Current status of zinc in health and disease states.

Aggett, Peter; Harries, J T

doi:10.1136/adc.54.12.909

Cited by 162 publications

(59 citation statements)

References 83 publications

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“…Zinc is passively transferred from mother to fetus across the placenta (19) and there is also decreased zinc binding capacity of maternal blood during pregnancy which facilitates efficient transfer of zinc from mother to fetus resulting in an increase level of zinc in cord blood. Zinc is essential for proper growth of fetus and the fall in zinc during pregnancy could also be a physiological response to expanded maternal blood volume (20,21,22).…”

Section: Discussionmentioning

confidence: 99%

Serum iron, copper and zinc status in maternal and cord blood

Upadhyaya

Mishra

Ajmera

et al. 2004

Indian J Clin Biochem

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Pregnancy is associated with increased demand of all the nutrients like Iron, Copper, Zinc etc. and deficiency of any of these could affect pregnancy, delivery and out come of pregnancy. With this consideration, the study was conducted on 80 mothers and newborns and 20 age matched control women. Out of 80 mothers, 34 had Iron deficiency anemia and their Hb levels were below 9.0 gm/d'. Pregnant women had significantly lower Iron and Zinc levels while Copper and Total Iron Binding Capacity (I'IBC) were significantly higher (P<0.001). Newborns had significantly elevated Iron and Zinc levels and low levels of Copper and TIBC as compared to their mothers irrespective of Iron deficiency anemia. Micronutrient status of newborn was found to be dependent on their mother's micronutrient status. Besides, results also suggest micronutrient interactions, which are reflected in Iron/Zinc, Iron/Copper and Zinc/Copper ratios. In view of this, there is need for proper, adequate and balanced micronutrient supplementation during pregnancy to affect a healthy outcome.

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Section: Discussionmentioning

confidence: 99%

Serum iron, copper and zinc status in maternal and cord blood

Upadhyaya

Mishra

Ajmera

et al. 2004

Indian J Clin Biochem

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“…The authors believed that hair is a reliable specimen for retrospective search of trace elements status of the body. Unlike blood, serum, and urine, the hair, in addition to being less traumatic to the patient, provides historical information on concentrations of trace elements in the body as well as nutritional condition over a long period of time (74,79,80). Furthermore, trace elements are more concentrated in the hair than in the body fluids.…”

Section: Zincmentioning

confidence: 99%

Trace Elements and Electrolytes Homeostasis and Their Relation to Antioxidant Enzyme Activity in Brain Hyperexcitability of Epileptic Patients

Hamed

Abdellah

2004

J Pharmacol Sci

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Abstract. Epileptogenesis is a big challenge. Various experimental and human studies suggested that the homeostasis of trace elements, electrolytes, membrane lipid peroxidation, and antioxidants is crucial for brain function, and they were directly or indirectly implicated as taking part in the pathophysiology of neuronal excitability, neuronal excitotoxicity, and seizure recurrence and its resistance to treatment with antiepileptic drugs (AEDs). In addition, AEDs can also alter the homeostasis of trace elements, electrolytes, and seriously increase membrane lipid peroxidation at the expense of protective antioxidants, leading to an increase in seizure recurrence and an idiosyncratic drug effect. Differential effects were detected among different AEDs treatments in which carbamazepine (CBZ) was found to be better anticonvulsant for the control of free radical related seizures and the level of trace elements were better regulated with CBZ than with valproate (VPA) and phenytoin (PHT) therapies. It is concluded that adequate trace elements and antioxidants supply is important for brain functions and prevention of neurological diseases and further elucidation of the pathological actions of such substances in the brain should result in new therapeutic approaches. Trace elements and antioxidant might have neuroprotective biological targeted benefits when used in epileptic patients.

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“…Whole blood, serum, and urine levels may show variability throughout a day; however, unlike blood serum and urine, hair provides historical information about intracellular accumulations and concentrations of trace elements in the body as well as nutritional condition over a long time (19)(20)(21).…”

Section: Discussionmentioning

confidence: 99%

Selenium status in blood, urine, and hair samples of newly diagnosed pediatric cancer patients

Karaman¹,

Mansuroğlu²,

Kızılbey³

et al. 2015

Turk J Med Sci

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Background/aim: Selenium (Se) is a trace element that has multiple functions. Low Se amounts in serum and hair have been reported in pediatric and adult cancer patients. The aim of our study was to evaluate Se levels in the serum, urine, and hair of pediatric cancer patients with leukemia, lymphoma, and solid tumors when compared with healthy children. Materials and methods:The concentrations of Se in the serum, hair, and urine of 32 Turkish children as healthy controls and 88 Turkish children diagnosed with acute leukemia (58), lymphoma (16), and solid tumors (14) were measured using inductively coupled plasma mass spectroscopy.Results: Se levels in the serum and hair of the children with cancer were significantly lower than those of the controls. There were no differences between the leukemia, lymphoma, and solid tumors group. On the other hand, the Se levels of the urine samples were slightly elevated in cancer patients compared with the control group. There was no marked difference in the Se levels of patients with different types of cancer. Conclusion:Se deficiency might be associated with the development of pediatric cancer. Especially in children, additional studies are needed to define whether low levels of Se may play a role in cancer pathogenesis.

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Current status of zinc in health and disease states.

Cited by 162 publications

References 83 publications

Serum iron, copper and zinc status in maternal and cord blood

Serum iron, copper and zinc status in maternal and cord blood

Trace Elements and Electrolytes Homeostasis and Their Relation to Antioxidant Enzyme Activity in Brain Hyperexcitability of Epileptic Patients

Selenium status in blood, urine, and hair samples of newly diagnosed pediatric cancer patients

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