Current status of carbazole hybrids as anticancer agents

Wang, Gangqiang; Sun, Shi‐Gang; Guo, Hua

doi:10.1016/j.ejmech.2021.113999

Cited by 38 publications

(31 citation statements)

References 105 publications

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“…FTIR (cm (29), 508 (M + , 100), 507 (18), 506 (54), 428 (10), 257 (15), 255 (11), 254 (17), 243 (14), 241 (11), 174 (14), 173 (18), 167 (14), 166 (21). FTIR (cm (10), 294 (23), 293 (31), 292 (55), 258 (11), 257 (14), 182 (70), 181 (100), 167 (13), 166 (11), 129 (17), 128 (37), 127 (15), 77 (18), 75 (22), 51 (13). ).…”

Section: Characterization Data Of Compounds 5 Andmentioning

confidence: 99%

“…). FTIR (cm (19), 339 (11), 337 (11), 258 (46), 257 (18), 256 (20), 168 (15), 167 (100), 166 (40), 129 (35), 128 (47). FTIR (cm…”

Section: Characterization Data Of Compounds 5 Andmentioning

confidence: 99%

“…, 258 (13), 257 (19), 256 (30), 255 (12), 181 (12), 168 (12), 167 (82), 166 (27), 154 (15), 139 (12), 129 (33), 128 (49), 127 (12), 77 (10), 76 (13), 75 (12), 63 (13). FTIR (cm 24), 420 (11), 419 (M + , 48), 417 (26), 341 (19), 340 (98), 339 (22), 338 (100), 259 (22), 258 (62), 257 (16), 168 (12), 157 (53), 156 (20), 155 (12), 130 (11), 129 (64), 128 (24), 115 (12), 77 (24), 76 (18), 75 (17), 65 (11), 51 (11). FTIR (cm (11), 418 (10), 403 (13), 256 (14), 250 (24), 215 (15), 181 (16), 167 (16), 153 (24), 140 (11), 78 (30), 71 (11), 63 (34), 57…”

Section: Characterization Data Of Compounds 5 Andunclassified

“…FTIR (cm (11), 418 (10), 403 (13), 256 (14), 250 (24), 215 (15), 181 (16), 167 (16), 153 (24), 140 (11), 78 (30), 71 (11), 63 (34), 57 (14). FTIR (cm (24), 334 (100), 333 (16), 332 (11), 167 (39), 166 (12), 140 (11)…”

Section: Characterization Data Of Compounds 5 Andmentioning

confidence: 99%

“…[9] Besides, they have been identified as important bioskeletons in several natural products and several carbazole derivatives such as bismahanine [10] show excellent anticancer activity. [11] Synthesis of BiCz is usually achieved by transition-metalbased CÀ C intermolecular coupling reactions, starting from two carbazole moieties. [3,12,13] In this way, the most used methodology for the synthesis of 3,3'-bicarbazole involves FeCl 3 anhydrous in dry chloroform (Scheme 1, eq.…”

Section: Introductionmentioning

confidence: 99%

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Construction of 3,3'‐Bicarbazoles and Indolocarbazoles by Using Visible Light

2022

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A synthetic and mechanistic study of novel iterative double cyclization intramolecular S RN 1 reactions from diarylamines bearing two aryl halide moieties was carried out. This cyclization affords symmetric and unsymmetric 3,3'-bicarbazoles and indolocarbazoles compounds in regular to very good yields. The synthetic strategy employed for their preparation was a Buchwald-Hartwig arylation of anilines followed by an intra-molecular S RN 1 reaction, in the presence of base and visible light, at room temperature. The mechanism is non-trivial and it was studied using spectroscopy and computational calculations, employing the DFT method, with B3LYP and M06-2X functionals and 6-31 + G*, def2SVP and def2TZVP as bases and radicals are proposed as intermediates.

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Section: Characterization Data Of Compounds 5 Andmentioning

confidence: 99%

“…). FTIR (cm (19), 339 (11), 337 (11), 258 (46), 257 (18), 256 (20), 168 (15), 167 (100), 166 (40), 129 (35), 128 (47). FTIR (cm…”

Section: Characterization Data Of Compounds 5 Andmentioning

confidence: 99%

Section: Characterization Data Of Compounds 5 Andunclassified

Section: Characterization Data Of Compounds 5 Andmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Construction of 3,3'‐Bicarbazoles and Indolocarbazoles by Using Visible Light

2022

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Metal‐Free One‐Pot Synthesis of Tri‐ and Difluoromethylated Bis(carbazolyl)methanes

Miao

et al. 2022

Adv Synth Catal

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A Minireview on the Scope of Cadogan Cyclization Reactions Leading to Diverse Azaheterocycles

Kaur

Kumar

2022

Asian J Org Chem

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From the last two decades, Cadogan cyclization reaction is considered as one of the best routes for the preparation of various azaheterocycles comprising carbazoles, indoles, coumarins, carbolines, pyrazoloquinoxalines, S,N‐heterotetracenes from the nitro‐based substrates by using a variety of tetravalent phosphorus‐based reagents. To date the majority of Cadogan reactions are found to be intramolecular reactions, however, interestingly, a case of intermolecular Cadogan reaction is also reported, resulting in the widening of the reaction scope for futuristic perspectives. We report the Cadogan cyclization reactions for the synthesis of azaheterocycles from 2018 to present according to multiple classes of chemical frameworks including its scope (FDA approved drugs), along with the possibilities and mechanistic developments for unexpected products.

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Current status of carbazole hybrids as anticancer agents

Cited by 38 publications

References 105 publications

Construction of 3,3'‐Bicarbazoles and Indolocarbazoles by Using Visible Light

Construction of 3,3'‐Bicarbazoles and Indolocarbazoles by Using Visible Light

Metal‐Free One‐Pot Synthesis of Tri‐ and Difluoromethylated Bis(carbazolyl)methanes

A Minireview on the Scope of Cadogan Cyclization Reactions Leading to Diverse Azaheterocycles

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