Current State of Knowledge on Salivary Gland Cancers

Lin, H. Helen; Limesand, Kirsten H.; Ann, David K.

doi:10.1615/critrevoncog.2018027598

Cited by 58 publications

(68 citation statements)

References 99 publications

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“…The epidemiological findings of our study are relatively consistent with those in the existing literature. The majority of our patients were male and over the age of 50 years which is similar to previous studies (5)(6)(7)(8) {Lin, 2018 #170}. Cancers of the salivary glands are classified broadly as arising from either one of the major salivary or minor salivary glands.…”

Section: Discussionsupporting

confidence: 83%

Malignant Salivary Gland Tumours - a single centre experience

Malik

Devabalan

Bernstein

et al. 2020

Preprint

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Objectives: Salivary gland malignancies are an uncommon and heterogeneous group of cancers. We report our experience of clinicopathological variables that affect survival in patients treated by curative intent with surgery at a UK institution over a period of 15 years. Design: Retrospective cohort study Setting: Single centre study Participants We included 108 patients with malignant salivary gland tumours treated by curative intent with surgery from 2004 to 2019. Main outcome measures: The association between clinicopathological factors and their impact on overall survival (OS) and disease-free survival (DFS). Results: 77 (71.3%) presented with early pT classification and 81 (75%) of were node-negative. The parotid was the commonest site of malignancy (86, 79.6%). Perineural invasion (PNI) was present in 40 (37%) and lymphovascular invasion (LVI) was present in 20 (18.5%). 63 (58.3%) underwent adjuvant therapy. Median follow up was 36 months. Five-year OS and DFS were 81.7% and 71%. Age ?50, pT classification 3-4, high tumour grade, PNI, and advanced TNM stage were all associated with worse OS and DFS, and LVI with worse DFS. There was no survival difference between a close (1-<5 mm) or negative ([?]5 mm) resection margin. Conclusions: Age >50 years, advanced TNM stage, PNI and LVI are predictors of poor DFS. There was no difference in OS or DFS between patients with negative and close resection margins, indicating that close margins may be adequate for maintaining good oncologic outcomes in this group of patients.

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Section: Discussionsupporting

confidence: 83%

Malignant Salivary Gland Tumours - a single centre experience

Malik

Devabalan

Bernstein

et al. 2020

Preprint

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“…Incidence rates have similarly been reported as 1.31/100.000 in Europe and as 1.04/100.000 in Japan [4]. These tumors increase, especially after the age of 50, and their incidence increases to above 7/100.000 at the age of 70 [3]. They can be seen in both sexes.…”

mentioning

confidence: 71%

“…dence has been reported as 1.1-1.3/100.000 annually in the United States [3]. Incidence rates have similarly been reported as 1.31/100.000 in Europe and as 1.04/100.000 in Japan [4].…”

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confidence: 97%

Salivary gland tumors: a 15-year experience of a universıty hospital in Turkey

Mengi

Kara

Tümkaya

et al. 2020

North Clin Istanbul

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T he salivary glands consist of three major glands as parotid, submandibular and sublingual glands and hundreds of minor glands, which are diffusely located in the beginning part of the respiratory system. Tumors of the salivary glands are rarely encountered. However, they appear with different histopathological characters. Different biological behaviors can be observed even in neoplasms defined by the same name. In the latest classification made by the World Health Organization (WHO) in 2017, salivary gland tumors were classified into more than 30 benign and malignant histologic subtypes [1]. This wide histopathological spectrum and significant differences in prognosis between them distinguish salivary gland tumors from other organ neoplasms. Salivary gland tumors account for approximately 3-4% of all head and neck tumors [2]. Their inci-ABSTRACT OBJECTIVE: To determine the demographic characteristics of benign and malignant salivary gland tumors in our department in the last 15 years. METHODS: In this study, the files of the patients who underwent salivary gland surgery between 2004 and 2019 in our department were analyzed retrospectively. A total of 366 patients whose diagnoses of salivary gland tumor histopathologically confirmed were included in this study. The demographic data of the patients and tumor localizations were recorded, and their relationships with histopathological results were examined. RESULTS: Of the 366 tumors, 292 (80%) of them was originated from the parotid gland, 52 (14%) from the submandibular gland, and 22 (6%) from the minor salivary gland. The male: female ratio was found as 1.2:1, and the mean age of the patients was 50.37 years. A total of 259 (70.8%) tumors were benign, and 107 (29.2%) were malignant. The most frequent benign tumor was pleomorphic adenoma, with 121 cases (46.7%). While pleomorphic adenomas constituted the majority of the benign tumors of the submandibular gland and minor salivary glands, Warthin tumor was detected more than pleomorphic adenoma in the parotid gland. The most common malignant tumor was mucoepidermoid carcinoma, with 26 cases (24.3%). CONCLUSION: The distribution of the salivary gland tumors detected in our department was found to be substantially similar to other worldwide series. Unlike the literature, we concluded that salivary gland tumors were seen slightly more in males, minor salivary gland tumors were relatively rare and Warthin tumors were more frequently detected in our region.

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“…Characterized by slow growth kinetics and perineural invasion, it is one of the most common histologic types of salivary malignancy, comprising 34% to 69% of primary salivary tumors. [3][4][5] Some reports in the literature indicate that these tumors will present in more advanced stages than other laryngeal malignancies. [6][7][8] Although AdCC has been reported to present in later stages, the current literature is lacking regarding incidence, outcomes, and survival of AdCC as it relates to the larynx.…”

Section: Introductionmentioning

confidence: 99%

Adenoid Cystic Carcinoma of the Larynx: A SEER Database Review

et al. 2020

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Background: Adenoid cystic carcinoma (AdCC) of the larynx is an uncommon malignancy of the head and neck with very little literature discussing treatment paradigms and prognostic factors influencing survival. Methods: This retrospective cohort study uses data obtained from the Surveillance, Epidemiology and End Result database comprising of patients diagnosed with laryngeal AdCC from 1978 to 2016. Results: A total of 89 records were analyzed. High histologic grade was a significant negative prognostic factor compared to low histologic grade disease for overall survival (OS; 5-year OS: 35.7% vs 90.5%, P < .005) and disease-specific survival (DSS; 5-year DSS: 38.7% vs 95.2%, P < .005). No differences in OS (5-year OS: 88.9% vs 76.4%, P = .287) or DSS (5-year DSS: 100% vs 79.1%, P = .159) were noted between patients with early versus late American Joint Committee on Cancer (AJCC) stage disease. No differences in DSS was noted in cohorts treated with just definitive surgery versus surgery and adjuvant radiation (5-year DSS: 92.9% vs 74.3%, P = .140) even when stratified for late stage disease (5-year DSS: 100% vs 78.6%, P = .290) or high-grade histology (5-year DSS: 100% vs 83.3%, P = .773). Conclusions: Histologic grade may be a more significant prognostic factor than AJCC stage for survival in laryngeal AdCC. Treatment with surgery and radiation may provide no additional survival advantage compared to just definitive surgery in these patients, although further study is warranted.

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Current State of Knowledge on Salivary Gland Cancers

Cited by 58 publications

References 99 publications

Malignant Salivary Gland Tumours - a single centre experience

Malignant Salivary Gland Tumours - a single centre experience

Salivary gland tumors: a 15-year experience of a universıty hospital in Turkey

Adenoid Cystic Carcinoma of the Larynx: A SEER Database Review

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