Current prospects and challenges in fish vaccine development in India with special reference to Aeromonas hydrophila vaccine

Nayak, S.K.

doi:10.1016/j.fsi.2020.01.064

Cited by 52 publications

(28 citation statements)

References 89 publications

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“…Disease prevention in aquaculture species includes several strategies and management solutions, including vaccines and antibiotics. Vaccination is considered crucial as it is one of the main approaches to prevent and control diseases in aquaculture [ 16 ]. Currently, there are over 26 vaccines approved for a variety of fish species [ 6 , 17 , 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Bacteriophages in the Control of Aeromonas sp. in Aquaculture Systems: An Integrative View

et al. 2022

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Aeromonas species often cause disease in farmed fish and are responsible for causing significant economic losses worldwide. Although vaccination is the ideal method to prevent infectious diseases, there are still very few vaccines commercially available in the aquaculture field. Currently, aquaculture production relies heavily on antibiotics, contributing to the global issue of the emergence of antimicrobial-resistant bacteria and resistance genes. Therefore, it is essential to develop effective alternatives to antibiotics to reduce their use in aquaculture systems. Bacteriophage (or phage) therapy is a promising approach to control pathogenic bacteria in farmed fish that requires a heavy understanding of certain factors such as the selection of phages, the multiplicity of infection that produces the best bacterial inactivation, bacterial resistance, safety, the host’s immune response, administration route, phage stability and influence. This review focuses on the need to advance phage therapy research in aquaculture, its efficiency as an antimicrobial strategy and the critical aspects to successfully apply this therapy to control Aeromonas infection in fish.

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Section: Introductionmentioning

confidence: 99%

Bacteriophages in the Control of Aeromonas sp. in Aquaculture Systems: An Integrative View

et al. 2022

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“…India, for example, has conducted substantial research on different types of vaccines, including inactivated vaccines, live attenuated vaccines, and biofilm vaccines, all of which are based on various components of A. hydrophila. Previously, extracellular protein, S-layer protein, lipopolysaccharide, and Omp were identified as viable candidates [89]. Although local researchers in Malaysia are not interested in developing a vaccine against A. hydrophila, this is likely due to its complicated serotype and variable in virulence gene expression [70,90]; many efforts have been conducted in recent years and are summarized in Table-4.…”

Section: Motile Aeromonas Septicemia (Mas) Vaccinementioning

confidence: 99%

Current status and advances of fish vaccines in Malaysia

Ridzuan

Abdullah²,

Ramly³

et al. 2022

Vet World

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Fish diseases have a significant negative influence on the Malaysian aquaculture industry. Since the 1980s, the sector has grown in size, which has resulted in a rise in the prevalence of infectious outbreaks affecting both freshwater and marine cultured fish species. Demand for commercially available fish vaccinations is predicted to increase as infectious disease outbreaks continue to occur. In Malaysia, aquaculture vaccine research and development (R&D) are still in its infancy, with most efforts concentrating on producing vaccines against bacterial infections, most notably streptococcosis, vibriosis, and motile Aeromonas septicemia. Despite several attempts, no homegrown vaccine has been effectively introduced into the manufacturing pipeline to date. At the moment, only three imported aquatic vaccines have received full permission, a far cry from the 314 and 60 vaccines licensed in the poultry and porcine industries, respectively. This review will describe recent findings regarding the development of aquaculture vaccines for certain fish species and diseases in Malaysia. In our opinion, R&D on fish vaccines is critical to the aquaculture industry's viability.

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“…The major parasitecausing disease in fish in India is Ichthyophthirius mulifiliis (11) whose impact is not severe compared to bacterial pathogens. Overall, viral and parasitic diseases cause less economic losses unlike bacterial diseases that cause an adverse economic impact, calling for the urgent need of protective vaccines (17). The most prevalent bacterial pathogens in Indian aquaculture belong to the genera Aeromonas, Edwardsiella, Vibrio, and Flavobacterium, infecting the top farmed fish species (11,18).…”

Section: Major Bacterial Fish Pathogens In Indiamentioning

confidence: 99%

Application of Outer Membrane Protein-Based Vaccines Against Major Bacterial Fish Pathogens in India

et al. 2020

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Aquaculture is one of the fastest-growing food-producing sectors in the world. However, its growth is hampered by various disease problems due to infectious microorganisms, including Gram-negative bacteria in finfish aquaculture. Disease control in aquaculture by use of antibiotics is not recommended as it leads to antibiotic residues in the final product, selection, and spread of antibiotic resistance in the environment. Therefore, focus is on disease prevention by vaccination. All Gram-negative bacteria possess surface-associated outer membrane proteins (OMPs), some of which have long been recognized as potential vaccine candidates. OMPs are essential for maintaining the integrity and selective permeability of the bacterial membrane and play a key role in adaptive responses of bacteria such as solute and ion uptake, iron acquisition, antimicrobial resistance, serum resistance, and bile salt resistance and some adhesins have virulence attributes. Antigenic diversity among bacterial strains even within the same bacterial species has constrained vaccine developments, but OMPs that are conserved across serotypes could be used as potential candidates in vaccine development, and several studies have demonstrated their efficacy and potential as vaccine candidates. In this review, we will look into the application of OMPs for the design of vaccines based on recombinant proteins, subunit vaccines, chimeric proteins, and DNA vaccines as new-generation vaccine candidates for major bacterial pathogens of fish for sustainable aquaculture.

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Current prospects and challenges in fish vaccine development in India with special reference to Aeromonas hydrophila vaccine

Cited by 52 publications

References 89 publications

Bacteriophages in the Control of Aeromonas sp. in Aquaculture Systems: An Integrative View

Bacteriophages in the Control of Aeromonas sp. in Aquaculture Systems: An Integrative View

Current status and advances of fish vaccines in Malaysia

Application of Outer Membrane Protein-Based Vaccines Against Major Bacterial Fish Pathogens in India

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