Current status of liver diseases in Korea: Toxic and alcoholic liver diseases

Kim, Kyung-Ah

doi:10.3350/kjhep.2009.15.s6.s29

Cited by 15 publications

(11 citation statements)

References 10 publications

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“…A high propensity toward combined alcohol and nicotine use was observed in Korean adults; this result is similar to the results from other population-based studies that independently found a significant association between alcohol use disorder and smoking (Hasin, Stinson, Ogburn, & Grant, 2007;Kim et al, 2009). Codependence on alcohol and nicotine is the most common cause of preventable morbidity and mortality in the world (Ait-Daoud et al, 2005;Bien & Burge, 1990).…”

Section: Discussionsupporting

confidence: 91%

“…Despite the recent interest in viral hepatitis-induced liver disease, alcohol consumption continues to be a common cause of acute and chronic liver disease (Kim, 2009;Savolainen, Liesto, Mannikko, Penttila, & Karhunen, 1993). ALD encompasses a spectrum of injury, ranging from minimal abnormalities of hepatic steatosis to more significant signs and symptoms of liver disease related to inflammation or frank advanced fibrosis, or both; however, individuals with ALD may be entirely asymptomatic (Levitsky & Mailliard, 2004).…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of Alcoholic Liver Disease Among Korean Adults: Results From the Fourth Korea National Health and Nutrition Examination Survey, 2009

Park

Kim

et al. 2011

Substance Use & Misuse

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Prevalence of Alcoholic Liver Disease Among Korean Adults: Results From the Fourth Korea National Health and Nutrition Examination Survey, 2009

Park

Kim

et al. 2011

Substance Use & Misuse

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“…Vesivirus in environmental reservoirs include infected wild animals, food animals (swine, cattle), fin‐fish, and aquatic filter feeders such as mussels, clams and oysters, which can concentrate virus from the water [Smith et al, 1998b; Smith, 2000; Terio et al, 2010; Westrell et al, 2010]. Liver function may also be affected by Korean food, alcohol consumption, and traditional, medicine and these may exacerbate liver disease [Kim, 2009]. Therefore, the Korean people may be more susceptible to symptomatic Vesivirus infections and if so, data reported above may reflect a culturally associated increase in vesiviral liver disease among Koreans.…”

Section: Discussionmentioning

confidence: 99%

Elevated post‐transfusion serum transaminase values associated with a highly significant trend for increasing prevalence of anti‐Vesivirus antibody in Korean patients

Lee¹,

Cho²,

Park³

et al. 2012

Journal of Medical Virology

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A highly significant increase in anti-Vesivirus (family Caliciviridae) antibody prevalence, along the axis from healthy blood donors; donors with elevated transaminase; patients with clinical hepatitis; and patients with post-transfusion/dialysis hepatitis, has been reported in human sera from the USA and Europe. Asian samples have now been tested retrospectively using serology and enzyme immunoassay (EIA) with a Vesivirus partial-capsid antigen expressed as a fusion protein. Anti-vesiviral antibodies were measured by optical densities (OD(650)) and compared in patients separated by age, gender and Groups A-F as follows: Control Group A, an Experimental Group B, which was divided further into Group C, patients with elevated enzymes (alanine transaminase (ALT), aspartate transaminase (AST), and γ-glutamyl transpeptidase (γ-GT); Group D, patients receiving transfused blood; Group E, patients with high enzyme levels after transfusion; and Group F, hepatitis B and C positive patients. Using multivariate logistic regression analyses, a significantly greater proportion of patients receiving transfusion(s), were positive for anti-Vesivirus antibody compared with non-transfused patients (P = 0.008; OR: 3.86, 95% CI: 1.43-10.43). Also, anti-Vesivirus antibody was significantly associated with elevated biochemical liver function tests: ALT ≥ 20 IU or AST ≥ 120 IU (P = 0.017; OR: 4.23, 95% CI: 1.30-13.80). In the blood transfusion group, anti-Vesivirus antibody was significantly correlated with high enzyme levels (ALT, P = 0.018; AST, P = 0.010; γ-GT, P = 0.020). These data provide serologic evidence of vesiviral transfusion-transmission-associated disease, which could include infection of any organ system where cytopathology resulted in high levels of either ALT or AST.

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“…According to recent studies, 7-31% of chronic liver diseases are alcoholic liver diseases 3,4. Nevertheless, because drinking rates are substantial in chronic hepatitis B and hepatitis C patients, more patients than expected may be affected by alcohol.…”

Section: Introductionmentioning

confidence: 99%

Genetic polymorphism at codon 10 of the transforming growth factor-β1 gene in patients with alcoholic liver cirrhosis

et al. 2011

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Background/AimsTransforming growth factor beta1 (TGF-β1) is a key cytokine in the production of extracellular matrix. A genetic polymorphism at codon 10 of the TGF-β1 gene is associated with liver fibrosis. We investigated the effect of genetic polymorphisms at codon 10 on the development of alcoholic liver cirrhosis (ALC).MethodsIn total, 119 controls and 182 patients with ALC, were enrolled in the study. Clinical and laboratory data including total lifetime alcohol intake were collected at enrollment. The genotype at codon 10 was determined for each patient by single-strand conformation polymorphism.ResultsThere were three types of genetic polymorphism at codon 10: homozygous proline (P/P), heterozygous proline/leucine (P/L), and homozygous leucine (L/L). Among the controls, the proportions of P/P, P/L, and L/L were 26.1%, 44.5%, and 29.4%, respectively in the ALC group, these proportions were 23.1%, 43.4%, and 33.5%, respectively. The genotype distribution did not differ between the controls and the ALC group. In the ALC group, age, total lifetime alcohol intake, and distribution of Child-Pugh class did not differ with the genotype. Of the male patients with ALC (n=164), the proportions of P/P, P/L, and L/L were 20.1%, 44.5%, and 35.4%, respectively the genotype distribution did not differ between the male controls and the male ALC patients.ConclusionsThe genotype at codon 10 in TGF-β1 does not appear to influence the development of ALC. Further study is needed to investigate other genetic factors that influence the development of ALC in patients with chronic alcohol intake.

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Current status of liver diseases in Korea: Toxic and alcoholic liver diseases

Cited by 15 publications

References 10 publications

Prevalence of Alcoholic Liver Disease Among Korean Adults: Results From the Fourth Korea National Health and Nutrition Examination Survey, 2009

Prevalence of Alcoholic Liver Disease Among Korean Adults: Results From the Fourth Korea National Health and Nutrition Examination Survey, 2009

Elevated post‐transfusion serum transaminase values associated with a highly significant trend for increasing prevalence of anti‐Vesivirus antibody in Korean patients

Genetic polymorphism at codon 10 of the transforming growth factor-β1 gene in patients with alcoholic liver cirrhosis

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