Current status of nephrotoxicity caused by non-steroidal anti-inflammatory drugs

Prescott, L. F.; Martin, Una

doi:10.1007/978-94-011-2982-4_27

Cited by 3 publications

(1 citation statement)

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“…In relation to OTC use of ibuprofen and its possible association with the development of nephrotoxicity adverse reactions it is been noted that analgesic nephropathy is not been widely recognized or reported effect of renal OTC ibuprofen (Mann et al 1993) and certainly this is only infrequently reported in ADR reports made to the UK CSM (Prescott and Martin 1992). In the analysis of risks of renal side effects of ibuprofen by Mann et al (1993), it was found that the renal effects are dose-dependent and these effects are almost exclusively in elderly subjects with low intravascular volume and low cardiac output.…”

Section: Renal Toxicitymentioning

confidence: 94%

Ibuprofen: pharmacology, efficacy and safety

2009

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This assessment of the safety and benefits of ibuprofen can be summarized thus: (1) Ibuprofen at OTC doses has low possibilities of serious GI events, and little prospect of developing renal and associated CV events. Ibuprofen OTC does not represent a risk for developing liver injury especially the irreversible liver damage observed with paracetamol and the occasional liver reactions from aspirin. (2) The pharmacokinetic properties of ibuprofen, especially the short plasma half-life of elimination, lack of development of pathologically related metabolites (e.g. covalent modification of liver proteins by the quinine-imine metabolite of paracetamol or irreversible acetylation of biomolecules by aspirin) are support for the view that these pharmacokinetic and notably metabolic effects of ibuprofen favour its low toxic potential. (3) The multiple actions of ibuprofen in controlling inflammation combine with moderate inhibition of COX-1 and COX-2 and low residence time of the drug in the body may account for the low GI, CV and renal risks from ibuprofen, especially at OTC doses.

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Section: Renal Toxicitymentioning

confidence: 94%