Current Strategies of Quetiapine Fumarate Delivery in Management of Bipolar Disorder and Schizophrenia

Patil, Deepak; Pattewar, Seema; Paliwal, Sarvesh Paliwal; Singh, Gyanendra Pratap; Sharma, Swapnil

doi:10.18314/jpt.v5i1.1554

Cited by 1 publication

(1 citation statement)

References 17 publications

(19 reference statements)

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“…The water was allowed to evaporate at room temperature left for 24 h. dried films were collected and kept in desiccator for further use. [20] Further, the ETTS were developed by precisely measuring an amount of hydrogel equivalent to 10 mg of drug and putting it on the backing layer; prepared RCMs were placed upon hydrogel reservoir and to avoid leakage from the system, the edges were sealed by applying heat and were stored in a closed container. The schematic diagram is shown in Figure (1) and composition of ETTS is given in Tables 1 Table 1 Formulation details of PAAm-g-GaG based ETTS…”

Section: Rate Controlling Membranesmentioning

confidence: 99%

Development and evaluation of antipsychotic drugs for externally triggered transdermal therapeutic systems

Sonavane

Babar

Phadtare

et al. 2022

ijhs

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Cariprazine is a recent antipsychotic drug with an atypical neuropharmacological profile. It is promptly absorbed from the GI tract and suddenly metabolized by liver. Cariprazine has 6 h of plasma elimination half life, 9% of oral and 83% of protein binding. Administration of cariprazine in transdermal dosage form would be a lot of fascinating to regulate the mood for extended period by achieving the plasma concentration well higher than the therapeutic levels. With psychiatrical patients, schedules of daily medication should be followed to avoid adverse reactions which are notably difficult. Therefore, delivery of such drugs by transdermal route can be done. Development and maintenance of low dose drugs therapy is desired, which will limit the consequences of significant adverse effect and direct the issues of helpless consistence in the patients. Ideal quantity of the psychotropic drug can be given by transdermal route with least adverse reactions to overcome the psychic conditions. This will result in improving the health care services for long term mental illness management. In present work, we have synthesized the novel electrically responsive graft co-polymers using natural polymers with polyacrylamide and utilized for the preparation of cariprazine containing electrically responsive transdermal therapeutic systems (ETTS).

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Section: Rate Controlling Membranesmentioning

confidence: 99%