Current status of human rabies prevention: remaining barriers to global biologics accessibility and disease elimination

Rupprecht, Charles E.; Salahuddin, Naseem

doi:10.1080/14760584.2019.1627205

Cited by 33 publications

(24 citation statements)

References 97 publications

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“…Investigations from the past five years estimated the epidemiological and economic impact of intervention strategies strongly supporting the effectiveness of canine vaccination and equitable access to PEP in populations residing in endemic regions [7][8][9][10][11]. Understanding the progress of individual countries and the disparity of infrastructure and programs within countries across the continent will be crucial for the implementation of targeted control and prevention strategies for canine rabies.…”

Section: Introductionmentioning

confidence: 99%

Challenges to the Fight against Rabies—The Landscape of Policy and Prevention Strategies in Africa

Haselbeck

Rietmann

Tadesse

et al. 2021

IJERPH

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Nearly 59,000 human deaths worldwide are attributable to rabies annually, of which more than a third occur in Africa. In recent years, progress has been made in both action and collaboration including implementation of surveillance and prevention measures. In this review we assess the scale of surveillance, preventive, and control efforts of canine-transmitted human rabies in African countries. We reviewed literature published from 2014 to 2018, retrieved from electronic databases including MEDLINE, Global Index Medicus, BIOSIS, Science Citation Index, and EMBASE. WHO reports, national disease control program reports, and conference proceedings were also reviewed. The database search was conducted using keywords including rabies, control, and prevention. In forty countries (40/54), some level of rabies control and prevention strategy was available while in fourteen (14/54) countries, no specific national control and prevention strategy for human rabies could be retrieved. Thirty-four (34/54) countries utilized the Stepwise Approach towards Rabies Elimination (SARE) tool to monitor the national rabies control efforts—five of these countries were at the lowest tier (0/5) of the SARE scoring system while no country had achieved the highest score (5/5). High burden countries need to step up the implementation of context specific national rabies control, prevention, and monitoring strategies. As a zoonosis, rabies control and elimination require coordination between human and veterinarian health sectors under the “One Health” umbrella and with national master plans on the prevention and control of neglected tropical diseases ending in 2020, the time to act is now.

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Section: Introductionmentioning

confidence: 99%

Challenges to the Fight against Rabies—The Landscape of Policy and Prevention Strategies in Africa

Haselbeck

Rietmann

Tadesse

et al. 2021

IJERPH

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“…Warm-blooded vertebrates, including humans, are susceptible to rabies-a vaccinepreventable and neglected tropical zoonotic disease that is characterized by acute, nearly 100% fatal neurological complications [1,2]. The RNA viruses of the Lyssavirus genus, family Rhabdoviridae, are all known or suspected to induce rabies, although the main etiological agent for rabies worldwide remains rabies virus (RABV) [3,4].…”

Section: Introductionmentioning

confidence: 99%

The Role of Waste Management in Control of Rabies: A Neglected Issue

Wright

Subedi

Pantha

et al. 2021

Viruses

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Despite being vaccine preventable, the global burden of dog rabies remains significant, and historically it is the rural and marginalized communities in developing countries of Africa and Asia that are most threatened by the disease. In recent years, the developing world has been experiencing unprecedented increases in urbanization, with a correspondingly massive increase in municipal solid waste generation, among other things. Inefficient and inadequate waste collection and management, due to lack of resources and planning, led to significant increases in the volumes of waste on the streets and in open dumps, where it serves as food sources for free-roaming dogs. In this commentary, we discuss examples of poor waste management and the likely impact on rabies control efforts through the sustenance of free-roaming dogs in some dog rabies-endemic countries. We aim to stress the importance of implementing strategies that effectively address this particular issue as an important component of humane dog population management, as it relates to aspirations for the control and elimination of dog rabies per se.

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“…Rabies is an acute, progressive encephalitis caused by Rabies lyssavirus . 5 – 8 The disease is fatal if not treated effectively soon after a bite from a rabid dog, whose saliva contains rabies virions. Once inoculated into the skin or mucous membranes, the virus travels gradually along nerve axons towards the central nervous system and results in acute, progressive encephalitis.…”

Section: Introductionmentioning

confidence: 99%