Current status and future direction of duck hepatitis A virus vaccines

Zhang, Yanyan; Wu, Shuang; Liu, Wenbo; Hu, Zenglei

doi:10.1080/03079457.2022.2162367

Cited by 9 publications

(6 citation statements)

References 76 publications

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“…Finally, the obtained results indicated that there is no cross immunization between DHAV-1 and DHAV-3. Therefore, an optimal protection could be achieved by including the two DHAV genotypes (1 and 3) (27).…”

Section: Discussionmentioning

confidence: 99%

Protective Efficacy of a Locally Prepared Bivalent Duck Viral Hepatitis “Serotypes 1 and 3” Inactivated Vaccine

Omar,

Abdrabo,

Monir

et al. 2024

Macedonian Veterinary Review

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The spread of duck hepatitis virus (DHV) in Egypt with its’ most prevalent genotypes (1 and 3) causes vast economic losses in the duck industry despite the regular vaccination with live attenuated vaccines. However, the use of live-vaccines is considered a potential risk for the non-vaccinated birds due to the viral shedding from vaccinated populations. The current study aimed to evaluate the protective efficacy and safety of two inactivated monovalent and one bivalent vaccines against DHV 1 and 3 genotypes. The inactivated monovalent (DHAV-1, DHAV-3) and bivalent (DHAV-1+3) vaccines were produced by using Montanide ISA 70 oil as an adjuvant. Three groups of 4-week-old ducklings (n=50) were vaccinated with one of the three vaccines, respectively. One group of ducklings was used as negative control (n=25). The immune-response of the vaccinated groups was measured by Virus Neutralization Test and expressed with Neutralizing Indices (NIs). The NIs for the bivalent vaccine group (5.6 and 5.4) were higher compared to the monovalent vaccine groups (5.0 and 4.7). In conclusion, the use of inactivated bivalent DHV vaccine could produce higher protective efficacy compared to the monovalent DHAV-1 and DHAV-3 vaccines.

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Section: Discussionmentioning

confidence: 99%

Protective Efficacy of a Locally Prepared Bivalent Duck Viral Hepatitis “Serotypes 1 and 3” Inactivated Vaccine

Omar,

Abdrabo,

Monir

et al. 2024

Macedonian Veterinary Review

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“…On the other hand, adult ducks typically exhibit resistance to DHAV and do not show apparent clinical symptoms upon infection. However, the infected adult ducks can still shed the virus, serving as a potential source of infection for others [ 6 ]. However, a recent study has reported that a DHAV-1 infection can potentially trigger egg drop syndrome [ 72 , 73 ].…”

Section: Discussionmentioning

confidence: 99%

“…However, there are also several duck vertical transmission viral diseases that are often overlooked, including duck hepatitis B virus (DHBV), duck circovirus (DuCV), duck hepatitis A virus (DHAV), and avian reoviruses (ARV). These diseases can pose health risks to the duck industry, leading to problems such as duckling deformities, increased mortality rates, and poor growth and development [ 2 , 3 , 4 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Molecular Detection and Genetic Characterization of Vertically Transmitted Viruses in Ducks

Wang,

Yu,

Zhang

et al. 2023

Animals

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To investigate the distribution and genetic variation in four vertically transmitted duck pathogens, including duck hepatitis B virus (DHBV), duck circovirus (DuCV), duck hepatitis A virus 3 (DHAV-3), and avian reoviruses (ARV), we conducted an epidemiology study using PCR and RT-PCR assays on a duck population. We found that DHBV was the most prevalent virus (69.74%), followed by DuCV (39.48%), and then ARV (19.92%) and DHAV-3 (8.49%). Among the 271 duck samples, two, three or four viruses were detected in the same samples, indicating that the coinfection of vertical transmission agents is common in ducks. The genetic analysis results showed that all four identified DuCV strains belonged to genotype 1, the DHAV-3 strain was closely clustered with previously identified strains from China, and the ARV stain was clustered under genotype 1. These indicate that different viral strains are circulating among the ducks. Our findings will improve the knowledge of the evolution of DuCV, DHAV-3, and ARV, and help choose suitable strains for vaccination.

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“…The vaccines for DHAV-3 prevention are actually limited to the lab setting, and there is currently no licensed vaccine for the mass market [ 32 , 35 ]. So efforts should be taken to develop novel DHAV-3 vaccines [ 36 ]. Meanwhile, clinical mass samples should be expanded to test the protective effect of DHAV in clinical cases more objectively and effectively.…”

Section: Discussionmentioning

confidence: 99%

A meta-analysis for vaccine protection rate of duck hepatitis a virus in mainland China in 2009–2021

Ye,

Zhou,

Zhang

et al. 2023

BMC Vet Res

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Background Duck hepatitis A virus (DHAV) is a single-stranded, positive-strand small RNA virus that causes a very high mortality rate in ducklings. The DHAV-3 subtype incidence rate has recently increased in China, causing great economic losses to the waterfowl breeding industry. We analyzed the protection rate of DHAV vaccines used in mainland China from 2009 to 2021 and evaluated the effectiveness of vaccine prevention and control to reduce the economic losses caused by DHAV to the waterfowl breeding industry. We screened five electronic research databases and obtained 14 studies and patents on the protection efficiency of DHAV-1 and DHAV-3 vaccines. Results Meta-analysis demonstrated that immunized ducklings produced higher antibody levels and had a significantly higher survival rate than non-immunized ducklings [relative risk (RR) = 12, 95% confidence interval (CI) 6–26, P < 0.01]. The age of the ducks and vaccine valence did not affect protection efficiency. Data source analysis of the vaccine protection rate demonstrated that the vaccines conferred immune protection for ducklings in both small-scale experiments and large-scale clinical conditions. The analysis results revealed that although the vaccines conferred protection, the immune protective effect differed between small-scale experimental conditions and large-scale clinical conditions. This might have been due to non-standard vaccination and environmental factors. Conclusions Domestic DHAV vaccines can protect ducklings effectively. The subjects immunized (breeding ducks or ducklings) and vaccine valence had no effect on the protective effect. Both small-scale experiments and large-scale clinical conditions conferred immune protection on ducklings, but vaccine immunization under small-scale experimental conditions had slightly better protective effects than large-scale clinical immunization.

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Current status and future direction of duck hepatitis A virus vaccines

Cited by 9 publications

References 76 publications

Protective Efficacy of a Locally Prepared Bivalent Duck Viral Hepatitis “Serotypes 1 and 3” Inactivated Vaccine

Protective Efficacy of a Locally Prepared Bivalent Duck Viral Hepatitis “Serotypes 1 and 3” Inactivated Vaccine

Molecular Detection and Genetic Characterization of Vertically Transmitted Viruses in Ducks

A meta-analysis for vaccine protection rate of duck hepatitis a virus in mainland China in 2009–2021

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