Current state of fabrication technologies and materials for bone tissue engineering

Wubneh, Abiy; Tsekoura, Eleni K.; Ayranci, Cagri; Uludağ, Hasan

doi:10.1016/j.actbio.2018.09.031

Cited by 449 publications

(313 citation statements)

References 302 publications

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“…33 In most circumstances, the realization of orderly hierarchical scaffolds depends on a combination of different methods, rather than on a single technology. 34 Herein, we summarize common methods for fabricating scaffolds with hierarchical structures for bone repair, and review recent progress in this field.…”

Section: Fabrication Of Three-dimensional Biomaterials Scaffolds For Bmentioning

confidence: 99%

Effect of the nano/microscale structure of biomaterial scaffolds on bone regeneration

2020

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Natural bone is a mineralized biological material, which serves a supportive and protective framework for the body, stores minerals for metabolism, and produces blood cells nourishing the body. Normally, bone has an innate capacity to heal from damage. However, massive bone defects due to traumatic injury, tumor resection, or congenital diseases pose a great challenge to reconstructive surgery. Scaffold-based tissue engineering (TE) is a promising strategy for bone regenerative medicine, because biomaterial scaffolds show advanced mechanical properties and a good degradation profile, as well as the feasibility of controlled release of growth and differentiation factors or immobilizing them on the material surface. Additionally, the defined structure of biomaterial scaffolds, as a kind of mechanical cue, can influence cell behaviors, modulate local microenvironment and control key features at the molecular and cellular levels. Recently, nano/micro-assisted regenerative medicine becomes a promising application of TE for the reconstruction of bone defects. For this reason, it is necessary for us to have in-depth knowledge of the development of novel nano/micro-based biomaterial scaffolds. Thus, we herein review the hierarchical structure of bone, and the potential application of nano/micro technologies to guide the design of novel biomaterial structures for bone repair and regeneration.

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Section: Fabrication Of Three-dimensional Biomaterials Scaffolds For Bmentioning

confidence: 99%

Effect of the nano/microscale structure of biomaterial scaffolds on bone regeneration

2020

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“…The main advantage of 3D printing is direct control over both the microarchitecture and complex anatomical structure. These 3D printed models allow the manufacture of customized scaffolds that mimics the patient's anatomy (Wubneh et al, 2018). However, there are different challenges in the translation of 3D printing bioceramics to clinical application.…”

Section: D Printing In Bone Tissue Engineering Applicationsmentioning

confidence: 99%

Reconstruction of Large Skeletal Defects: Current Clinical Therapeutic Strategies and Future Directions Using 3D Printing

Vidal

Kampleitner

Brennan

et al. 2020

Front. Bioeng. Biotechnol.

136

108

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The healing of bone fractures is a well-orchestrated physiological process involving multiple cell types and signaling molecules interacting at the fracture site to replace and repair bone tissue without scar formation. However, when the lesion is too large, normal healing is compromised. These so-called non-union bone fractures, mostly arising due to trauma, tumor resection or disease, represent a major therapeutic challenge for orthopedic and reconstructive surgeons. In this review, we firstly present the current commonly employed surgical strategies comprising auto-, allo-, and xenograft transplantations, as well as synthetic biomaterials. Further to this, we discuss the multiple factors influencing the effectiveness of the reconstructive therapy. One essential parameter is adequate vascularization that ensures the vitality of the bone grafts thereby supporting the regeneration process, however deficient vascularization presents a frequently encountered problem in current management strategies. To address this challenge, vascularized bone grafts, including free or pedicled fibula flaps, or in situ approaches using the Masquelet induced membrane, or the patient's body as a bioreactor, comprise feasible alternatives. Finally, we highlight future directions and novel strategies such as 3D printing and bioprinting which could overcome some of the current challenges in the field of bone defect reconstruction, with the benefit of fabricating personalized and vascularized scaffolds.

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“…Therefore, a reasonable implant structure should be porous to promote the transport of nutrients, oxygen, etc. Moreover, the porous structure has a large specific surface area, which facilitates cell adhesion and promotes vascularization [88]. For the high elastic modulus of the metal, the porous structure also reduces its modulus to fit the modulus of the bone.…”

Section: Topology Structure Designmentioning

confidence: 99%

Additive Manufacturing of Customized Metallic Orthopedic Implants: Materials, Structures, and Surface Modifications

Bai

Cheng

Chen

et al. 2019

Metals

121

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Metals have been used for orthopedic implants for a long time due to their excellent mechanical properties. With the rapid development of additive manufacturing (AM) technology, studying customized implants with complex microstructures for patients has become a trend of various bone defect repair. A superior customized implant should have good biocompatibility and mechanical properties matching the defect bone. To meet the performance requirements of implants, this paper introduces the biomedical metallic materials currently applied to orthopedic implants from the design to manufacture, elaborates the structure design and surface modification of the orthopedic implant. By selecting the appropriate implant material and processing method, optimizing the implant structure and modifying the surface can ensure the performance requirements of the implant. Finally, this paper discusses the future development trend of the orthopedic implant.

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Current state of fabrication technologies and materials for bone tissue engineering

Cited by 449 publications

References 302 publications

Effect of the nano/microscale structure of biomaterial scaffolds on bone regeneration

Effect of the nano/microscale structure of biomaterial scaffolds on bone regeneration

Reconstruction of Large Skeletal Defects: Current Clinical Therapeutic Strategies and Future Directions Using 3D Printing

Additive Manufacturing of Customized Metallic Orthopedic Implants: Materials, Structures, and Surface Modifications

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