Current progress in cancer immunotherapy based on natural killer cells

Bagheri, Yasin; Barati, Alireza; Aghebati‐Maleki, Ali; Yousefi, Mehdi

doi:10.1002/cbin.11465

Cited by 11 publications

(6 citation statements)

References 121 publications

(180 reference statements)

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“…First, the poor ability of NK cells to reach tumor tissues limits their application to the treatment of solid tumors (Melero et al, 2014 ). Second, the tumor microenvironments, including hypoxia, lack of nutrition, and nonappropriate metabolic conditions remain a major barrier to the effectiveness of transferring from NK cells to cancer cells (Bagheri et al, 2021 ). Acidic tumor microenvironments prevent Fas/FasL interactions and decrease perforin/granzyme B release from NK cells (Fischer et al, 2000 ).…”

Section: Discussionmentioning

confidence: 99%

Delivery of human natural killer cell-derived exosomes for liver cancer therapy: an in vivo study in subcutaneous and orthotopic animal models

Kim¹,

Min²,

Song³

et al. 2022

Drug Delivery

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Exosomes are nanosized extracellular vesicles secreted by various cell types, including those of the immune system, such as natural killer (NK) cells. They play a role in intercellular communication by transporting signal molecules between the cells. Recent studies have reported that NK cell-derived exosomes (NK-exo) contain cytotoxic proteins-induced cell death. However, the characteristics and potential functions of NK-exo, especially for the liver cancer are poorly understood. In this study, we investigated the anti-tumor effects of NK-exo in the primary liver cancer, hepatocellular carcinoma (HCC), using the orthotopic and subcutaneous tumor model. We found that NK-exo expressed both typical exosomal markers (e.g. CD63, CD81, and Alix) and cytotoxic proteins (e.g. perforin, granzyme B, FasL, and TRAIL). NK-exo were selectively taken up by HCC cells (e.g. Hep3B, HepG2, and Huh 7). Interestingly, Hep3B cells induced the highest cytotoxicity compared with HepG2 and Huh7 cells, and substantially enhanced the apoptosis by NK-exo. Furthermore, we demonstrated that NK-exo inhibited the phosphorylation of serine/threonine protein kinases (e.g. AKT and ERK1/2), and enhanced the activation of specific apoptosis markers (e.g. caspase-3, -7, -8, -9, and PARP) in Hep3B cells. NK-exo also exhibit the active targeting ability and potent therapeutic effects in both orthotopic and subcutaneous HCC mouse models. Overall, these results suggest that NK-exo indicate strong anti-tumor effects in HCC, which are mediated by novel regulatory mechanisms involved in serine/threonine kinase pathway-associated cell proliferation and caspase activation pathway-associated apoptosis.

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Section: Discussionmentioning

confidence: 99%

Delivery of human natural killer cell-derived exosomes for liver cancer therapy: an in vivo study in subcutaneous and orthotopic animal models

Kim¹,

Min²,

Song³

et al. 2022

Drug Delivery

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“…Notably, Laurent Boissel et al observed that CAR-NK cells exhibited enhanced elimination of primary chronic lymphocytic leukemia (CLL) cells through antibodydependent cell-mediated cytotoxicity (ADCC) mediated by anti-CD20 monoclonal antibodies [71]. iPSC-NK cells engineered with CARs offer several advantages: (1) they have fewer complications such as cytokine release syndrome (CRS), neurotoxicity, or GVHD; (2) they are not restricted by HLA; and (3) they can activate cytotoxic effects independently of the CAR itself [72][73][74][75][76][77]. In a study by Dan Kaufman's group, a first-generation CAR incorporating CD4/CD3ζ was introduced into iPSC-NK cells, demonstrating their ability to suppress human immunodeficiency virus (HIV) replication in CD4 + T cells [68].…”

Section: Translationmentioning

confidence: 99%

Immune Cell Generation from Human-Induced Pluripotent Stem Cells: Current Status and Challenges

Xiong,

Zheng

2024

Advances in Pluripotent Stem Cells

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The immune system plays a crucial role in recognizing and eliminating foreign antigens, working in conjunction with other bodily systems to maintain the stability and physiological balance of the internal environment. Cell-based immunotherapy has revolutionized the treatment of various diseases, including cancers and infections. However, utilizing autologous immune cells for such therapies is costly, time-consuming, and heavily reliant on the availability and quality of immune cells, which are limited in patients. Induced pluripotent stem cell (iPSC)-derived immune cells, such as T cells, natural killer (NK) cells, macrophages, and dendritic cells (DCs), offer promising opportunities in disease modeling, cancer therapy, and regenerative medicine. This chapter provides an overview of different culture methods for generating iPSC-derived T cells, NK cells, macrophages, and DCs, highlighting their applications in cell therapies. Furthermore, we discuss the existing challenges and future prospects in this field, envisioning the potential applications of iPSC-based immune therapy.

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“…NK cells are large granular lymphocytes of innate immunity, which do not require thymus for maturation. They play important role in defending the body against viruses naturally, as they do not require any prior exposure (immunologic memory) to that particular viral antigen, hence named “natural” killer cells ( Bagheri et al, 2021 ).…”

Section: General Applicationsmentioning

confidence: 99%

Emerging applications of nanotechnology in context to immunology: A comprehensive review

Mobeen

Safdar

Fatima

et al. 2022

Front. Bioeng. Biotechnol.

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Numerous benefits of nanotechnology are available in many scientific domains. In this sense, nanoparticles serve as the fundamental foundation of nanotechnology. Recent developments in nanotechnology have demonstrated that nanoparticles have enormous promise for use in almost every field of life sciences. Nanoscience and nanotechnology use the distinctive characteristics of tiny nanoparticles (NPs) for various purposes in electronics, fabrics, cosmetics, biopharmaceutical industries, and medicines. The exclusive physical, chemical, and biological characteristics of nanoparticles prompt different immune responses in the body. Nanoparticles are believed to have strong potential for the development of advanced adjuvants, cytokines, vaccines, drugs, immunotherapies, and theranostic applications for the treatment of targeted bacterial, fungal, viral, and allergic diseases and removal of the tumor with minimal toxicity as compared to macro and microstructures. This review highlights the medical and non-medical applications with a detailed discussion on enhanced and targeted natural and acquired immunity against pathogens provoked by nanoparticles. The immunological aspects of the nanotechnology field are beyond the scope of this Review. However, we provide updated data that will explore novel theragnostic immunological applications of nanotechnology for better and immediate treatment.

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Current progress in cancer immunotherapy based on natural killer cells

Cited by 11 publications

References 121 publications

Delivery of human natural killer cell-derived exosomes for liver cancer therapy: an in vivo study in subcutaneous and orthotopic animal models

Delivery of human natural killer cell-derived exosomes for liver cancer therapy: an in vivo study in subcutaneous and orthotopic animal models

Immune Cell Generation from Human-Induced Pluripotent Stem Cells: Current Status and Challenges

Emerging applications of nanotechnology in context to immunology: A comprehensive review

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