Current Status of Chemotherapy in the Treatment of Head and Neck Cancer

Woods, John E.

doi:10.1001/archsurg.1976.01360280013001

Arch Surg

1976

DOI: 10.1001/archsurg.1976.01360280013001

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Current Status of Chemotherapy in the Treatment of Head and Neck Cancer

John E. Woods¹

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1977

1986

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Cited by 10 publications

References 14 publications

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Effect of bleomycin-radiotherapy combination in management of head and neck squamous cell carcinoma

Shah

Shukla

Patel

et al. 1981

Cancer

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Twenty-five patients with head and neck squamous cell carcinoma were treated with bleomycin-radiotherapy protocol, 15 mg bleomycin I.V. on alternate days followed by radiation within half an hour. The average total dose of bleomycin was 150 mg. Radiotherapy was given daily. Two patients were lost to follow-up very early in the course of the treatment and were removed from the study for statistical purposes. Thirty-six patients with head and neck squamous cell carcinoma who were treated with radiotherapy alone during the same period were used as controls. The patients were followed for two years. The incidence of response rate did not differ significantly between regimens; however the incidence of side effects with bleomycin-radiotherapy, 82.61%, is significantly more than that of radiotherapy alone (52.78%). Median survival time (MST) of those responding to bleomycin-radiotherapy protocol was seven months and 12 days and for radiotherapy responders was six months. Neither the response rate nor the MST improve significantly after pretreatment with bleomycin. On the contrary, the incidence of side effects increased significantly.

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Effect of bleomycin-radiotherapy combination in management of head and neck squamous cell carcinoma

Shah

Shukla

Patel

et al. 1981

Cancer

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A preliminary report on the suitability of sheep epidermal squamous cell carcinoma as a solid tumor model in the evaluation of intra‐arterial methotrexate administration

Harker

Stephens

Wass

et al. 1986

Journal of Surgical Oncology

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A preliminary study was undertaken to assess the sensitivity of sheep epidermal squamous cell carcinoma, in the head and neck region, to intra-arterial (IA) methotrexate (MTX) infusion. There was an objective tumor response (40-56% regression) in all three IA-infused sheep, whereas tumor progression was observed in all three animals treated intravenously (IV). Regional and systemic side effects were negligible in all cases. Technically, IA drug infusion in the sheep was an improvement on previous small animal models, with no problems related to arterial catheter insertion, blockage, or dislodgement, and tolerable infusion times being of markedly longer duration. The histological differentiation of moderately differentiated stage II lesions improved during therapy irrespective of clinical response, whilst the histology of well-differentiated stage III and IV tumors remained unchanged. Tumor cell cycle stage and ploidy characteristics, as determined by flow cytometric DNA analysis, were little affected by either mode of drug administration. It is concluded that sheep epidermal carcinoma is responsive to IA MTX, and that this animal model is the most appropriate yet utilised to study the comparative effects of IA and IV chemotherapy in the head and neck region.

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Chemoimmunotherapy of head and neck cancer

Khandekar

DeWys²

1978

The American Journal of Surgery

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Current Status of Chemotherapy in the Treatment of Head and Neck Cancer

Cited by 10 publications

References 14 publications

Effect of bleomycin-radiotherapy combination in management of head and neck squamous cell carcinoma

Effect of bleomycin-radiotherapy combination in management of head and neck squamous cell carcinoma

A preliminary report on the suitability of sheep epidermal squamous cell carcinoma as a solid tumor model in the evaluation of intra‐arterial methotrexate administration

Chemoimmunotherapy of head and neck cancer

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