Current practice in the diagnosis and management of IBD-associated anaemia and iron deficiency in Germany: The German AnaemIBD Study

Blumenstein, Irina; Dignaß, Axel; Vollmer, S; Klemm, W; Weber-Mangal, S; Stein, J.

doi:10.1016/j.crohns.2014.03.010

Cited by 45 publications

(34 citation statements)

References 26 publications

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“…These findings are in agreement with other recent reports on the management of IBD patients diagnosed with anemia. A recent study from 55 German gastroenterological centers showed that only 43.5% of anemic IBD patients were treated for anemia (28). In another study from 9 European countries the majority of IBD patients with anemia were treated with oral iron (67%) whereas only 28% received IV iron (29).…”

Section: Discussionmentioning

confidence: 99%

Five-Year Period Prevalence and Characteristics of Anemia in a Large US Inflammatory Bowel Disease Cohort

Koutroubakis

Ramos-Rivers

Regueiro

et al. 2016

Journal of Clinical Gastroenterology

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Background Anemia is a common manifestation of inflammatory bowel disease (IBD) but its prevalence in the U.S. is not well defined. Aim of this study was to determine the prevalence and characteristics of anemia in IBD patients who were followed in a U.S. referral center. Methods Demographic, clinical, laboratory and treatment data from a prospective, consented longitudinal IBD registry between the years 2009-2013 were analyzed. Disease activity was evaluated using Harvey-Bradshaw index (HBI) in Crohn’s disease (CD) and ulcerative colitis (UC) activity index (UCAI) in UC as well as C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR). Anemia was defined based on the World Health Organization criteria. Results A total of 1821 IBD patients [1077 with CD, 744 with UC, median age 43.8 years, 51.9% female] were included. The 5-year period prevalence of anemia in IBD patients was 50.1%, (CD: 53.3% vs UC: 44.7%, P =0.001). In multivariate logistic regression analysis anemia was associated with surgery for IBD [odds ratio (OR) 2.77 95% confidence inderval (CI) (2.21-3.48) P<0.0001)], female gender (OR 1.29 95% CI 1.04-1.61 P=0.02), CRP (OR 1.26 95%CI 1.16-1.37 P<0.0001), ESR (OR 1.02 95%CI 1.01-1.03 P=0.0002) and use of biologics (OR 2.00 95%CI 1.58-2.52 P=0.0001) or immunomodulators (OR 1.51 95%CI 1.21-1.87 P=0.0003). Iron replacement therapy was administered to 46.8% of the anemic patients. Conclusions Anemia has a high period prevalence in IBD patients followed at a tertiary center. Anemia is more common in CD than in UC, is associated with disease activity and in current practice is undertreated.

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Section: Discussionmentioning

confidence: 99%

Five-Year Period Prevalence and Characteristics of Anemia in a Large US Inflammatory Bowel Disease Cohort

Koutroubakis

Ramos-Rivers

Regueiro

et al. 2016

Journal of Clinical Gastroenterology

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“…For example, Blumenstein et al revealed that in Germany 56.5% of IBD patients with anemia had not received adequate treatment [19]. Likewise, a web-based questionnaire of IBD patients showed that one third of those with anemia had not been treated accordingly [15].…”

Section: Introductionmentioning

confidence: 99%

Diagnosis and treatment of anemia in patients with inflammatory bowel disease

Mücke

Raine

et al. 2016

aog

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Anemia represents one of the most frequent complications in inflammatory bowel disease (IBD) and severely impairs the quality of life of affected patients. The etiology of anemia in IBD patients can be multifactorial, often involving a combination of iron deficiency (ID) and anemia of chronic disease (ACD). Although current guidelines recommend screening for and treatment of anemia in IBD patients, current observational data suggest that it still remains underdiagnosed and undertreated. Besides basic laboratory parameters (e.g. mean corpuscular volume, reticulocyte count, serum ferritin, transferrin saturation, etc.), the concentration of soluble transferrin receptor (sTfR) and novel parameters such as the sTfR/log ferritin index can guide the challenging task of differentiating between ID and ACD. Once identified, causes of anemia should be treated accordingly. This review summarizes our current understanding of anemia in IBD patients, including the underlying pathology, diagnostic approaches and appropriate anemia treatment regimens.

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“…Unfortunately, clinicians usually underestimate anemia in IBD patients 13 . A German survey among gastroenterologists found that more than 50% of patients with IBD-associated anemia were not treated, or were undertreated.…”

Section: Accepted Manuscriptmentioning

confidence: 99%