Current role of local treatments for erectile dysfunction in the real-life setting

Abstract

Local treatments can have an important role as a first-line treatment for erectile dysfunction or in drug combinations mainly because of their excellent safety profile.

A comparative study of dialectical behavior therapy and aripiprazole on marital instability of in patients with hypersexual

“…[ 23 ] Aripiprazole has also been shown to reduce hospitalization in psychiatric hospitals, reduce the symptoms of late dyskinesia, improve cognitive function, improve sexual function, and reduce the desire for alcohol and sex in addicted patients. [ 11 ] Therefore, when a person with hypersexuality shows less excitability and impulsive behaviors, he/she will show less repetitive and aimless actions, will improve cognitive functions, modulate sexual activities, and may compensate for defects in the sexual behaviors that a person has had with his/her spouse. The affected person and the couple show more hope in life regarding positive changes they have experienced through Aripiprazole in their lives, thus expecting improvement in marital relationships and quality of life, resulting in more stable relationships.…”

“…Despite their relative effectiveness, some medical interventions, such as the use of Selective Serotonin Reuptake Inhibitors (SSRIs), antiandrogens, and other standard and well-known psychiatric medications, are used for these disorders. [ 9 10 11 ] Aripiprazole is an antipsychotic drug and a partial agonist of dopamine D2 receptor agonist, rarely associated with sexual side effects. Sexual disorder is a significant reason for nonadherence to antipsychotic drugs in patients with mental health disorders.…”

Erectile Dysfunction: Treatments, Advances and New Therapeutic Strategies

“…Similar results are obtained with other α 1 -adrenergic receptor antagonists, such as phenoxybenzamine and moxisylite [42], but phentolamine is the only α 1 -adrenergic receptor antagonist used in the intracavernous therapy of ED, usually in combination with other drugs (i.e., prostaglandin E1, alprostadil and/or papaverine) [105] (see below). However, even when given intracavernously, this drug often produces orthostatic hypotension, tachycardia and, although rarely, also priapism [106,107]. These effects (except priapism) are usually seen with α 1 -adrenergic receptor antagonists given systemically and have been used for a long time as a monotherapy for the control of idiopathic hypertension, benign prostatic hyperplasia and associated bladder neck obstruction, voiding and storage, which also induce alterations in sexual, mainly ejaculatory function [108].…”

“…The blockade of these enzymes by drugs injected intracavernously, such as papaverine, induces penile erection. The intracavernous injection of a combination of prostaglandin E1, phentolamine and papaverine is the most common therapy for the local treatment of ED and is usually used when oral PDe5 inhibitors are found to be inefficacious [105,[107][108][109][110][111][112].…”