Current Status and Outlook of Porous Zn-based Scaffolds for Bone Applications: A Review

Yusop, Abdul Hakim Md; Ulum, Mokhamad Fakhrul; Sakkaf, Ahmed Al; Nur, Hadi

doi:10.1007/s42235-022-00152-w

Cited by 8 publications

(4 citation statements)

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“…There have been vast reports on the use of biodegradable metals for bone temporary medical scaffold applications in the last decade. Iron (Fe), [ 1 ] magnesium (Mg), [ 2 ] zinc (Zn) [ 3 ] and their alloys are the current three biodegradable metals members that have been rigorously explored as they possess different corrosion behavior, mechanical properties, and biocompatibility. [ 4 ] In comparison to the Mg‐based and Zn‐based materials, Fe‐based materials have superior mechanical properties such as yield strength [ 5 ] and modulus of elasticity in addition to their favorable ductility and formability.…”

Section: Introductionmentioning

confidence: 99%

“…Iron (Fe), [ 1 ] magnesium (Mg), [ 2 ] zinc (Zn) [ 3 ] and their alloys are the current three biodegradable metals members that have been rigorously explored as they possess different corrosion behavior, mechanical properties, and biocompatibility. [ 4 ] In comparison to the Mg‐based and Zn‐based materials, Fe‐based materials have superior mechanical properties such as yield strength [ 5 ] and modulus of elasticity in addition to their favorable ductility and formability. [ 6 ] In spite of this, pure Fe has intrinsically an excessively low corrosion rate that could not match the rate of bone tissue regeneration.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of in vitro corrosion behavior and biocompatibility of poly[xylitol‐(1,12‐dodecanedioate)](PXDD)‐HA coated porous iron for bone scaffolds applications

Md Yusop,

Wan Ali,

Jamaludin

et al. 2024

Biotechnology Journal

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The present study evaluates the corrosion behavior of poly[xylitol‐(1,12‐dodecanedioate)](PXDD)‐HA coated porous iron (PXDD140/HA‐Fe) and its cell‐material interaction aimed for temporary bone scaffold applications. The physicochemical analyses show that the addition of 20 wt.% HA into the PXDD polymers leads to a higher crystallinity and lower surface roughness. The corrosion assessments of the PXDD140/HA‐Fe evaluated by electrochemical methods and surface chemistry analysis indicate that HA decelerates Fe corrosion due to a lower hydrolysis rate following lower PXDD content and being more crystalline. The cell viability and cell death mode evaluations of the PXDD140/HA‐Fe exhibit favorable biocompatibility as compared to bare Fe and PXDD‐Fe scaffolds owing to HA's bioactive properties. Thus, the PXDD140/HA‐Fe scaffolds possess the potential to be used as a biodegradable bone implant.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of in vitro corrosion behavior and biocompatibility of poly[xylitol‐(1,12‐dodecanedioate)](PXDD)‐HA coated porous iron for bone scaffolds applications

Md Yusop,

Wan Ali,

Jamaludin

et al. 2024

Biotechnology Journal

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“… 15 A number of zinc-based scaffolds have been reported to be used in medicinal chemistry for a longer period of time as therapeutic moieties. 16 These metal scaffold derivatives were applied for treatment of cancerous diseases to recover from inflammation, for the management of diabetes mellitus and microbial diseases, and in the therapy of specific conditions, such as Huntington’s disease, heart diseases, and genetic diseases, among others. The use of metal complexes as an effective therapeutic entity shows that it is possible to minimize toxicity at the cellular level by selecting a suitable ligand.…”

Section: Introductionmentioning

confidence: 99%

“…Zinc, copper, and iron have been found with improved pharmacological importance in our body, and lack of any one of these can lead to decreased immunity and development of bizarre and diminished ability of a person toward a normal body working . A number of zinc-based scaffolds have been reported to be used in medicinal chemistry for a longer period of time as therapeutic moieties . These metal scaffold derivatives were applied for treatment of cancerous diseases to recover from inflammation, for the management of diabetes mellitus and microbial diseases, and in the therapy of specific conditions, such as Huntington’s disease, heart diseases, and genetic diseases, among others.…”

Section: Introductionmentioning

confidence: 99%

Prospective Evaluation of an Amide-Based Zinc Scaffold as an Anti-Alzheimer Agent: In Vitro, In Vivo, and Computational Studies

et al. 2022

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Alzheimer’s disease is the most common progressive neurodegenerative mental disorder associated with loss of memory, decline in cognitive function, and dysfunction of language. The prominent pathogenic causes of this disease involve deposition of amyloid-β plaques, acetylcholine neurotransmitter deficiency, and accumulation of neurofibrillary tangles. There are multiple pathways that have been targeted to treat this disease. The inhibition of the intracellular cyclic AMP regulator phosphodiesterase IV causes the increase in CAMP levels that play an important role in the memory formation process. Organometallic chemistry works in a different way in treating pharmacological disorders. In the field of medicinal chemistry and pharmaceuticals, zinc-based amide carboxylates have been shown to be a preferred pharmacophore. The purpose of this research work was to investigate the potential of zinc amide carboxylates in inhibition of phosphodiesterase IV for the Alzheimer’s disease management. Swiss Albino mice under controlled conditions were divided into seven groups with 10 mice each. Group I was injected with carboxymethylcellulose (CMC) at 1 mL/100 g dose, group II was injected with Streptozotocin (STZ) at 3 mg/kg dose, group III was injected with Piracetam acting as a standard drug at 200 mg/kg dosage, while groups IV–VII were injected with a zinc scaffold at the dose regimen of 10, 20, 40, and 80 mg/kg through intraperitoneal injection. All groups except group I were injected with Streptozotocin on the first day and third day of treatment at the dose of 3 mg/kg through an intracerebroventricular route to induce Alzheimer’s disease. Afterward, respective treatment was continued for all groups for 23 days. In between the treatment regimen, groups were analyzed for memory and learning improvement through various behavioral tests such as open field, elevated plus maze, Morris water maze, and passive avoidance tests. At the end of the study, different biochemical markers in the brain were estimated like neurotransmitters (dopamine, serotonin and adrenaline), oxidative stress markers (superoxide dismutase, glutathione, and catalase), acetylcholinesterase (AchE), tau proteins, and amyloid-β levels. A PCR study was also performed. Results showed that the LD 50 of the zinc scaffold is greater than 2000 mg/kg. Research indicated that the zinc scaffold has the potential to improve the memory impairment and learning behavior in Alzheimer’s disease animal models in a dose-dependent manner. At the dose of 80 mg/kg, a maximum response was observed for the zinc scaffold. Maximum reduction in the acetylcholinesterase enzyme was observed at 80 mg/kg dose, which was further strengthened and verified by the PCR study. Oxidative stress was restored by the zinc scaffold due to the significant activation of the endogenous antioxidant enzymes. This research ended up with the conclusion that the zinc-based amide carboxylate scaffold has the potential to improve behavioral disturbances and vary the biochemica...

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Mechanical and Degradation Behavior of Zinc‐Based Biodegradable Metal Foams

Kádár,

Gorejová,

Kubelka

et al. 2024

Adv Eng Mater

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Zinc has gained interest as a biodegradable material due to its adequate degradation behavior under physiological conditions and acceptable biocompatibility. However, during the use of zinc as a degradable orthopedical implant, the mechanical properties are expected to change while the implant needs to maintain its function and mechanical support for 12‐24 months, with the load gradually transferred from the degrading implant to the healing bone. For such investigation, six different kinds of open‐cell zinc foams are fabricated by a modified investment casting method displaying different pore densities and strut thicknesses. Compressive properties and corrosion behavior in simulated body fluids are studied to determine the map of the most relevant parameters that influence the degradation properties. After 4 weeks of immersion in Hank’s solution, changes in the slope in the “plateau” region and strain localization are observed. These changes can be explained by supposing microcrack propagation into the depth of the struts due to the progressing corrosion attack.This article is protected by copyright. All rights reserved.

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Current Status and Outlook of Porous Zn-based Scaffolds for Bone Applications: A Review

Cited by 8 publications

References 97 publications

Evaluation of in vitro corrosion behavior and biocompatibility of poly[xylitol‐(1,12‐dodecanedioate)](PXDD)‐HA coated porous iron for bone scaffolds applications

Evaluation of in vitro corrosion behavior and biocompatibility of poly[xylitol‐(1,12‐dodecanedioate)](PXDD)‐HA coated porous iron for bone scaffolds applications

Prospective Evaluation of an Amide-Based Zinc Scaffold as an Anti-Alzheimer Agent: In Vitro, In Vivo, and Computational Studies

Mechanical and Degradation Behavior of Zinc‐Based Biodegradable Metal Foams

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