Current Reperfusion Therapy Possibilities in Myocardial Infarction and Ischemic Stroke

Константинова, Е. В.; Шостак, Н. А.; Гиляров, М. Ю.

doi:10.17650/1818-8338-2015-1-4-12

Cited by 3 publications

(4 citation statements)

References 27 publications

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“…P. Karst. [3]. Later, these studies were continued on a wide mycological material, including cultures and fruiting bodies of basidiomycetes from various taxonomic and ecological groups [16].…”

Section: Use Of Proteases From Fungi and Bacteria As Thrombolytic Agentsmentioning

confidence: 99%

“…According to the statistics of the medical and prophylactic institution of the Administrative Department of the President of the Russian Federation, in the first 3 hours from the onset of an anginal attack, only 25% of patients are admitted to hospitals, and during the first 6 hours -50% of patients. Drug therapy with the use of thrombolytics allows to achieve early reperfusion, complete restoration of blood flow in the infarct-associated artery is possible in 60% of patients [3]. Open surgeries in neurology and neurosurgery are increasingly being replaced by minimally invasive interventions, which allow, while maintaining the radicality of hemorrhage removal, to improve the functional outcomes of the disease.…”

Section: Introductionmentioning

confidence: 99%

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Modern concepts of the fibrinolytic system

2020

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Among all medical pathologies, cardiovascular diseases are the most dangerous and deadly. On the one hand, thrombosis is a natural reaction of a person to damage to blood vessels, on the other hand, thrombosis is often the cause of death in the event of cardiovascular disease. There is a natural process called fibrinolysis to dissolve a blood clot after the bleeding has stopped and preventing vascular occlusion. This article examines current understanding of the human fibrinolytic system, main elements of fibrinolytic system and also addresses the topic of thrombolytic therapy.

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Section: Use Of Proteases From Fungi and Bacteria As Thrombolytic Agentsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Modern concepts of the fibrinolytic system

2020

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“…Без сомнения, фармакологическая и механическая реперфузия на ранних стадиях является единственным способом предотвратить прогрессирующий миокардиальный некроз и таким образом ограничить размер зоны инфаркта. Однако миокардиальное ИРП было описано после реперфузионных методов лечения, включая чрескожное коронарное вмешательство (ЧКВ), тромболизис и коронарное шунтирование [3,4,7]. Реперфузия сосудов была признана с появлением методов реканализации [49], однако ее патофизиологическое и прогностическое значение все еще содержит много вопросов [50].…”

Section: патологоанатомические аспекты в отношении ишемического и реперфузионного повреждения миокардаunclassified

“…Несмотря на это, вопрос о точных патофизиологических механизмах остается проблемой для клинических врачей [5,6]. Перевод результатов экспериментов кардиопротекции в клиническую практику имеет ряд трудностей, потому что клинические исследования на людях отличаются по некоторым параметрам от экспериментов над животными [7,8]. С учетом перечисленного реперфузионная терапия остается одним из важных этапов при защите миокарда.…”

Section: Introductionunclassified

Novel Aspects of Cardiac Ischemia and Reperfusion Injury Mechanisms

Yagudin

Shabanova

Liu

2019

Kreativnaâ hirurgiâ i onkologiâ

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Introduction.The present article, in which a contemporary analysis of the literature on the pathophysiology of ischemic and reperfusion injury (IRI) of the myocardium is presented, focuses on the possible role played by of the calpain system and oxidative stress. Several process development options were proposed, including cytosolic and mitochondrial Ca2+ overload, reactive oxygen stress release, acute inflammatory response and metabolic degradation. The combined effect of all of the above factors produces irreversible ischemic and reperfused damage of cardiomyocytes.Materials and methods.The role of the calpain system in the creation of myocardial IRI was experimentally investigated. It was found that active calpain substrates play a significant role in the processes of cell cycle, apoptosis and differentiation, adversely affecting cardiomyocyte functionality. The calpain system is part of an integrated proteolytic system that is critical to the relationship between the structure and function of the cardiac sarcomere. Uncontrolled activation of calpain is indicated in the pathophysiology of many cardiovascular disorders. As shown by research, inhibitor calpain reduces the size of the zone of infarction following ischemia reperfusion and thus lessens the risk of “stunning” the myocardium. As is known, a consequence of IRI is acute myocardial infarction (AMI), which is a central factor in cardiovascular disease (CVD) and is one of the primary causes of mortality. Understanding the exact pathophysiological mechanisms remains an urgent problem for clinical physicians. To date, the mechanisms of IRI are not fully known, which creates certain difficulties in further treatment and prevention tactics. In addition, myocardial IRI is also an important issue for pathoanatomical service, since sudden coronary death can occur despite timely reperfusion therapy following AMI.Conclusion.The development of strategies for creating conditions that limit the degree of damage to myocardial tissues significantly increases the ability of the heart to withstand ischemic damage.

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Prospects for developing and implementing remote blood pressure monitoring in patients under dispensary follow-up

Drapkina¹,

Korsunsky²,

Komkov

et al. 2022

Cardiovasc Ther Prev

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Recently, the use of telemedicine technologies (TMT) in the healthcare has gained great importance. TMT is one of the ways to increase the healthcare availability, including in patients with high blood pressure (BP). Office BP measurement and 24-hour BP monitoring are not accurate enough to study natural or induced BP changes over long periods of time. For the selection of antihypertensive drugs and the diagnosis of hypertension (HTN) in patients with an emotionally unstable personality type, as well as in the differential diagnosis of normotension, preHTN, BP selfmonitoring comes first. The use of BP self-monitoring for the diagnosis, selection of therapy, assessment of adherence and effectiveness of treatment of HTN is more effective with remote, socalled telemetric, dynamic BP monitoring. The article presents world experience in the effective use of dynamic remote BP monitoring using TMT.

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Current Reperfusion Therapy Possibilities in Myocardial Infarction and Ischemic Stroke

Cited by 3 publications

References 27 publications

Modern concepts of the fibrinolytic system

Modern concepts of the fibrinolytic system

Novel Aspects of Cardiac Ischemia and Reperfusion Injury Mechanisms

Prospects for developing and implementing remote blood pressure monitoring in patients under dispensary follow-up

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