Current status, and the developments of hosts and expression systems for the production of recombinant human cytokines

Das, Prabir Kumar; Sahoo, Ansuman; Dasu, Veeranki Venkata

doi:10.1016/j.biotechadv.2022.107969

Cited by 8 publications

(2 citation statements)

References 157 publications

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“…Previous studies reported that the CD44 Low CD62 Low T cells might act as pre‐effector‐like T cells, which had the resistance potential in the anti‐tumor therapy of PD‐1 blockade. [ 68 ] As the cytokine level is a typical indication of immune responses, [ 69,70 ] the variations of cytokines (e.g., TNF‐α and IFN‐γ) in the serum of different mouse groups were determined. In comparison with the control group, all the treatment groups showed significantly higher concentrations of TNF‐α and INF‐γ (Figure 6f).…”

Section: Resultsmentioning

confidence: 99%

Oral Nanomotor‐Enabled Mucus Traverse and Tumor Penetration for Targeted Chemo‐Sono‐Immunotherapy against Colon Cancer

Cao

Liu

et al. 2022

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The therapeutic outcomes of oral nanomedicines against colon cancer are heavily compromised by their lack of specific penetration into the internal tumor, favorable anti‐tumor activity, and activation of anti‐tumor immunity. Herein, hydrogen peroxide (H2O2)/ultrasound (US)‐driven mesoporous manganese oxide (MnOx)‐based nanomotors are constructed by loading mitochondrial sonosensitizers into their mesoporous channels and orderly dual‐functionalizing their surface with silk fibroin and chondroitin sulfate. The locomotory activities and tumor‐targeting capacities of the resultant nanomotors (CS‐ID@NMs) are greatly improved in the presence of H2O2 and US irradiation, inducing efficient mucus‐traversing and deep tumor penetration. The excess H2O2 in the tumor microenvironment (TME) is decomposed into hydroxyl radicals and oxygen by an Mn2+‐mediated Fenton‐like reaction, and the produced oxygen participates in sonodynamic therapy (SDT), yielding abundant singlet oxygen. The combined Mn2+‐mediated chemodynamic therapy and SDT cause effective ferropotosis of tumor cells and accelerate the release of tumor antigens. Importantly, animal experiments reveal that the treatment of combining oral hydrogel (chitosan/alginate)‐embedding CS‐ID@NMs and immune checkpoint inhibitors can simultaneously suppress the growth of primary and distal tumors through direct killing, reversion of immunosuppressive TME, and potentiation of systemic anti‐tumor immunity, demonstrating that the CS‐ID@NM‐based platform is a robust oral system for synergistic treatment of colon cancer.

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Section: Resultsmentioning

confidence: 99%

Oral Nanomotor‐Enabled Mucus Traverse and Tumor Penetration for Targeted Chemo‐Sono‐Immunotherapy against Colon Cancer

Cao

Liu

et al. 2022

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“…A variety of cytokines participate in the coordination of the immune system and respond to endogenous or exogenous stimuli (34)(35)(36). Previous studies have showed that CP derived from enzymatic hydrolysate of Salmo salar skin had antiinflammatory effects in LPS-induced Raw264.7 cell model (37).…”

Section: Discussionmentioning

confidence: 99%

Collagen peptide promotes DSS-induced colitis by disturbing gut microbiota and regulation of macrophage polarization

Cui²,

Feng³

et al. 2022

Front. Nutr.

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Ulcerative colitis (UC) is an inflammatory bowel disease caused by mucosal immune system disorder, which has increased steadily all over the world. Previous studies have shown that collagen peptide (CP) has various beneficial biological activities, it is not clear whether the effect of CP on UC is positive or negative. In this study, 2.5% dextran sulfate sodium (DSS) was used to establish acute colitis in mice. Our results suggested that CP supplementation (200, 400 mg/kg/day) promoted the progression of colitis, increased the expression of inflammatory factors and the infiltration of colonic lamina propria macrophages. Gut microbiota analysis showed the composition changed significantly and inflammation promoted bacteria was after CP treatment. Meanwhile, the effect of CP on macrophage polarization was further determined in Raw264.7 cell line. The results showed that CP treatment could increase the polarization of M1 macrophages and promote the expression of inflammatory factors. In conclusion, our results showed that CP treatment could disrupt the gut microbiota of host, promote macrophage activation and aggravate DSS-induced colitis. This may suggest that patients with intestinal inflammation should not take marine derived CP.

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Optimization of Recombinant Protein Production in Synechococcus elongatus PCC 7942: Utilizing Native Promoters and Magnetic Fields

Cardoso,

Azevedo,

Brum

et al. 2024

Curr Microbiol

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Current status, and the developments of hosts and expression systems for the production of recombinant human cytokines

Cited by 8 publications

References 157 publications

Oral Nanomotor‐Enabled Mucus Traverse and Tumor Penetration for Targeted Chemo‐Sono‐Immunotherapy against Colon Cancer

Oral Nanomotor‐Enabled Mucus Traverse and Tumor Penetration for Targeted Chemo‐Sono‐Immunotherapy against Colon Cancer

Collagen peptide promotes DSS-induced colitis by disturbing gut microbiota and regulation of macrophage polarization

Optimization of Recombinant Protein Production in Synechococcus elongatus PCC 7942: Utilizing Native Promoters and Magnetic Fields

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