Current surgical options and innovation for repairing articular cartilage defects in the femoral head

Du, Dexiao; Hsu, Peichun; Zhu, Zhenzhong; Zhang, Changqing

doi:10.1016/j.jot.2019.06.002

Cited by 20 publications

(26 citation statements)

References 67 publications

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“…Despite the high prevalence rate, a universally efficient method for articular cartilage repair is yet to be developed ( 48 ). Current surgical options include arthroplasty, microfracture, and autologous chondrocyte implantation ( 49 ). The promising qualities of MSC-based therapies could potentially provide effective, less invasive procedures to repair articular cartilage defects.…”

Section: Applications Of Msc Therapies For Cartilage Injuriesmentioning

confidence: 99%

Recent Developments in Clinical Applications of Mesenchymal Stem Cells in the Treatment of Rheumatoid Arthritis and Osteoarthritis

et al. 2021

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Mesenchymal stem cell (MSC) therapies have been used as cell-based treatments for decades, owing to their anti-inflammatory, immunomodulatory, and regenerative properties. With high expectations, many ongoing clinical trials are investigating the safety and efficacy of MSC therapies to treat arthritic diseases. Studies on osteoarthritis (OA) have shown positive clinical outcomes, with improved joint function, pain level, and quality of life. In addition, few clinical MSC trials conducted on rheumatoid arthritis (RA) patients have also displayed some optimistic outlook. The largely positive outcomes in clinical trials without severe side effects establish MSCs as promising tools for arthritis treatment. However, further research is required to investigate its applicability in clinical settings. This review discusses the most recent advances in clinical studies on MSC therapies for OA and RA.

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Section: Applications Of Msc Therapies For Cartilage Injuriesmentioning

confidence: 99%

Recent Developments in Clinical Applications of Mesenchymal Stem Cells in the Treatment of Rheumatoid Arthritis and Osteoarthritis

et al. 2021

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“…As a relatively poor self‐healing injury, AC defects of the knee joint are very common in the general and athletic populations (Khajeh, Bozorg‐Ghalati, Zare, Panahi, & Razban, 2020; Schreiner et al, 2020). Currently, several surgical interventions, such as microfracture and osteochondral autografting or allografting, have been developed to treat these cartilage defects (DiBartola, Wright, Magnussen, & Flanigan, 2016; Du, Hsu, Zhu, & Zhang, 2019; Knutsen et al, 2004); however, no treatment has proven to be satisfactory. Many tissue‐engineered approaches have been developed to regenerate cartilage defects.…”

Section: Discussionmentioning

confidence: 99%

Repair of articular cartilage defect using adipose‐derived stem cell‐loaded scaffold derived from native cartilage extracellular matrix

Lü

Shang

Liu

et al. 2021

Journal Cellular Physiology

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The purpose of this study was to investigate the feasibility of adipose-derived stem cells (ADSCs) as the seed cells of cartilage tissue engineering. ADSCs were isolated from adipose tissue that was harvested under sterile conditions from the inguen fold of porcines and cultured in vitro. Acellular cartilage extracellular matrix (ACECM) scaffolds of pigs were then constructed. Moreover, inflammatory cells, as well as cellular and humoral immune responses, were detected using hematoxylin and eosin staining staining, immunohistochemical staining, and western blot analysis. The results showed that the cartilage complex constructed by ADSCs and ACECM through tissue engineering successfully repaired the cartilage defect of the pig knee joint. The in vivo repair experiment showed no significant difference between chondrocytes, ADSCs, and induced ADSCs, indicating that ADSCs do not require in vitro induction and have the potential for chondrogenic differentiation in the environment around the knee joint. In addition, pig-derived acellular cartilage scaffolds possess no obvious immune inflammatory response when used in xenotransplantation. ADSCs may serve as viable seed cells for cartilage tissue engineering.

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“…If the suture is the strongest chondral repair technique [ 9 ] knots or wire on the femoral side may abrade and damage the adjacent acetabular cartilage. Other techniques have been described for the repair of osteochondral defects in femoral head such as mosaicplasty [ 10 , 11 ], allografts [ 10 , 12 ] or retrograde drilling under the subchondral bone, grafting associated with microfracture under arthroscopic assistance [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Unusual apical femoral head deformity treated by hip arthroscopy and tunnel drilling through femoral head: a case report

Morattel¹,

Bonin²

2021

Journal of Hip Preservation Surgery

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Femoro-acetabular impingement (FAI), is the result of an abnormal morphology of the hip joint. On the femoral side, asphericity of the head can be highlighted by an alpha angle measurement >50° on computed tomography or MRI. However, some particular cephalic asphericities can make it difficult to measure the alpha angle, leading to a diagnostic pitfall. While in the classic cam effect, the deformity is peripheral and can be treated by arthroscopic femoroplasty, an apical head deformity remains a therapeutic challenge. We present the case of a 17-year-old male patient with a femoral head deformity, corresponding to an ISHA zone 6 overhang, significantly improved in everyday and sports life by arthroscopic trapdoor technique to resect the focal central deformity while enabling concomitant treatment of central compartment pathology, in this case, a hypertrophic ligamentum teres and femoral head chondral flap. Etiology of this femoral head deformity remains uncertain but could be a particular cam deformity, sequelae to pediatric disease or instability with repeated traction of the ligament teres on the femoral head apical insertion during cephalic growth.

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Current surgical options and innovation for repairing articular cartilage defects in the femoral head

Cited by 20 publications

References 67 publications

Recent Developments in Clinical Applications of Mesenchymal Stem Cells in the Treatment of Rheumatoid Arthritis and Osteoarthritis

Recent Developments in Clinical Applications of Mesenchymal Stem Cells in the Treatment of Rheumatoid Arthritis and Osteoarthritis

Repair of articular cartilage defect using adipose‐derived stem cell‐loaded scaffold derived from native cartilage extracellular matrix

Unusual apical femoral head deformity treated by hip arthroscopy and tunnel drilling through femoral head: a case report

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