Adenoid Cystic Carcinoma of the Larynx: A SEER Database Review

Abstract

Background: Adenoid cystic carcinoma (AdCC) of the larynx is an uncommon malignancy of the head and neck with very little literature discussing treatment paradigms and prognostic factors influencing survival. Methods: This retrospective cohort study uses data obtained from the Surveillance, Epidemiology and End Result database comprising of patients diagnosed with laryngeal AdCC from 1978 to 2016. Results: A total of 89 records were analyzed. High histologic grade was a significant negative prognostic factor compared to low histologic grade disease for overall survival (OS; 5-year OS: 35.7% vs 90.5%, P < .005) and disease-specific survival (DSS; 5-year DSS: 38.7% vs 95.2%, P < .005). No differences in OS (5-year OS: 88.9% vs 76.4%, P = .287) or DSS (5-year DSS: 100% vs 79.1%, P = .159) were noted between patients with early versus late American Joint Committee on Cancer (AJCC) stage disease. No differences in DSS was noted in cohorts treated with just definitive surgery versus surgery and adjuvant radiation (5-year DSS: 92.9% vs 74.3%, P = .140) even when stratified for late stage disease (5-year DSS: 100% vs 78.6%, P = .290) or high-grade histology (5-year DSS: 100% vs 83.3%, P = .773). Conclusions: Histologic grade may be a more significant prognostic factor than AJCC stage for survival in laryngeal AdCC. Treatment with surgery and radiation may provide no additional survival advantage compared to just definitive surgery in these patients, although further study is warranted.

Prognostic effects of surgery or radiotherapy on adenoid cystic carcinoma of the head and neck: a retrospective cohort study

“…However, another study has shown post-operative radiotherapy has no significant effect on the prognosis of ACC patients. A review by Mur et al identified that the 5-year disease-specific survival of patients with ACC of the larynx was 92.9% in those receiving surgery alone and 74.3% in those receiving surgery and radiotherapy, but no significant difference in survival was found among those receiving both surgery and radiotherapy ( 27 ). Lloyd et al found that post-operation radiotherapy does not significantly affect the survival outcomes of patients ( 28 ).…”

Highly sensitive detection of CYFRA21-1 with a SERS sensing platform based on the MBs enrichment strategy and antibody-DNA-mediated CHA amplification

“…The 5-year relative survival rate for patients with LC varies widely according to tumor site and stage. However, it should be noted that the 5-year survival rate of LC has been proved to decline gradually over the past 40 years, from 66% to 63% since most patients have developed to the middle and late stages by the time they are diagnosed, missing the best treatment period ( Ono et al, 2020 ; Miskiewicz-Orczyk et al, 2021 ; Mur et al, 2022 ; Zhou et al, 2022 ). Therefore, early detection, diagnosis and treatment are crucial to improve the prognosis of LC.…”