol, metronidazole, penicillin G, and tetracycline, but were found to be resistant to erythromycin and ofloxacin. During animal testing, all the infected mice developed symptoms of tetanus. The results showed that identification of C. tetani is possible using biochemical and molecular tools and that the strains of C. tetani isolated had not developed resistance against the antibiotics most often used for the treatment of tetanus.

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Current trend in antimicrobial susceptibility pattern of <i>Clostridium tetani</i> isolated from soil samples in Kano

Cited by 3 publications

References 2 publications

Evaluating the Potency of Selected Antibiotic Medications Dispensed in Community Pharmacies in Gwale, Kano, Nigeria

Evaluating the Potency of Selected Antibiotic Medications Dispensed in Community Pharmacies in Gwale, Kano, Nigeria

The First Identification and Antibiogram of Clostridium perfringens Type C Isolated from Soil and The Feces of Dead Foals in South Korea

Isolation and Antibiogram of Clostridium tetani from Clinically Diagnosed Tetanus Patients

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