Recent Developments in Clinical Applications of Mesenchymal Stem Cells in the Treatment of Rheumatoid Arthritis and Osteoarthritis

Hwang, Joel Jihwan; Rim, Yeri Alice; Nam, Yoonho; Ju, Ji Hyeon

doi:10.3389/fimmu.2021.631291

Cited by 95 publications

(80 citation statements)

References 141 publications

(198 reference statements)

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“…Synovial-MSCs (S-MSCs) isolated and characterized first in 2001, are also promising tools for the treatment OA due to their natural homing in this site [70]. They were shown to have high chondrogenic differentiation capacities, high expression of type II collagen, compared to other sources of MSCs [71,72].…”

Section: Adipocyte Derived Stem Cell Role In Regenerate Knee Osteoarthritismentioning

confidence: 99%

“…So far, there have been few approved clinical application for the MSCs in different countries. Few examples, are the application of allogeneic MSCs for the treatment of graft versus host disease (GVHD) in Japan, autologous bone marrow MSCs for amyotrophic lateral sclerosis and autologous adipose MSCs for Chron's fistula, human umbilical cord blood-derived MSCs for osteoarthritis in South Korea, and in Europe the application of allogenic adipose MSCs for the treatment of fistulas in Crohn's disease [70].…”

Section: Clinical Trials With Ascsmentioning

confidence: 99%

“…The application of MSCs for knee repair showed to be more effective with fewer side effects from the surgical procedure of the isolation of chondrocytes [96]. There are many clinical trials on the applications of the MSCs for OA [70].…”

Section: Clinical Trials With Ascsmentioning

confidence: 99%

See 2 more Smart Citations

The Regenerative Effect of Intra-Articular Injection of Autologous Fat Micro-Graft in Treatment of Chronic Knee Osteoarthritis

Kahtani¹,

Yami²,

Qahtani³

et al. 2022

Rheumatoid Arthritis

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Osteoarthritis (OA) is one of the most prevalent conditions resulting to disability particularly in elderly population About 13% of women and 10% of men aged 60 years and older have symptomatic knee OA. The proportions of people affected with symptomatic knee OA is likely to increase due to the aging of the population and the rate of obesity or overweight in the general population. There are multiple factors associated with this progressive disease such as obesity, female gender, and repetitive trauma. Pain is the most common symptom in knee OA, a leading cause of chronic disability, clinical diagnosis will be supported by certain radiological findings. There are numerous conservative therapies that help to relive symptoms depend on severity of Osteoarthritis, and knee replacement remains standard of care in advance disease. Fat Micrografting is evolving technique with promising result in selected patients with regenerative and reparative effect of adipocyte-derived stem cell toward damaged cartilage and bone, which supported by clinical evidence.

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Section: Adipocyte Derived Stem Cell Role In Regenerate Knee Osteoarthritismentioning

confidence: 99%

Section: Clinical Trials With Ascsmentioning

confidence: 99%

See 1 more Smart Citation

The Regenerative Effect of Intra-Articular Injection of Autologous Fat Micro-Graft in Treatment of Chronic Knee Osteoarthritis

Kahtani¹,

Yami²,

Qahtani³

et al. 2022

Rheumatoid Arthritis

View full text Add to dashboard Cite

show abstract

“…Significant numbers of other clinical trials are dealing with the use of MSCs' immunomodulatory properties as standalone therapy for various diseases and conditions associated with overactivated immune systems. MSCs were tested for treatment of rheumatoid arthritis and osteoarthritis [225], multiple sclerosis [226], inflammatory bowel disease [227], systemic lupus erythematosus [228], diabetes mellitus [229], among other pathologies. In most reported cases, good safety profiles and encouraging outcomes were reported.…”

Section: Translation To the Clinicmentioning

confidence: 99%

Hematopoiesis during Ontogenesis, Adult Life, and Aging

Belyavsky

Petinati

2021

IJMS

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In the bone marrow of vertebrates, two types of stem cells coexist—hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs). Hematopoiesis only occurs when these two stem cell types and their descendants interact. The descendants of HSCs supply the body with all the mature blood cells, while MSCs give rise to stromal cells that form a niche for HSCs and regulate the process of hematopoiesis. The studies of hematopoiesis were initially based on morphological observations, later extended by the use of physiological methods, and were subsequently augmented by massive application of sophisticated molecular techniques. The combination of these methods produced a wealth of new data on the organization and functional features of hematopoiesis in the ontogenesis of mammals and humans. This review summarizes the current views on hematopoiesis in mice and humans, discusses the development of blood elements and hematopoiesis in the embryo, and describes how the hematopoietic system works in the adult organism and how it changes during aging.

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“…Both OA and RA do not yet have an ideal therapy that can fully cure the disease [ 12 ]. In the case of RA, the overall goal is to relieve pain and decrease inflammation [ 13 ].…”

Section: Ac and Arthritic Diseasesmentioning

confidence: 99%

Minicircles for Investigating and Treating Arthritic Diseases

2021

Self Cite

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Gene delivery systems have become an essential component of research and the development of therapeutics for various diseases. Minicircles are non-viral vectors with promising characteristics for application in a variety of fields. With their minimal size, minicircles exhibit relatively high safety and efficient delivery of genes of interest into cells. Cartilage tissue lacks the natural ability to heal, making it difficult to treat osteoarthritis (OA) and rheumatoid arthritis (RA), which are the two main types of joint-related disease. Although both OA and RA affect the joint, RA is an autoimmune disease, while OA is a degenerative joint condition. Gene transfer using minicircles has also been used in many studies regarding cartilage and its diseased conditions. In this review, we summarize the cartilage-, OA-, and RA-based studies that have used minicircles as the gene delivery system.

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Recent Developments in Clinical Applications of Mesenchymal Stem Cells in the Treatment of Rheumatoid Arthritis and Osteoarthritis

Cited by 95 publications

References 141 publications

The Regenerative Effect of Intra-Articular Injection of Autologous Fat Micro-Graft in Treatment of Chronic Knee Osteoarthritis

The Regenerative Effect of Intra-Articular Injection of Autologous Fat Micro-Graft in Treatment of Chronic Knee Osteoarthritis

Hematopoiesis during Ontogenesis, Adult Life, and Aging

Minicircles for Investigating and Treating Arthritic Diseases

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