Current status of liver diseases in Korea: Hepatitis B

Chae, Hee Bok; Kim, Jong Hyun; Kim, Ja Kyung; Yim, Hyung Joon

doi:10.3350/kjhep.2009.15.s6.s13

Cited by 85 publications

(72 citation statements)

References 42 publications

(32 reference statements)

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“…3 In our study, 22 (4.6%) of the 477 study subjects with IgAN had HBs antigenemia; this was slightly lower than the prevalence of HBsAg carriers in the general population, which was reported to be 5.7% in the 1990s. 16 The detection rate of HBV-specific antigens was 10% in this study (Figure 2), which was lower than that (59%) of previous reports. 2 Thus, it does not appear likely that HBV plays an important role in the pathogenesis of IgAN.…”

Section: Discussioncontrasting

confidence: 54%

Clinical Characteristics and Treatment of Patients with IgA Nephropathy and Hepatitis B Surface Antigen

et al. 2013

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Background: The aim of this study is to investigate the clinical characteristics and our experience of treating patients with IgA nephropathy (IgAN) and IgA nephropathy with hepatitis B surface antigen (HBs-IgAN). Methods: From 1996 to 2011, biopsy-proven IgAN was diagnosed in 477 patients and 22 (4.6%) had hepatitis B surface antigen (HBsAg). Of these, we included 360 patients who had more than 6-month follow-up period, and compared clinical characteristics and renal function decline between the patients with IgAN and HBs-IgAN. Results: Of 360 patients, 22 were classified as HBs-IgAN. There were no differences in the clinical characteristics and renal function decline between idiopathic IgAN and HBs-IgAN (-0.01 vs. -0.17 mL/min per 1.73 m 2 /month, p ¼ 0.319). Of 22 patients with HBs-IgAN, nine had hepatitis B virus (HBV) replication marker (RM), of which six were treated with anti-viral agents. However, there were no differences in renal function decline and urinary protein excretion between patients who did or did not receive anti-viral therapy. Five patients with HBs-IgAN received corticosteroid therapy. Of these, three without HBV RM and one with HBV RM who received entecavir did not exhibit active viral replication, whereas the other patients with HBV RM experienced viral replication after lamivudine was discontinued. Conclusion: There were no differences in the clinical characteristics and prognosis between the patients with IgAN and HBs-IgAN. Further, there were no differences in renal function decline and urinary protein excretion between patients with and without anti-viral therapy. Anti-viral therapy may be considered for treating patients with HBs-IgAN receiving immunosuppressants according to HBV RM.

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Section: Discussioncontrasting

confidence: 54%

Clinical Characteristics and Treatment of Patients with IgA Nephropathy and Hepatitis B Surface Antigen

et al. 2013

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“…However, when we compared the HBsAg seroclearance rate for the same age group of less than 39 years of age, the HBsAg seroclearance rate in our study was lower (0.48%) compared to 0.96% in the Taiwan study [4]. It may be explained by the difference in viral genotypes between Korea (exclusively genotype C) and Taiwan (genotype B and C) [13,14,15,16,17]. The genotype might also affect the serum HBsAg levels and HBsAg seroclearance rates [9,18,19].…”

Section: Discussioncontrasting

confidence: 38%

“…The positive relationship between age and the HBsAg seroclearance rate was also suggested previously by Korean epidemiological data. According to a report by the Korean National Health and Nutrition Examination Survey, the rate of HBsAg positivity decreased markedly after the seventh decade of age, which can be explained by the increased HBsAg seroclearance in elderly patients [17,20]. In Korea, vertical transmission from mothers to infants occupies more than 85% of HBV infections [17,21].…”

Section: Discussionmentioning

confidence: 99%

Predictors of HBsAg Seroclearance in HBeAg-Negative Chronic Hepatitis B Patients

Kwak¹,

Cho²,

Jang³

et al. 2011

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Background and Aims: In chronic hepatitis B virus (HBV) infections, hepatitis B surface antigen (HBsAg) seroclearance reportedly occurs at a rate of 0.50–2.26%. Several factors were suggested to be associated with seroclearance including age and HBeAg negativity. However, there are few studies evaluating whether HBV DNA levels are an independent predictor of HBsAg seroclearance. The aim of this study was to evaluate the annual HBsAg seroclearance rate and its predictors including serum HBV DNA levels in HBeAg-negative chronic hepatitis B patients. Methods: We included 880 HBeAg-negative chronic hepatitis B patients who underwent an evaluation of baseline serum HBV DNA levels. We reviewed the electronic charts for baseline clinical, biochemical, and virological factors. Results: The median age was 50 years, and the follow-up duration was 31 months. The annual rate for the HBsAg seroclearance was 1.8%. In multivariable analysis, the probability of HBsAg seroclearance was positively associated with old age (p = 0.046), with a sustained inactive phase rather than the occurrence of HBeAg-negative hepatitis (p = 0.041), and with an initial HBV DNA level <2,000 IU/ml (p = 0.001). Conclusion: The annual rate for the HBsAg seroclearance in HBeAg-negative chronic hepatitis B patients was 1.8%. Old age, sustained inactive phase, and low levels of HBV DNA were independent predictors of HBsAg seroclearance.

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“…HBV infection is endemic in South Korea (7). According to the Korean National Health and Nutrition Examination Survey (KNHANES) conducted in 2010, the prevalence rate of the HBV surface antigen (HBsAg) among people aged 10 or older was about 3.0z.…”

Section: Introductionmentioning

confidence: 99%

The Economic Burden of Hepatitis A, B, and C in South Korea

et al. 2016

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SUMMARY:The prevalence of hepatitis in South Korea is relatively high compared to that in other high-income countries. For this reason, viral hepatitis infection not only affects the population's health, but also impacts national healthcare costs. This study was performed in order to estimate the individual economic costs of the hepatitis A, B, and C viruses as well as to determine, using nationally representative data, the trends in South Korea with respect to these viruses during the 2008-2011 period. The study found that the prevalence of hepatitis A had decreased, but those of hepatitis B and C had increased overall. The mortality rate of hepatitis C was higher than that of the other two types. The mortality rate of hepatitis B had changed little, whereas that of hepatitis C had risen.

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Current status of liver diseases in Korea: Hepatitis B

Cited by 85 publications

References 42 publications

Clinical Characteristics and Treatment of Patients with IgA Nephropathy and Hepatitis B Surface Antigen

Clinical Characteristics and Treatment of Patients with IgA Nephropathy and Hepatitis B Surface Antigen

Predictors of HBsAg Seroclearance in HBeAg-Negative Chronic Hepatitis B Patients

The Economic Burden of Hepatitis A, B, and C in South Korea

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